Skip to main content

Leflunomide

ADVERTISEMENT
Identification
Molecular formula
C12H9Cl2NOS
CAS number
75706-12-6
IUPAC name
N-(3,4-dichlorophenyl)-1-ethylsulfanyl-methanimidothioic acid
State
State

At room temperature, Leflunomide is a solid.

Melting point (Celsius)
160.50
Melting point (Kelvin)
433.65
Boiling point (Celsius)
370.15
Boiling point (Kelvin)
643.30
General information
Molecular weight
270.18g/mol
Molar mass
270.1580g/mol
Density
1.4690g/cm3
Appearence

Leflunomide is typically observed as a white to off-white crystalline powder.

Comment on solubility

Solubility of N-(3,4-dichlorophenyl)-1-ethylsulfanyl-methanimidothioic acid

N-(3,4-dichlorophenyl)-1-ethylsulfanyl-methanimidothioic acid is a compound that exhibits unique solubility characteristics, making it a subject of interest in various chemical studies. The solubility of this compound can be influenced by several factors:

  • Polarity: The presence of both polar and nonpolar functional groups in the structure can lead to variable solubility in different solvents.
  • Solvent Effects: It tends to be more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or acetone due to their ability to disrupt molecular interactions.
  • Aqueous Solubility: Generally, this compound is expected to have low solubility in water, as thio acids typically show limited dissolution in polar solvents.
  • Temperature Dependence: Increasing the temperature may enhance the solubility in certain solvents, a common behavior observed in many organic compounds.

This compound presents a challenge in achieving optimal solubility, which may necessitate the use of co-solvents or specialized solvent mixtures. As the saying goes, "Like dissolves like," hence understanding the chemical nature of both the solute and the solvent is crucial for practical applications.

In summary, the solubility of N-(3,4-dichlorophenyl)-1-ethylsulfanyl-methanimidothioic acid is fundamentally influenced by:

  1. Types of solvents used.
  2. Temperature conditions.
  3. Molecular interactions within the compound.

Investigations into this solubility behavior may provide insights into its practical applications in chemical synthesis and formulation development.

Interesting facts

Interesting Facts about N-(3,4-Dichlorophenyl)-1-ethylsulfanyl-methanimidothioic Acid

N-(3,4-Dichlorophenyl)-1-ethylsulfanyl-methanimidothioic acid is a fascinating compound with several intriguing attributes that make it a topic of interest in the fields of chemistry and pharmacology. Here are some key points about this unique compound:

  • Structure and Composition: This compound is characterized by its complex structure, which includes a dichlorophenyl group and an ethylthio substituent. The presence of sulfur in its structure adds to its unique reactivity and potential biological activity.
  • Biological Significance: Compounds containing sulfur are often known to exhibit diverse biological properties. N-(3,4-dichlorophenyl)-1-ethylsulfanyl-methanimidothioic acid may demonstrate potential as a bioactive agent, with implications in pharmaceuticals and agrochemicals.
  • Potential Applications: Research suggests that similar thioic acid derivatives can be useful in developing herbicides and pesticides. The incorporation of the dichloro group may enhance the stability and efficacy of the compound in various applications.
  • Mechanism of Action: Investigations into related compounds often reveal diverse mechanisms, potentially involving the inhibition of specific enzymatic pathways, making this compound a candidate for future studies aimed at drug design and agricultural applications.
  • Environmental Considerations: The environmental impact of synthesizing and using compounds like this one warrants attention. Understanding the persistence and degradation of thioic acids in ecosystems is crucial for promoting sustainability in chemistry.

In conclusion, N-(3,4-Dichlorophenyl)-1-ethylsulfanyl-methanimidothioic acid not only embodies a complex molecular architecture but also opens pathways for further research into its biological and environmental interactions, making it a compelling subject in the study of chemical compounds.