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Paracetamol

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Identification
Molecular formula
C8H9NO2
CAS number
103-90-2
IUPAC name
N-[3-[(dimethylamino)methyl]-4-hydroxy-phenyl]acetamide
State
State

At room temperature, paracetamol is in a solid state. It is generally stable and not prone to decomposition if stored properly.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
387.00
Boiling point (Kelvin)
660.15
General information
Molecular weight
151.16g/mol
Molar mass
151.1630g/mol
Density
1.2636g/cm3
Appearence

Paracetamol generally appears as a crystalline powder. It is either white or nearly white in color. The powder is slightly soluble in water and has no odor. It is typically prepared in various formulations for pharmaceutical purposes, such as tablets, capsules, syrups, and suppositories.

Comment on solubility

Solubility of N-[3-[(dimethylamino)methyl]-4-hydroxy-phenyl]acetamide

N-[3-[(dimethylamino)methyl]-4-hydroxy-phenyl]acetamide, a compound featuring both aromatic and amine functionalities, exhibits interesting solubility properties that can be influenced by various factors. Here are some key points to note:

  • Polarity: Due to the presence of the hydroxyl group and the dimethylamino group, this compound is expected to demonstrate significant polarity, which may enhance its solubility in polar solvents such as water and alcohols.
  • Hydrogen Bonding: The hydroxyl group allows the formation of hydrogen bonds, thus improving solubility in aprotic solvents and potentially facilitating interactions with biological systems.
  • Solubility in Organic Solvents: Depending on the specific interactions, the compound may also dissolve in less polar organic solvents, although the degree of solubility will vary.
  • pH Dependence: The solubility might be influenced by the pH of the solution since the protonation state of the amine can alter solubility characteristics.

In summary, while N-[3-[(dimethylamino)methyl]-4-hydroxy-phenyl]acetamide is expected to be soluble in various polar solvents due to its functional groups, the exact solubility behavior will depend on factors such as temperature, pH, and the choice of solvent. This multifaceted nature of solubility makes the compound a subject of interest in chemical and pharmaceutical applications.

Interesting facts

Interesting Facts about N-[3-[(dimethylamino)methyl]-4-hydroxy-phenyl]acetamide

N-[3-[(dimethylamino)methyl]-4-hydroxy-phenyl]acetamide is a fascinating compound with numerous applications and characteristics that make it stand out in the field of chemistry. Below are some interesting insights:

  • Pharmaceutical Applications: This compound is notably explored for its potential use in the pharmaceutical industry, particularly as an intermediate in the synthesis of various therapeutic agents.
  • Dimethylamino Group: The presence of the dimethylamino group is key to enhancing the compound's solubility and biological activity, making it a valuable structure in medicinal chemistry.
  • Hydroxyl Functionality: The 4-hydroxy group contributes significantly to the compound's properties, enabling interactions through hydrogen bonding, which can enhance bioavailability.
  • Structure-Activity Relationship (SAR): Understanding the specific arrangement and functional groups in compounds like this one can lead to insights into their biological functions and aid in drug development processes.
  • Colorimetric Studies: The compound can be involved in colorimetric analytical methods, helping scientists in quantifying related substances in a mixture by leveraging its chemical reactivity.

As with many compounds in the realm of organic chemistry, the study of N-[3-[(dimethylamino)methyl]-4-hydroxy-phenyl]acetamide opens doors to understanding complex reactions and enhancing the efficiency of drug design processes. It is a remarkable example of how small changes in molecular structure can lead to significant differences in functionality.

Synonyms
13886-04-9
m-ACETOTOLUIDIDE, alpha-(DIMETHYLAMINO)-4'-HYDROXY-
N-[3-[(Dimethylamino)methyl]-4-hydroxyphenyl]acetamide
NSC 85488
alpha-(Dimethylamino)-4'-hydroxy-m-acetotoluidide
4MW4Y482KM
NSC-85488
N-(3-((dimethylamino)methyl)-4-hydroxyphenyl)acetamide
BRN 2808683
NSC85488
3-(Dimethylaminomethyl)-4-hydroxy acetanilide
NCIOpen2_004897
UNII-4MW4Y482KM
orb1985727
m-Acetotoluidide, .alpha.-(dimethylamino)-4'-hydroxy-
SCHEMBL28837437
DTXSID50160820
WLN: 1VMR DQ C1N1&1
AKOS022649485
.alpha.-(Dimethylamino)-4'-hydroxy-m-acetotoluidide
N-(3-Dimethylaminomethyl-4-hydroxy-phenyl)-acetamide
ACETAMIDE, N-(3-((DIMETHYLAMINO)METHYL)-4-HYDROXYPHENYL)-