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N'-(3-fluorophenyl)pyridine-4-carboxamidine

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Identification
Molecular formula
C12H10FN3
CAS number
486460-32-6
IUPAC name
N'-(3-fluorophenyl)pyridine-4-carboxamidine
State
State

This compound is a solid at room temperature.

Melting point (Celsius)
136.00
Melting point (Kelvin)
409.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
273.15
General information
Molecular weight
202.22g/mol
Molar mass
202.2200g/mol
Density
1.3000g/cm3
Appearence

The compound appears as a crystalline solid. It is typically white to slightly off-white in color.

Comment on solubility

Solubility of N'-(3-fluorophenyl)pyridine-4-carboxamidine

N'-(3-fluorophenyl)pyridine-4-carboxamidine possesses unique solubility characteristics owing to its molecular structure. The compound is expected to exhibit variable solubility in different solvents:

  • Apolar solvents: Due to its aromatic nature, it may have limited solubility in nonpolar solvents.
  • Polar solvents: It likely shows better solubility in polar protic solvents such as water and alcohols, as the presence of carboxamidine functional groups can facilitate hydrogen bonding.
  • Organic solvents: The compound may be moderately soluble in organic solvents like dimethyl sulfoxide (DMSO) and methanol due to interactions with solvent molecules.

Furthermore, the fluorine atom in the structure can influence solubility by increasing polarity, which may enhance interactions with polar solvents. It is also important to note that the degree of solubility can be influenced by temperature, pH, and the presence of other ions in solution.

In summary, the solubility of N'-(3-fluorophenyl)pyridine-4-carboxamidine can be classified as:

  1. Limited in apolar solvents
  2. Moderate to good in polar solvents
  3. Variable in organic solvents, depending on the specific conditions

Understanding the solubility profile of this compound is crucial for its applications in various chemical processes and formulations.

Interesting facts

Exploring N'-(3-Fluorophenyl)pyridine-4-carboxamidine

N'-(3-fluorophenyl)pyridine-4-carboxamidine is a fascinating compound that falls into a category often associated with substantial pharmacological potential. This compound showcases a unique structure that can open doors to various applications in drug development and material science. Here are some compelling aspects of this compound:

  • Pharmacological Potential: Compounds like N'-(3-fluorophenyl)pyridine-4-carboxamidine are often investigated for their role in medicinal chemistry, particularly due to their ability to interact with biological targets. These interactions can lead to the development of new therapeutic agents.
  • Fluorine's Role: The presence of fluorine in the molecule can significantly enhance its biological activity and metabolic stability. Fluorine atoms can modify the lipophilicity of the compound, which affects how the compound is absorbed and distributed in the body.
  • Pyridine Moiety: The pyridine ring is a well-known structure in organic chemistry and is frequently found in numerous natural products and synthetic drugs. It contributes to the overall basicity and reactivity of the compound, making it a valuable building block in many chemical synthesis pathways.
  • Carboxamidine Group: The carboxamidine functional group adds another layer of complexity to the molecule, often providing sites for hydrogen bonding and coordination with biological macromolecules, further contributing to its pharmacological profile.

This compound highlights the intricate relationship between molecular structure and biological activity, making it a subject of interest not only in academia but also in pharmaceutical industries. As researchers continue to explore the potential of compounds like N'-(3-fluorophenyl)pyridine-4-carboxamidine, we may uncover new therapies that can address unmet medical needs.

In summary, N'-(3-fluorophenyl)pyridine-4-carboxamidine exemplifies the complexity of synthetic chemistry and pharmacology, reminding us of the great potential that lies within meticulously designed chemical entities.

Synonyms
N-(m-Fluorophenyl)isonicotinamidine
23565-11-9
ISONICOTINAMIDINE, N-(m-FLUOROPHENYL)-
BRN 0476114
4-Pyridinecarboximidamide, N-(3-fluorophenyl)-
DTXSID50178187
RefChem:349658
DTXCID80100678