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Diclofenamide

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Identification
Molecular formula
C8H7Cl2NO
CAS number
120-97-8
IUPAC name
N-(3,4-dichlorophenyl)acetamide
State
State

At room temperature, diclofenamide is a solid. It is stable under normal conditions and can be stored without significant risk of degradation.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
267.00
Boiling point (Kelvin)
540.15
General information
Molecular weight
204.05g/mol
Molar mass
204.0690g/mol
Density
1.5150g/cm3
Appearence

Diclofenamide typically appears as a white to off-white crystalline solid. It is odorless and has a slightly bitter taste. It is generally supplied in powder form for medical and laboratory use.

Comment on solubility

Solubility of N-(3,4-dichlorophenyl)acetamide

N-(3,4-dichlorophenyl)acetamide, with the chemical formula C9H8Cl2N2O, exhibits intriguing solubility characteristics that can be influenced by several factors:

  • Solvent Polarity: This compound is generally soluble in organic solvents due to its aromatic structure and polar amide functional group. Common solvents include:
    • Dimethyl sulfoxide (DMSO)
    • Acetone
    • Ethyl acetate
  • Water Solubility: However, N-(3,4-dichlorophenyl)acetamide has limited solubility in water. This can be attributed to:
    • The presence of the chlorinated benzene ring, which reduces its ability to interact with water molecules.
    • The overall hydrophobic character of the aromatic system.
  • Temperature Influence: Solubility can also vary with temperature. Generally, an increase in temperature enhances the solubility of solid compounds in solvents.
  • pH Dependence: Being an amide, the solubility of this compound may further fluctuate based on the pH of the solution, although significant changes are less likely under neutral conditions.

In conclusion, while N-(3,4-dichlorophenyl)acetamide shows good solubility in organic solvents, its interaction with water remains limited due to its chemical structure. Understanding these solubility properties is crucial for its application in various chemical processes.

Interesting facts

Interesting Facts about N-(3,4-Dichlorophenyl)acetamide

N-(3,4-Dichlorophenyl)acetamide, often referred to as a derivative of acetamide, holds a significant place in organic chemistry and pharmaceutical applications. Below are some compelling facts about this intriguing compound:

  • Pharmacological Relevance: N-(3,4-Dichlorophenyl)acetamide has been studied for its potential biological activities, including analgesic and anti-inflammatory properties. Its structural similarities with other drug candidates make it a valuable compound in medicinal chemistry.
  • Structure Activity Relationship (SAR): The presence of dichloro groups on the phenyl ring is crucial in modulating the compound's activity. The specific positions of these substituents can drastically alter the compound's pharmacological profile.
  • Applications in Synthesis: This compound can serve as an intermediate in the synthesis of more complex molecules, showcasing its versatility in organic reactions. Scientists leverage its structure to build libraries of related compounds for drug discovery.
  • Environmental Impact: As with many chlorinated compounds, the environmental behavior of N-(3,4-Dichlorophenyl)acetamide deserves attention. The stability of chlorinated aromatics raises concerns regarding bioaccumulation and toxicity.

As noted by chemists, "The beauty of organic compounds lies in their ability to unlock new possibilities in drug design and development." This statement resonates particularly well with N-(3,4-Dichlorophenyl)acetamide, a compound that exemplifies the profound impact of molecular structure on biological function.

Through ongoing research and exploration, we continue to uncover the potential of compounds like N-(3,4-Dichlorophenyl)acetamide, paving the way for advancements in medicine and chemistry.

Synonyms
N-(3,4-DICHLOROPHENYL)ACETAMIDE
2150-93-8
3,4-Dichloroacetanilide
3',4'-Dichloroacetanilide
N-acetyl-3,4-dichloroaniline
Acetanilide, 3',4'-dichloro-
N6H98GF14R
NSC 30069
NSC-17008
NSC-30069
DTXSID00175843
NSC 17008
Acetanilide (8CI), 3',4'-dichloro-
AI3-31362
Acetamide (9CI), N-(3,4-dichlorophenyl)-
DTXCID6098334
654-500-4
N-(3,4-Dichloro-phenyl)-acetamide
Acetamide, N-(3,4-dichlorophenyl)-
TCMDC-125481
MFCD00018148
NSC17008
Maybridge4_003067
UNII-N6H98GF14R
CHEMBL579571
SCHEMBL4548035
CCG-351
CHEBI:195037
SCYGGCAQZFJGRF-UHFFFAOYSA-N
Acetanilide (8CI),4'-dichloro-
HMS1529L09
CAA15093
NSC30069
AB6994
Acetamide (9CI),4-dichlorophenyl)-
AKOS001044969
9J-545S
SB35413
NCGC00176247-01
NCI60_002522
SY104228
DB-265710
CS-0168011
EN300-234244
BRD-K56517575-001-01-4
Q27284628
Z28128347
3 inverted exclamation mark ,4 inverted exclamation mark -Dichloroacetanilide