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Alfuzosin

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Identification
Molecular formula
C19H27N3O4S
CAS number
81403-80-7
IUPAC name
N-[4-[1-hydroxy-2-(methylamino)propyl]phenyl]methanesulfonamide
State
State

At room temperature, alfuzosin is typically in a solid state, appearing as a fine powder. It is stable under normal storage conditions, which are cool and dry environments away from direct sunlight.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
214.00
Boiling point (Kelvin)
487.15
General information
Molecular weight
389.50g/mol
Molar mass
389.4970g/mol
Density
0.8565g/cm3
Appearence

Alfuzosin appears as a white to off-white crystalline powder. It is odorless and has a bitter taste. The compound is usually provided in its hydrochloride salt form for pharmaceutical use.

Comment on solubility

Solubility of N-[4-[1-hydroxy-2-(methylamino)propyl]phenyl]methanesulfonamide

N-[4-[1-hydroxy-2-(methylamino)propyl]phenyl]methanesulfonamide is a fascinating compound characterized by its unique structural properties, which can significantly influence its solubility in various solvents.

Factors Affecting Solubility

The solubility of this compound can be analyzed based on several key factors:

  • Polarity: Compounds with polar functional groups, such as hydroxyl and amino groups, typically exhibit greater solubility in polar solvents.
  • Hydrogen Bonding: The presence of the -OH group allows for hydrogen bonding, enhancing solubility in water by stabilizing interactions with solvent molecules.
  • Molecular Structure: The size and complexity of the molecule can affect packing and interactions in solution. Bulky groups may hinder solubility.

As a general expectation, one might say that:

  • N-[4-[1-hydroxy-2-(methylamino)propyl]phenyl]methanesulfonamide will likely be more soluble in water due to its polar characteristics.
  • In contrast, solubility in nonpolar solvents may be limited as the hydrophobic regions do not favor interactions.

In summary, while specific solubility data for this compound under various conditions may not be readily available, its unique functional groups strongly suggest enhanced solubility in polar environments, making it exceptionally relevant for applications in pharmaceuticals and related fields.

Interesting facts

Interesting Facts About N-[4-[1-hydroxy-2-(methylamino)propyl]phenyl]methanesulfonamide

N-[4-[1-hydroxy-2-(methylamino)propyl]phenyl]methanesulfonamide is a notable compound that has attracted the attention of scientists and researchers in various fields, such as pharmaceuticals and organic chemistry. Here are some intriguing aspects of this compound:

  • Pharmaceutical Relevance: This compound is linked to various therapeutic applications, particularly in the realm of anti-inflammatory and analgesic drugs. Its structure allows for interactions with biological systems that may lead to beneficial effects.
  • Functional Groups: The presence of both a sulfonamide group and a hydroxyl group in its structure enhances its chemical reactivity and allows for diverse applications in synthesis and biological activity.
  • Structure-Activity Relationship (SAR): The unique features of the molecule enable researchers to modify its structure to improve potency or reduce side effects, which is a key aspect in drug design.
  • Research Focus: Ongoing studies are aimed at understanding the mechanisms of action of this compound and its derivatives, which could lead to the development of new treatments for various conditions.

In the words of a prominent chemist, "The ability to tailor compounds to achieve desired biological effects is at the heart of medicinal chemistry." The exploration of N-[4-[1-hydroxy-2-(methylamino)propyl]phenyl]methanesulfonamide highlights the delicate balance between molecular structure and its resulting pharmacological properties.

As a compound with complex characteristics, it exemplifies the intricacies of chemical science, driving innovative solutions in healthcare and therapeutic advancements.

Synonyms
METALOL
7701-65-7
N-[4-[1-hydroxy-2-(methylamino)propyl]phenyl]methanesulfonamide
N-{4-[1-HYDROXY-2-(METHYLAMINO)PROPYL]PHENYL}METHANESULFONAMIDE
SCHEMBL613921
CHEMBL2110946
BDBM81451
4'-(1-Hydroxy-2-(methylamino)propyl)methanesulfonanilide
DTXSID00998296
PDSP1_000162
PDSP2_000161
CAS_120852
NSC_120852
MJ-1998,(+/-)