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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy-benzamide
State
State

At room temperature, lidocaine is typically found as a solid in the form of a powder. It can also be prepared as a liquid formulation for medical use, where it is often administered as an injectable local anesthetic.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.80
Boiling point (Kelvin)
623.95
General information
Molecular weight
234.34g/mol
Molar mass
234.3370g/mol
Density
1.0300g/cm3
Appearence

Lidocaine is typically an odorless, white crystalline powder. In some forms, it may appear as a white liquid, especially when used in medical formulations as an injectable solution.

Comment on solubility

Solubility of N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy-benzamide

The solubility of N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy-benzamide (C14H22N2O) can be influenced by several key factors:

  • Polarity: The presence of both polar and non-polar functional groups within the molecule significantly affects its solubility in various solvents. The dimethylamino and ethoxy groups add polar characteristics, which can improve solubility in polar solvents.
  • Temperature: As with many organic compounds, an increase in temperature generally enhances solubility. Dissolving the compound at higher temperatures might lead to better solubility profiles in chosen solvents.
  • pH Levels: The solution's pH can play a crucial role, especially for amine-containing compounds. Adjusting the pH may alter ionization states, affecting solubility.

In terms of practical applications, it is essential to ascertain if this compound is more soluble in organic solvents (like ethanol or DMSO) or aqueous solutions. A preliminary understanding indicates that compounds with similar structures often exhibit:

  1. Increased solubility in polar organic solvents.
  2. Limited solubility in non-polar solvents.

To summarize, while the specific solubility data for this compound may vary, understanding its solubility can guide practical applications in chemical formulations and therapeutic design. Testing in selected solvents will provide a clearer picture of its solubility behaviors.

Interesting facts

Interesting Facts About N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy-benzamide

This compound, known for its complex structure and intriguing properties, plays a significant role in chemical research and pharmaceutical applications. Its formulation demonstrates how even slight changes in molecular architecture can lead to profound differences in biological activity.

Key Features

  • Pharmacological Potential: This compound belongs to a class of benzamide derivatives that are often studied for their potential pharmacological benefits, including antitumor and anti-inflammatory properties.
  • Structure-Activity Relationship: The presence of the dimethylamino group significantly influences the compound's interaction with biological targets, making it a subject of interest in medicinal chemistry.
  • Versatile Functional Groups: The incorporation of various functional groups, such as methoxy and ethoxy, enhances its chemical reactivity and solubility profile, which is vital for drug design.
  • Significance in Drug Development: Compounds like this one are crucial in scaffold screening for new drug candidates, showcasing the importance of chemical diversity in medicinal chemistry.

Research Highlights

Studies have revealed that compounds with similar structural motifs can:

  • Exhibit selective inhibition of certain enzymes.
  • Act as potential leads for developing new treatments for various diseases.
  • Show differences in bioavailability, affecting their efficacy in therapeutic applications.

The exploration of this compound can lead scientists to discover novel pathways and mechanisms in drug action. As emphasized by renowned chemist Linus Pauling, "Chemistry is the study of transformations", and indeed, the transformation of this molecular structure is a thrilling journey in the realm of chemical sciences.

As research continues, we can anticipate exciting developments that may arise from the study of N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy-benzamide, forging new pathways in pharmacology and therapeutic treatments.

Synonyms
Itopride
122898-67-3
N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4-dimethoxybenzamide
Itopride [INN]
itoprida
UNII-81BMQ80QRL
Itopride free base
81BMQ80QRL
Itopride (INN)
NSC-759643
Itax
N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide
ITOPRIDE [MI]
n-{4-[2-(dimethylamino)ethoxy]benzyl}-3,4-dimethoxybenzamide
ITOPRIDE [WHO-DD]
N-(p-(2-(Dimethylamino)ethoxy)benzyl)veratramide
DTXSID7048320
N-({4-[2-(dimethylamino)ethoxy]phenyl}methyl)-3,4-dimethoxybenzamide
122898-67-3 (free base)
NSC 759643
Hsr 803
Benzamide, N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy-
SR-01000763470
NCGC00167529-01
itopridum
N-[4-[2-(Dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide
N-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxybenzamide
SCHEMBL311309
CHEMBL2107457
DTXCID5028295
CHEBI:94809
HY-B0732A
HMS2090M18
HMS3264A06
HMS3713O06
Pharmakon1600-01502353
BCP12218
STR09779
NSC759643
STL483803
AKOS022172837
CCG-213830
DB04924
DB-041695
CS-0013633
NS00017269
D08094
AB00698504-07
AB00698504-09
AB00698504_10
EN300-6492966
L002674
Q4409774
SR-01000763470-3
SR-01000763470-4
BRD-K96740444-001-02-1
Z667612124