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Methaqualone

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Identification
Molecular formula
C16H14ClN3O
CAS number
72-44-6
IUPAC name
N-(3-methoxyphenyl)-N-methyl-nitrous amide
State
State

At room temperature, methaqualone is a solid that is primarily utilized in its tablet form in various pharmaceutical applications.

Melting point (Celsius)
113.00
Melting point (Kelvin)
386.20
Boiling point (Celsius)
238.50
Boiling point (Kelvin)
511.60
General information
Molecular weight
250.30g/mol
Molar mass
250.2970g/mol
Density
1.0750g/cm3
Appearence

Methaqualone is a pale yellow solid in its pure form. It is typically found in powdered form or as tablets for pharmaceutical use. The texture can range from crystalline to hard-pressed tablets.

Comment on solubility

Solubility of N-(3-methoxyphenyl)-N-methyl-nitrous amide

N-(3-methoxyphenyl)-N-methyl-nitrous amide, a compound with a unique structure, displays interesting solubility characteristics that merit attention. Understanding the solubility of this compound can provide insights into its potential applications and interactions in various solvents.

General Solubility Behavior

This compound may exhibit the following solubility characteristics:

  • Aromatic Properties: Due to the presence of the aromatic — specifically the 3-methoxyphenyl group — N-(3-methoxyphenyl)-N-methyl-nitrous amide may be more soluble in organic solvents.
  • Polar vs Non-Polar Solvents: It is likely to dissolve well in polar aprotic solvents such as dimethyl sulfoxide (DMSO) or acetonitrile, but may have limited solubility in non-polar solvents like hexane.
  • Temperature Influence: The solubility can vary significantly with temperature, where higher temperatures tend to increase solubility in most solvents.

Factors Influencing Solubility

Several factors can influence the solubility of N-(3-methoxyphenyl)-N-methyl-nitrous amide:

  • Hydrogen Bonding: The presence of functional groups capable of hydrogen bonding can enhance solubility in polar solvents.
  • Molecular Weight: Higher molecular weight may generally lead to lower solubility in solvents.
  • pH Level: The ionization state of the compound, influenced by the surrounding pH, can also play a crucial role in its solubility.

In summary, while N-(3-methoxyphenyl)-N-methyl-nitrous amide's solubility may depend heavily on the specific solvent and conditions, it remains a compound of interest in various chemical applications. Understanding its solubility behavior is key to leveraging its full potential.

Interesting facts

Interesting Facts About N-(3-Methoxyphenyl)-N-methyl-nitrous Amide

N-(3-Methoxyphenyl)-N-methyl-nitrous amide, often referred to in the scientific community for its unique properties, is a fascinating compound that is studied for various applications in chemistry and pharmacology. Here are some noteworthy facts:

  • Interesting Structure: The compound features a nitrous amide functional group, which is significant in the study of medicinal chemistry due to its potential reactivity in biological systems.
  • Potential Applications: Its unique structure may lead to interesting applications in drug design, particularly in the development of pharmaceuticals targeting specific biological pathways.
  • Research Implications: Compounds like N-(3-methoxyphenyl)-N-methyl-nitrous amide are often evaluated for their role in modulating enzyme activity or acting as intermediates in synthetic pathways.
  • Method of Synthesis: The synthesis often involves the manipulation of nitroso compounds, sparking interest in reactions that incorporate nitrogen functionality, which is a key theme in the development of various agrochemicals and pharmaceuticals.
  • Safety and Handling: As with many nitrous compounds, it’s critical to handle N-(3-methoxyphenyl)-N-methyl-nitrous amide with care, as it can exhibit varying levels of unpredictable reactivity depending on environmental conditions.

In summary, N-(3-methoxyphenyl)-N-methyl-nitrous amide is more than just a compound; it represents a touchstone in the exploration of nitrous chemistry and its implications in scientific research. As a result, this compound invites chemists and students alike to delve deeper into its potential and to explore new horizons in synthetic and medicinal chemistry.

Synonyms
m-ANISIDINE, N-METHYL-N-NITROSO-
N-Methyl-N-nitroso-m-anisidine
BRN 1841740
3-Methoxy-N-methyl-N-nitrosobenzenamine
Benzenamine, 3-methoxy-N-methyl-N-nitroso-
DTXSID50171794
4-16-00-00879 (Beilstein Handbook Reference)
DTXCID0094285
Benzenamine, 3-methoxy-N-methyl-N-nitroso-(9CI)
18559-18-7
(3-Methoxyphenyl)methylnitrosamine
N-(3-methoxyphenyl)-N-methylnitrous amide
SCHEMBL17001112
CCG-2062
SY375669