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Loperamide hydrochloride

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Identification
Molecular formula
C29H34ClN2O2
CAS number
34552-83-5
IUPAC name
N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide;hydrochloride
State
State

Loperamide hydrochloride is typically found in a solid state at room temperature. It is processed into tablet or capsule form for medicinal use and is stable under standard conditions.

Melting point (Celsius)
223.20
Melting point (Kelvin)
496.40
Boiling point (Celsius)
355.46
Boiling point (Kelvin)
628.61
General information
Molecular weight
513.51g/mol
Molar mass
513.5050g/mol
Density
0.7202g/cm3
Appearence

Loperamide hydrochloride appears as a white to off-white crystalline powder. It is odorless and has a slightly bitter taste. The compound is often available in a solid powder form for manufacturing into tablets or capsules.

Comment on solubility

Solubility of N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide; hydrochloride

The solubility of N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide; hydrochloride is an important characteristic that influences its applications and efficacy. Being a hydrochloride salt, this compound typically exhibits enhanced solubility in polar solvents. Here are some key points regarding its solubility:

  • Polar Solvents: This compound is generally soluble in water and alcohols due to its ionic nature introduced by the hydrochloride form, making it favorable for formulations that require aqueous solubility.
  • Temperature Dependence: The solubility can be influenced by temperature, often increasing as the temperature rises, following the general principle of solubility.
  • pH Sensitivity: The solubility may vary with pH changes, particularly in biological systems. Thus, understanding the pH environment is crucial for optimal dissolution.

In summary, the solubility of this compound in aqueous environments makes it ideal for various applications, emphasizing the need for a keen understanding of its solubility characteristics in practical scenarios. As always, experimentation and specific context will provide the best insights into its behavior in solution.

Interesting facts

Interesting Facts about N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide; hydrochloride

N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide; hydrochloride is a fascinating compound, often drawing attention in various fields of chemistry and pharmacology. Here are some noteworthy aspects:

  • Pharmacological Relevance: This compound is of interest in the pharmaceutical industry due to its potential applications in drug formulation and development. Its unique structure allows for varied interactions with biological targets, contributing to its effectiveness.
  • Structure-Activity Relationship: The presence of the dimethylamino group significantly influences the compound's activity. This functional group enhances solubility and stability, making it a key feature in medicinal chemistry.
  • Synthetic Pathways: The synthesis of this compound can involve diverse organic reactions, providing students and researchers with various learning opportunities in synthetic methodology. Understanding these pathways can deepen knowledge of reaction mechanisms.
  • Potential Side Effects: As with many compounds that interact with biological systems, it is essential to consider potential side effects. Understanding these side effects is crucial for developing safe and effective pharmaceuticals.
  • Research Opportunities: The compound is a subject of ongoing research in fields such as neuropharmacology and cancer treatment, indicating its potential role in advancing medical science.

Overall, N-[3-(dimethylamino)-2-methyl-1-phenyl-propylidene]-2-phenyl-acetamide; hydrochloride highlights the intricate relationship between chemical structure and biological activity, making it an exciting area of study for chemists and pharmacologists alike.

Synonyms
N-(alpha-(1-(Dimethylamino)-1-methylethyl)benzilidene)-2-phenylacetamide monohydrochloride
16283-49-1
Acetamide, N-(alpha-(1-(dimethylamino)-1-methylethyl)benzilidene)-2-phenyl-, monohydrochloride