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N-(3-ethoxyphenyl)-2-iodoacetamide

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Identification
Molecular formula
C10H12I-NO2
CAS number
17572-82-2
IUPAC name
N-(3-ethoxyphenyl)-2-iodo-acetamide
State
State

At room temperature, N-(3-ethoxyphenyl)-2-iodoacetamide is in a solid state, typically taking the form of a powder. It remains stable under standard conditions of storage and handling.

Melting point (Celsius)
113.00
Melting point (Kelvin)
386.00
Boiling point (Celsius)
270.00
Boiling point (Kelvin)
543.00
General information
Molecular weight
291.06g/mol
Molar mass
291.0640g/mol
Density
2.0500g/cm3
Appearence

This compound typically appears as a crystalline solid, usually in the form of a powder. The color may vary slightly but is generally white or off-white, indicating a high level of purity when freshly prepared.

Comment on solubility

Solubility of N-(3-ethoxyphenyl)-2-iodo-acetamide

The solubility of N-(3-ethoxyphenyl)-2-iodo-acetamide presents an interesting profile due to its unique chemical structure. This compound, characterized by the presence of the ethoxy group and an iodo moiety, often exhibits moderate to good solubility in various organic solvents.

Key Considerations for Solubility:

  • Polarity: The presence of the ethoxy group can enhance solubility in polar solvents, while the iodo substituent gives it some lipophilic character.
  • Solvent Type: It typically dissolves well in solvents such as ethanol, methanol, and DMSO, which are capable of interacting with its polar parts.
  • Hydrogen Bonding: The acetamide functionality can participate in hydrogen bonding, potentially increasing solubility in protic solvents.
  • Temperature Effects: Increasing the temperature often enhances the solubility of organic compounds, including N-(3-ethoxyphenyl)-2-iodo-acetamide.

As with many organic compounds, the solubility can vary significantly based on specific conditions. Understanding these solubility characteristics is crucial for applications in synthesis and formulations, where solubility can impact reactivity and bioavailability. In conclusion, *it is essential to consider both the chemical structure and interaction with solvents to fully comprehend the solubility behavior of this compound.*

Interesting facts

Interesting Facts about N-(3-ethoxyphenyl)-2-iodo-acetamide

N-(3-ethoxyphenyl)-2-iodo-acetamide is a fascinating organic compound that's notable not just for its structural complexity but also for its potential applications in the field of medicinal chemistry. Here are some intriguing insights about this compound:

  • Structural Features: The compound features an acetamide group, which is a hallmark of many pharmacologically active substances. The presence of an iodine atom introduces unique reactivity ways in organic synthesis.
  • Biological Activity: Compounds similar to N-(3-ethoxyphenyl)-2-iodo-acetamide have been explored for their potential antimicrobial and anticancer properties. In drug design, iodine can enhance biological activity while also serving as a useful label in imaging studies.
  • Applications in Synthesis: Iodinated compounds are often employed in the synthesis of more complex molecules due to their versatility in electrophilic substitution reactions. This makes N-(3-ethoxyphenyl)-2-iodo-acetamide a valuable precursor in the exploration of novel therapeutics.
  • Interactions with Biological Macromolecules: The aromatic part of the structure may enable interactions with proteins and nucleic acids, which is critical in the development of compounds aimed at modulating biological pathways.
  • Research Implications: Studying such compounds can give insights into structure-activity relationships (SAR) that are crucial for the optimization of drug candidates.

In summary, N-(3-ethoxyphenyl)-2-iodo-acetamide represents a compelling intersection of chemistry and pharmacology. As research progresses, it may play a key role in the development of new therapeutic agents, showcasing the endless possibilities that organic chemistry holds.

Synonyms
17641-14-4
m-ACETOPHENETIDIDE, 2-IODO-
2-Iodo-m-acetophenetidide
m-Phenetidine, N-(iodoacetyl)-
N-(Iodoacetyl)-m-phenetidide
BRN 2722294
DTXSID80170134
DTXCID4092625
N-(3-ethoxyphenyl)-2-iodoacetamide
orb1985735
AKOS040752900