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N-(3-hydroxyphenyl)butanamide

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Identification
Molecular formula
C10H13NO2
CAS number
NA
IUPAC name
N-(3-hydroxyphenyl)butanamide
State
State

This compound is typically a solid at room temperature.

Melting point (Celsius)
109.00
Melting point (Kelvin)
382.15
Boiling point (Celsius)
333.10
Boiling point (Kelvin)
606.25
General information
Molecular weight
179.22g/mol
Molar mass
179.2160g/mol
Density
1.1792g/cm3
Appearence

N-(3-hydroxyphenyl)butanamide usually appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of N-(3-hydroxyphenyl)butanamide

N-(3-hydroxyphenyl)butanamide, with its unique structure, presents interesting solubility characteristics. When considering its solubility, several key factors come into play:

  • Polarity: The presence of the hydroxyl group (-OH) on the phenyl ring contributes significantly to the polarity of the molecule, allowing for hydrogen bonding with water.
  • Hydrophilic vs Hydrophobic Balance: The butanamide side chain provides some hydrophobic character, but overall, the compound tends to be more hydrophilic due to the hydroxyl group.
  • Solvent Interaction: N-(3-hydroxyphenyl)butanamide is likely to be soluble in polar solvents such as water and ethanol, while its solubility in non-polar solvents may be limited.

In summary, it can be anticipated that N-(3-hydroxyphenyl)butanamide exhibits moderate to high solubility in aqueous environments. This behavior is primarily due to the balance of its functional groups, which facilitate interactions with polar solvents. As the solubility greatly influences the compound's bioavailability and applications, understanding these characteristics is crucial for its practical uses.

Interesting facts

Interesting Facts about N-(3-hydroxyphenyl)butanamide

N-(3-hydroxyphenyl)butanamide, also known as a derivative of butanoic acid, is a fascinating compound noteworthy for several reasons:

  • Biological Relevance: This compound is significant in biochemistry, particularly in the study of metabolic pathways. It has potential derivatives that may exhibit biological activity or therapeutic effects.
  • Chemical Structure: The presence of the 3-hydroxyphenyl group introduces unique steric and electronic properties that can influence its reactivity and interactions with other molecules.
  • Applications: Compounds related to N-(3-hydroxyphenyl)butanamide may find applications in pharmaceuticals. Their hydroxyl group could contribute to hydrogen bonding, impacting solubility and bioavailability.
  • Synthesis: The synthesis of this compound typically involves simple yet efficient organic reactions. Understanding these methods provides insight into synthetic organic chemistry practices.
  • Research Potential: Many derivatives of amides are currently a subject of extensive research for their potential in drug development. The study of this compound could align with pharmaceutical advancements.

In the words of a prominent chemist, “Chemistry is the link between science and life.” This compound exemplifies that connection, showcasing its relevance in both laboratory settings and potential real-world applications.


In summary, N-(3-hydroxyphenyl)butanamide is more than just a chemical entity; it represents a bridge to understanding complex biological processes, effective synthesis methodologies, and future applications in medicine.

Synonyms
21556-79-6
3'-Hydroxybutyranilide
BUTYRANILIDE, 3'-HYDROXY-
BRN 2209688
Butanamide, N-(3-hydroxyphenyl)-
DTXSID30175891
3-13-00-00952 (Beilstein Handbook Reference)
RefChem:331216
DTXCID6098382
N-(3-hydroxyphenyl)butanamide
N-(3-Hydroxyphenyl)butyramide
MFCD00460472
3-butyramidophenol
SCHEMBL2885788
SCHEMBL5541810
FMRBYRAQTPTELH-UHFFFAOYSA-N
AKOS002944355
BS-37579
DB-188384
CS-0449928
F309916