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Atenolol

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Identification
Molecular formula
C14H22N2O3
CAS number
29122-68-7
IUPAC name
N-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide
State
State

At room temperature, atenolol is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
152.00
Melting point (Kelvin)
425.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
266.34g/mol
Molar mass
266.3360g/mol
Density
1.1800g/cm3
Appearence

Atenolol is typically seen as a white or almost white crystalline powder that is odorless.

Comment on solubility

Solubility of N-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide (C14H22N2O3)

The solubility of N-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide presents some interesting characteristics due to its complex molecular structure. This compound contains both hydrophilic and hydrophobic components, which play crucial roles in its solubility profile.

  • Hydrophilic Features: The presence of the hydroxyl group (-OH) and the amine group (-NH) greatly enhances the solubility in polar solvents such as water. These groups can form hydrogen bonds, facilitating interaction with water molecules.
  • Hydrophobic Features: The isopropyl group contributes hydrophobic characteristics, which may limit solubility in water but can enhance solubility in organic solvents such as ethanol or DMSO.

Overall, the solubility of this compound can be summed up as follows:

  1. Moderately soluble in water due to the presence of polar functional groups.
  2. Highly soluble in organic solvents that can accommodate both hydrophilic and hydrophobic interactions.
  3. Presents unique properties that may affect its bioavailability in pharmaceutical applications.

In conclusion, the solubility of N-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide is a fascinating balance between hydrophilic and hydrophobic interactions, making it versatile for various applications.

Interesting facts

Interesting Facts about N-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide

N-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide is a fascinating compound that plays a significant role in medicinal chemistry and pharmaceuticals. Here are some interesting points to consider:

  • Pharmacological Properties: This compound is recognized for its potential use in various therapeutic applications, particularly as an analgesic and anti-inflammatory agent. Its structure allows for interactions with biological targets that modulate pain perception.
  • Structure-Activity Relationship: The unique arrangement of functional groups, including the isopropylamino moiety, affords the compound its activity. Understanding how modifications to these groups influence efficacy is crucial for drug design.
  • Hydrophilicity: The presence of a hydroxyl group enhances the compound's solubility and interactions with biological membranes, making it a valuable candidate for formulation in drug delivery systems.
  • Research Applications: Ongoing research is focusing on the optimization of its pharmacokinetic profile, aiming to increase its bioavailability and reduce potential side effects.
  • Historical Context: Compounds similar to N-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide have been pivotal in the development of non-steroidal anti-inflammatory drugs (NSAIDs), which are crucial in managing pain and inflammation globally.

As a student of chemistry or a scientist, it’s fascinating to explore the depth of this compound’s applications and the ongoing research that continues to unveil its full potential. The synthesis and modification of such compounds are essential in advancing medical science and improving patient outcomes.

Synonyms
practolol
6673-35-4
Dalzic
Eraldin
Teranol
Practololum
Praktololu
dl-Practolol
Practololo
Practololo [DCIT]
rac Practolol
Praktololu [Polish]
Practololum [INN-Latin]
N-[4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETAMIDE
AY 21011
ICI 50172
ICI-50172
1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol
N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
(+-)-Practolol
(+/-)-Practolol
4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide
CCRIS 1089
Practalol
N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide
UNII-SUG9176GRW
N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide
N-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide
EINECS 229-712-1
SUG9176GRW
Practolol [USAN:INN:BAN]
Practolol (USAN)
N-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide
AY-21011
DTXSID0021179
AY-21,011
I.C.I. 50,172
Acetamide, N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-
CHEBI:258351
PRACTOLOL [INN]
PRACTOLOL [MI]
PRACTOLOL [USAN]
PRACTOLOL [MART.]
PRACTOLOL [WHO-DD]
CHEMBL6995
I.C.I.-50,172
DTXCID001179
Acetamide, N-[4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-
4'-[2-Hydroxy-3-(Isopropylamino)propoxy]acetanilide
Acetanilide, 4'-(2-hydroxy-3-(isopropylamino)propoxy)-
Acetanilide, 4'-[2-hydroxy-3-(isopropylamino)propoxy]-
NCGC00024810-02
N-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide
Practololum (INN-Latin)
PRACTOLOL (MART.)
4-[2-Hydroxy-3-(isopropylamino)propoxy]-acetanilide
DL-4'-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)ACETANILIDE
Prestwick_742
Spectrum_001454
SR-01000597449
4-(2-Hydroxy-3-(isopropylamino)propoxy)-acetanilide
N-(4-(2-hydroxy-3-(propan-2-ylamino)propoxy)phenyl)acetamide
(3-(4-Acetylamino-Phenoxy)-2-Hydroxy-Propyl)-Isopropyl-Ammonium
[3-(4-Acetylamino-phenoxy)-2-hydroxy-propyl]-isopropyl-ammonium
N-(4-(2-hydroxy-3-((propan-2-yl)amino)propoxy)phenyl)acetamide
Practolol,(+)
Practolol,(-)
CAS-6673-35-4
Practolol (Standard)
Prestwick0_000332
Prestwick1_000332
Prestwick2_000332
Prestwick3_000332
Spectrum2_001572
Spectrum4_000859
Spectrum5_001123
N-[4-({2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]acetamide
Oprea1_095524
SCHEMBL39925
BSPBio_000363
GTPL555
KBioGR_001497
KBioSS_001934
MLS002153779
DivK1c_000901
SPBio_001504
SPBio_002284
BPBio1_000401
Practolol, >=95% (HPLC)
BDBM25749
HMS502N03
KBio1_000901
KBio2_001934
KBio2_004502
KBio2_007070
NINDS_000901
HMS1569C05
HMS2089I09
HMS2096C05
HMS2233K23
HMS3374G04
HMS3713C05
ALBB-033372
Tox21_110928
CCG-39350
STL489279
AKOS002685374
AKOS016054902
Tox21_110928_1
DB01297
HY-119802R
IDI1_000901
NCGC00024810-03
NCGC00024810-04
NCGC00024810-07
AC-37857
LS-12647
SMR001233163
SBI-0051937.P002
DB-231424
HY-119802
AB00052459
CS-0078043
EN300-72170
D05587
G12676
L000491
Q7237376
SR-01000597449-1
SR-01000597449-2
SR-01000597449-4
BRD-A41304429-001-04-9
BRD-A41304429-001-12-2
BRD-A41304429-001-14-8
BRD-A41304429-001-17-1
Z274728816
N-(4-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl)acetamide #
229-712-1