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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
53179-11-6
IUPAC name
N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide
State
State

At room temperature, Loperamide is typically in the form of a solid powder.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
505.30
Boiling point (Kelvin)
778.50
General information
Molecular weight
477.03g/mol
Molar mass
477.3480g/mol
Density
1.4100g/cm3
Appearence

Loperamide is typically found as a white to off-white powder. It is almost insoluble in water, but freely soluble in chloroform, methanol, and glacial acetic acid.

Comment on solubility

Solubility of N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide

The solubility of N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide can be influenced by a variety of factors, including its molecular structure, solvent polarity, and temperature conditions. Understanding the solubility characteristics of this compound is essential for applications in various scientific fields. Here are some important points to consider:

  • Polarity: The presence of the dimethylamino group can impart basic properties that may enhance solubility in polar solvents, while the phenyl groups contribute to hydrophobic interactions.

  • Solvent Compatibility: This compound may show better solubility in organic solvents such as ethanol or dichloromethane compared to water, indicating a preference for non-polar environments.

  • Temperature Effects: Increasing the temperature may help increase solubility in certain solvents, making it easier to dissolve the compound for various applications.

  • pH Influence: The basic nature of the dimethylamino group allows for potential protonation under acidic conditions, affecting solubility in a pH-dependent manner.

In summary, the solubility of N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide is influenced by its complex molecular interactions, making it imperative to choose the right solvent and conditions for optimal dissolution. As the saying goes, "Like dissolves like," which holds true for designing experiments with this fascinating compound.

Interesting facts

Interesting Facts about N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide

N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide is a compound often explored in the realm of medicinal chemistry. Here are some intriguing details about this compound:

  • Potential Therapeutic Applications: This compound is studied for potential roles in pharmacology, particularly as a candidate for developing new therapeutic agents. Its unique structure suggests that it may exhibit interesting biological activities.
  • Synthetic Pathways: The synthesis of this compound involves multiple steps, which include amide formation and the introduction of a dimethylamino group. These synthetic strategies are crucial in designing compounds with desired biological activities.
  • Structure-Activity Relationship (SAR): The structural features, such as the dimethylamino group and the phenyl rings, play significant roles in modulating the biological properties of the compound. Evaluating how modifications may affect activity is a key area of research.
  • Research Significance: Compounds of this type are often studied in various biological assays to determine their efficacy and safety profile. The exploration of their mechanisms of action can lead to discovering novel treatments for various conditions.
  • Multifunctionality: The ability of this compound to interact with different biological targets makes it an exciting subject for further research in drug development.

In conclusion, N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide embodies the complexity and potential of organic compounds in medicinal chemistry. The exploration of its properties and applications could pave the way for innovative advancements in therapeutic strategies.