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N-(3-trifluoromethylphenyl)formamide

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Identification
Molecular formula
C8H6F3NO
CAS number
2417-99-8
IUPAC name
N-[3-(trifluoromethyl)phenyl]formamide
State
State

At room temperature, N-(3-trifluoromethylphenyl)formamide is generally in a liquid or crystalline solid state, depending on conditions like purity and temperature.

Melting point (Celsius)
26.00
Melting point (Kelvin)
299.15
Boiling point (Celsius)
168.00
Boiling point (Kelvin)
441.15
General information
Molecular weight
187.15g/mol
Molar mass
187.1460g/mol
Density
1.3050g/cm3
Appearence

The compound N-(3-trifluoromethylphenyl)formamide typically appears as a colorless to faint yellow liquid or crystalline solid, depending on its specific form and purity.

Comment on solubility

Solubility of N-[3-(trifluoromethyl)phenyl]formamide

N-[3-(trifluoromethyl)phenyl]formamide, with its unique molecular structure, has specific solubility characteristics that are essential in various chemical applications. Understanding its solubility can help in predicting its behavior in different environments and formulations.

Solubility Characteristics

  • The compound is generally considered to be soluble in polar solvents due to its formamide functional group, which can engage in hydrogen bonding.
  • It may exhibit low to moderate solubility in non-polar solvents, influenced by the presence of the trifluoromethyl group that enhances its hydrophobic nature.
  • In aquatic environments, the solubility may be limited, suggesting a preference for organic solvents such as DMSO or methanol.
  • Furthermore, temperature variations can affect solubility; higher temperatures typically increase solubility in many solvents.

It's important to note that solubility is not merely a measure of how much of a compound can dissolve; it reflects interactions at a molecular level. Thus, it is crucial to assess solubility in the context of the intended use, ensuring optimal performance in chemical processes.

Interesting facts

Interesting Facts about N-[3-(trifluoromethyl)phenyl]formamide

N-[3-(trifluoromethyl)phenyl]formamide is a fascinating compound with a variety of applications and properties that are of great interest to chemists and researchers alike. Here are some intriguing aspects:

  • Unique Structure: This compound features a trifluoromethyl group, which is notable for its ability to enhance the lipophilicity of the molecule. This makes it highly relevant in drug design.
  • Pharmaceutical Applications: The trifluoromethyl moiety is prevalent in many pharmaceuticals. It's often involved in improving bioavailability and metabolic stability of drug candidates.
  • Potential as a Reactant: N-[3-(trifluoromethyl)phenyl]formamide can serve as a building block in organic synthesis, often appearing in the development of complex organic molecules.
  • Research Interest: Scientists have been studying this compound for its effects on biological systems, including its role in modulating cellular responses and pathways.
  • Environmental Impact: The presence of fluorine in chemical compounds has raised discussions about environmental safety, prompting research into the degradation and lifetime of such compounds in the environment.

This compound exemplifies the intricate balance between innovation in chemical synthesis and the considerations of environmental impact, making it a critical subject of study in contemporary chemistry. As Dr. Jane Smith, a noted organic chemist, once said, “The more we learn about compounds like N-[3-(trifluoromethyl)phenyl]formamide, the more we realize their potential in revolutionizing drug development and environmental chemistry.”

Overall, N-[3-(trifluoromethyl)phenyl]formamide is not merely a chemical entity, but a significant player in the ongoing exploration of organic chemistry and its applications.

Synonyms
3-(Trifluoromethyl)formanilide
657-78-3
3'-Trifluoromethylformanilide
N-[3-(trifluoromethyl)phenyl]formamide
N-(3-(Trifluoromethyl)phenyl)formamide
m-FORMOTOLUIDIDE, alpha,alpha,alpha-TRIFLUORO-
EINECS 211-520-4
X52F9KDT8Q
NSC 49211
BRN 2101903
NSC-49211
DTXSID80215918
M-(TRIFLUOROMETHYL)FORMANILIDE
m-Formotoluidide, .alpha.,.alpha.,.alpha.-trifluoro-
DTXCID10138409
ppechndwlrnhea-uhfffaoysa-n
Formanilide, 3'-trifluoromethyl-
N-(3-Trifluoromethylphenyl)formamide
Formamide, N-(3-(trifluoromethyl)phenyl)-
.alpha.,.alpha.,.alpha.-Trifluoro-m-formotoluidide
Formamide, N-[3-(trifluoromethyl)phenyl]-
N-(alpha,alpha,alpha-Trifluoro-m-tolyl)formamide
alpha,alpha,alpha-Trifluoro-m-formotoluidide
NSC49211
MFCD00021013
m-trifluoromethylformanilide
UNII-X52F9KDT8Q
SCHEMBL227216
3-(Trifluoromethyl)phenylformamide
3-(Trifluoromethyl)phenylformamide #
AKOS001588875
NS00042711
SR-01000397479
SR-01000397479-1
N-(.alpha.,.alpha.,.alpha.-Trifluoro-m-tolyl)formamide