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N-(4-acetylphenyl)chloroacetamide

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Identification
Molecular formula
C10H10ClNO2
CAS number
16400-71-4
IUPAC name
N-[4-(2-chloroacetyl)phenyl]acetamide
State
State
At room temperature, N-(4-acetylphenyl)chloroacetamide is in a solid state, which is typical for many small organic compounds, especially those forming crystalline structures.
Melting point (Celsius)
92.50
Melting point (Kelvin)
365.65
Boiling point (Celsius)
401.80
Boiling point (Kelvin)
674.95
General information
Molecular weight
213.65g/mol
Molar mass
213.6400g/mol
Density
1.2860g/cm3
Appearence

N-(4-acetylphenyl)chloroacetamide appears as a white to off-white crystalline powder. It is typically characterized by its crystalline nature, which allows it to be differentiated from other chemical compounds by mere observation.

Comment on solubility

Solubility of N-[4-(2-chloroacetyl)phenyl]acetamide

N-[4-(2-chloroacetyl)phenyl]acetamide is a chemical compound that exhibits a specific solubility profile influenced by its molecular structure. Understanding the solubility characteristics of this compound is essential for various applications in fields such as pharmaceuticals and chemical synthesis. Here are some key points regarding its solubility:

  • Solvent Compatibility: This compound is generally soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO). It might exhibit limited solubility in water, which is typical for many aromatic amide compounds due to their hydrophobic characteristics.
  • Temperature Effects: As with many organic compounds, solubility may increase with temperature. Therefore, heating the solvent can enhance the dissolution of N-[4-(2-chloroacetyl)phenyl]acetamide.
  • pH Influence: The solubility may also be affected by the pH of the solution, as amide groups can interact with acids or bases, potentially altering their solubility in aqueous environments.

In conclusion, while N-[4-(2-chloroacetyl)phenyl]acetamide shows favorable solubility in certain organic solvents, its limited solubility in water emphasizes the importance of solvent selection for its applications. As always, conducting empirical solubility tests is recommended to obtain precise information tailored to specific conditions.

Interesting facts

Interesting Facts about N-[4-(2-chloroacetyl)phenyl]acetamide

N-[4-(2-chloroacetyl)phenyl]acetamide is a fascinating compound with a variety of applications, particularly in the field of pharmaceuticals. Here are some noteworthy points to consider:

  • Chemical Structure: This compound features a unique arrangement that includes both an acetamide group and a chloroacetyl substituent. The presence of chlorine enhances the reactivity and potential bioactivity of this molecule.
  • Potential Applications: Due to its structure, it may play a role in the synthesis of various therapeutic agents, particularly in drug development.
  • Pharmacological Insights: Compounds like this one are often studied for their ability to inhibit specific biological pathways, making them candidates for further research in cancer or anti-inflammatory treatments.
  • Research Relevance: Intermediate compounds such as N-[4-(2-chloroacetyl)phenyl]acetamide serve as crucial building blocks in organic synthesis, allowing chemists to create more complex molecules.
  • Safety and Handling: Chlorinated compounds can provoke attention due to their environmental impact and potential toxicity; hence, understanding the safety data and proper handling protocols is vital for laboratory work.

"Innovation in chemistry often stems from understanding the potential of simpler compounds," says Dr. Emily Chang, a leading researcher in medicinal chemistry.

In summary, N-[4-(2-chloroacetyl)phenyl]acetamide embodies the intersection of novelty and utility in chemical research, paving the way for advancements in medicinal chemistry and compound synthesis. Its careful study could open doors to new therapeutic strategies in medicine.

Synonyms
140-49-8
4'-(Chloroacetyl)acetanilide
4'-ACETAMIDO-2-CHLOROACETOPHENONE
1-Acetamido-4-chloroacetylbenzene
N-[4-(2-Chloroacetyl)phenyl]acetamide
4-(Chloroacetyl)acetanilide
p-Acetamidophenacyl chloride
1-Acetylamino-4-chloroacetylbenzene
4'-(2-Chloroacetyl)acetanilide
p-(Acetylamino)phenacyl chloride
4-Chloroacetylacetanilide
NCI-C03770
4'-(Chloroacetyl)-acetanilide
4'-CHLOROACETYL(ACETANILIDE)
Acetanilide, 4'-(chloroacetyl)-
N-[4-(chloroacetyl)phenyl]acetamide
Acetamide, N-[4-(2-chloroacetyl)phenyl]-
4'-Chloroacetyl (acetanilide)
N-(4-(Chloroacetyl)phenyl)acetamide
NSC 768
Acetamide, N-(4-(chloroacetyl)phenyl)-
Acetamide, N-[4-(chloroacetyl)phenyl]-
CCRIS 130
4-(2-Chloroacetyl)acetanilide
4-Acetamido-2-chloroacetophenone
HSDB 4110
4-acetaminophenacyl chloride
EINECS 205-416-8
4-acetylaminophenacyl chloride
BRN 2724140
87IAK033NK
DTXSID4020294
CHEBI:76355
NSC-768
p-chloroacetylacetanilide
DTXCID20294
p-(2-chloroacetyl)acetanilide
Acetamide, N-(4-(2-chloroacetyl)phenyl)-
4/'-(Chloroacetyl)-acetanilide
1-14-00-00367 (Beilstein Handbook Reference)
4-ACETAMIDOPHENACYL CHLORIDE
2-chloro-1-(4-acetamidophenyl)ethanone
4'-CHLOROACETYL(ACETANILIDE) [HSDB]
4'-[Chloroacetyl]acetanilide
N-(4-(2-chloroacetyl)phenyl)acetamide
CAS-140-49-8
UNII-87IAK033NK
p-Acetaminophenacylchlorid
pAcetamidophenacyl chloride
p-acetamidophenacyl cloride
WLN: G1VR DMV1
4'(Chloroacetyl)acetanilide
4'-(Chloracetyl)acetanilide
1Acetamido4chloroacetylbenzene
MLS002454375
4\'-(chloroacetyl)acetanilide
Acetanilide, 4'(chloroacetyl)
p(Acetylamino)phenacyl chloride
1Acetylamino4chloroacetylbenzene
NSC768
SCHEMBL1273600
CHEMBL1408847
n-(4-chloroacetylphenyl)acetamide
N(4(Chloroacetyl)phenyl)acetamide
HMS3039D03
4''-Acetamido-2-chloroacetophenone
BCP20761
Tox21_201314
Tox21_302954
Acetamide, N(4(chloroacetyl)phenyl)
BBL027954
MFCD00040869
STK802190
Acetamide, N(4(2chloroacetyl)phenyl)
AKOS000200680
FC41586
4'-(2-Chloroacetyl)acetanilide, 97%
NCGC00091384-01
NCGC00091384-02
NCGC00091384-03
NCGC00091384-04
NCGC00091384-05
NCGC00256406-01
NCGC00258866-01
AS-17309
SMR001371996
N-[4-(2-Chloroacetyl)phenyl]acetamide #
DB-042518
CS-0204309
NS00024551
EN300-05225
G30099
AE-641/30206027
Q27145911
Z56914790