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N-(3-Trifluoromethylphenyl)acetamide

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Identification
Molecular formula
C9H8F3NO
CAS number
7462-48-8
IUPAC name
N-[3-(trifluoromethyl)phenyl]acetamide
State
State

At room temperature, N-(3-Trifluoromethylphenyl)acetamide is in a solid state. It can often be found as a crystalline substance.

Melting point (Celsius)
104.00
Melting point (Kelvin)
377.00
Boiling point (Celsius)
284.00
Boiling point (Kelvin)
557.00
General information
Molecular weight
201.18g/mol
Molar mass
201.1750g/mol
Density
1.3188g/cm3
Appearence

N-(3-Trifluoromethylphenyl)acetamide is typically a white to off-white crystalline solid. It may appear as a powder or granules, depending on the method of preparation and handling.

Comment on solubility

Solubility of N-[3-(trifluoromethyl)phenyl]acetamide

N-[3-(trifluoromethyl)phenyl]acetamide is an intriguing compound when considering its solubility characteristics. The presence of the trifluoromethyl group contributes to the compound's unique properties. Here are some key points regarding its solubility:

  • Polarity: The trifluoromethyl substituent makes the phenyl ring more electronegative, potentially influencing the overall polarity of the compound.
  • Solvent Compatibility: N-[3-(trifluoromethyl)phenyl]acetamide may exhibit different solubility patterns in various solvents, often being more soluble in polar organic solvents like dimethyl sulfoxide (DMSO) and tetrahydrofuran (THF).
  • Temperature Dependence: As with many organic compounds, solubility can exhibit significant temperature dependence; increasing temperature may enhance solubility in certain solvents.
  • Hydrogen Bonding: The amide functional group in the compound allows for hydrogen bonding, which can increase solubility in protic solvents.

In summary, the solubility of N-[3-(trifluoromethyl)phenyl]acetamide is influenced by its molecular structure, functional groups, and the nature of the solvent. This complex interaction of factors means that it may not be easily categorized, making it essential for researchers to conduct specific solubility tests for precise applications. As the adage goes, “like dissolves like,” and understanding these nuances can lead to more effective use of this compound in various chemical contexts.

Interesting facts

Interesting Facts about N-[3-(trifluoromethyl)phenyl]acetamide

N-[3-(trifluoromethyl)phenyl]acetamide is a fascinating compound that has garnered interest in various fields such as pharmaceutical chemistry and material science. Here are some key points that stand out about this intriguing compound:

  • Unique Functional Group: The presence of the trifluoromethyl group is particularly noteworthy. Known for its strong electron-withdrawing properties, this group enhances the compound's ability to participate in various chemical reactions.
  • Applications in Pharmaceuticals: Compounds containing acetamide and trifluoromethyl groups are often investigated for their biological activities. They may exhibit potential as drug candidates due to increased potency and selectivity.
  • Role in Medicinal Chemistry: Researchers are continually exploring N-[3-(trifluoromethyl)phenyl]acetamide for its interactions at the molecular level, which can lead to the development of innovative therapeutic agents.
  • Material Science Potential: Beyond the biological realm, this compound's unique properties may make it beneficial in developing advanced materials, such as coatings and polymers with improved chemical resistance.
  • Environmental Impact: Due to the trifluoromethyl group, there are discussions about the environmental implications of using this compound, particularly concerning its persistence and bioaccumulation. Thus, understanding its behavior in biological systems is crucial.

In conclusion, N-[3-(trifluoromethyl)phenyl]acetamide is more than just a chemical structure; it is a gateway to innovations in medicinal chemistry and material science. The ongoing research and exploration of its properties offer promising prospects for new technologies and therapeutic solutions.

Synonyms
351-36-0
N-(3-(Trifluoromethyl)phenyl)acetamide
3-(TRIFLUOROMETHYL)ACETANILIDE
3-Acetamidobenzotrifluoride
3'-(trifluoromethyl)acetanilide
m-Trifluoromethylacetanilide
N-[3-(Trifluoromethyl)phenyl]acetamide
3-Trifluoromethylacetanilide
USAF MA-14
3'-Trifluoromethylacetanilide
1-Acetamido-3-trifluoromethylbenzene
m-Trifluoromethyl acetanilide
Acetanilide, 3-(trifluoromethyl)-
alpha,alpha,alpha-Trifluoro-m-acetotoluidide
Acetamide, N-[3-(trifluoromethyl)phenyl]-
NSC 30581
EINECS 206-512-2
m-(Trifluoromethyl)acetanilide
BRN 2213222
N-(alpha,alpha,alpha-Trifluoro-m-tolyl)acetamide
AI3-13006
Acetamide, N-(3-(trifluoromethyl)phenyl)-
m-Acetotoluidide, alpha,alpha,alpha-trifluoro-
Acetamide, N-(3-(trifluoromethyl)phenyl)- (9CI)
DTXSID60188595
3-12-00-01989 (Beilstein Handbook Reference)
NSC-30581
NSC-60257
WLN: FXFFR CMV1
M-(trifluorome)acetanilide
m-Acetaminobenzotrifluoride
m-Acetotoluidide, .alpha.,.alpha.,.alpha.-trifluoro-
.alpha.,.alpha.-Trifluoro-m-acetotoluidide
m-Acetotoluidide,.alpha.,.alpha.-trifluoro-
N-(.alpha.,.alpha.-Trifluoro-m-tolyl)acetamide
NSC60257
MFCD00000383
Maybridge1_005905
N-(3-TRIFLUOROMETHYLPHENYL)ACETAMIDE
EU7ETU84SK
SCHEMBL505220
CHEMBL4070027
HMS558E09
DTXCID20111086
BSYSFLHKSDXURE-UHFFFAOYSA-N
NSC30581
AKOS003626056
FS-3859
N-(3-Trifluoromethyl-phenyl)-acetamide
SB77829
Acetamide, N-3-(trifluoromethyl)phenyl-
N-[3-(Trifluoromethyl)phenyl]acetamide #
DB-048735
CS-0187542
NS00042103
N-Acetyl-alpha,alpha,alpha-trifluoro-m-toluidine
Acetamide, N-(3-(trifluoromethyl)phenyl)-(9CI)
AE-641/02012023
SR-01000397478
.alpha.,.alpha.,.alpha.-Trifluoro-m-acetotoluidide
SR-01000397478-1
N-(.alpha.,.alpha.,.alpha.-Trifluoro-m-tolyl)acetamide
206-512-2