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Pyridine-4-carboximidamide, N'-[3-(trifluoromethyl)phenyl]-

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Identification
Molecular formula
C13H10F3N3
CAS number
715210-45-0
IUPAC name
N'-[3-(trifluoromethyl)phenyl]pyridine-4-carboxamidine
State
State

At room temperature, it is in a solid state.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
443.00
Boiling point (Kelvin)
716.15
General information
Molecular weight
223.20g/mol
Molar mass
223.2010g/mol
Density
1.3500g/cm3
Appearence

The compound appears as a crystalline solid, typically displaying a white to off-white color. Its crystalline structure is a result of the specific arrangement of the molecules within the crystal lattice.

Comment on solubility

Solubility of N'-[3-(trifluoromethyl)phenyl]pyridine-4-carboxamidine

N'-[3-(trifluoromethyl)phenyl]pyridine-4-carboxamidine, a compound with distinct structural features, presents interesting solubility characteristics that are often pivotal in its applications:

  • Polar Nature: The presence of the pyridine ring and carboxamidine group contributes to the compound's polar nature, suggesting potential solubility in polar solvents.
  • Solvent Compatibility: It may demonstrate adequate solubility in solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Methanol
    • Aqueous solutions (to a certain extent)
  • Limited Solubility: However, it may show limited solubility in non-polar solvents due to its fluorinated aromatic component, which can hinder dissolving in non-polar environments.
  • Temperature Effects: Solubility can also be affected by temperature, with higher temperatures generally enhancing solubility in most cases.

In summary, while N'-[3-(trifluoromethyl)phenyl]pyridine-4-carboxamidine is likely to be soluble in polar solvents, its solubility in non-polar media is expected to be significantly lower. The complex interplay of its functional groups and the presence of fluorine dictate these solubility behaviors, making understanding its solubility essential for both theoretical studies and practical applications.

Interesting facts

Interesting Facts about N'-[3-(trifluoromethyl)phenyl]pyridine-4-carboxamidine

N'-[3-(trifluoromethyl)phenyl]pyridine-4-carboxamidine is a fascinating compound that showcases the intricate interplay between organic chemistry and modern pharmaceuticals. This compound is particularly interesting due to its unique structural properties and potential applications.

Key Features

  • Functional Groups: The presence of both a pyridine and a carboxamidine group in this compound highlights its versatility. These functional groups can influence the compound's reactivity and its interactions in biological systems.
  • Trifluoromethyl Substitution: The trifluoromethyl group (-CF3) is known for its electron-withdrawing properties, which can enhance the lipophilicity of the compound, potentially improving its bioavailability in drug design.
  • Applications in Medicine: Compounds like N'-[3-(trifluoromethyl)phenyl]pyridine-4-carboxamidine are investigated for various medicinal applications, including their roles as potential inhibitors in enzymatic reactions or targets in cancer therapies.

Chemical Significance

This compound is a part of a class of compounds that are often studied for their effectiveness as drug candidates. The unique arrangement of atoms and the presence of electronegative fluorine atoms can lead to interesting electronic properties, which are crucial in the development of small-molecule therapeutics.

Quote from the Field

As one chemist noted, “The trifluoromethyl group can dramatically influence the pharmacodynamics of a compound, making it a powerful tool in the design of new drugs.” This encapsulates the importance of understanding the subtleties in chemical structures when developing new therapies.

Overall, N'-[3-(trifluoromethyl)phenyl]pyridine-4-carboxamidine embodies the fusion of traditional organic chemistry with cutting-edge drug development strategies, making it a significant subject of study for both chemists and pharmacologists alike.

Synonyms
23565-12-0
BRN 0484665
N-(alpha,alpha,alpha-Trifluoro-m-tolyl)isonicotinamidine
ISONICOTINAMIDINE, N-(alpha,alpha,alpha-TRIFLUORO-m-TOLYL)-
4-Pyridinecarboximidamide, N-(3-(trifluoromethyl)phenyl)-
DTXSID10178188
RefChem:349657
DTXCID40100679