Skip to main content

Paracetamol sulfide

ADVERTISEMENT
Identification
Molecular formula
C16H16N2O3S
CAS number
61336-70-7
IUPAC name
N-[4-[2-nitro-1-(p-tolylsulfanyl)ethyl]phenyl]acetamide
State
State

At room temperature, this compound is found in a solid state, specifically as a crystalline powder. It does not easily vaporize and should be handled with care to prevent inhalation or contact with skin due to its potential hazardous nature when powdered and airborne.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.20
Boiling point (Celsius)
364.70
Boiling point (Kelvin)
637.90
General information
Molecular weight
331.38g/mol
Molar mass
331.3800g/mol
Density
1.3900g/cm3
Appearence

Pure N-[4-[2-nitro-1-(p-tolylsulfanyl)ethyl]phenyl]acetamide is typically a crystalline powder, often found in a white to off-white color. It can also have a slight yellowish tint if impurities are present. The compound should be stored in a low-moisture environment to prevent any discoloration or degradation.

Comment on solubility

Solubility of N-[4-[2-nitro-1-(p-tolylsulfanyl)ethyl]phenyl]acetamide

N-[4-[2-nitro-1-(p-tolylsulfanyl)ethyl]phenyl]acetamide, with a complex structure, presents unique challenges regarding its solubility. The compound's solubility can be influenced by several factors:

  • Polarity: The presence of the nitro group (−NO2) introduces polar characteristics, which can enhance solubility in polar solvents.
  • Hydrophobicity: The aromatic rings and p-tolylsulfanyl substituent contribute hydrophobic traits, often making the compound less soluble in water but more soluble in organic solvents.
  • Temperature: Generally, solubility tends to increase with temperature. Thus, heating the solvent may allow for greater dissolution of the compound.
  • pH Effects: Depending on the environment's acidity or basicity, the compound's solubility can vary significantly, reflecting changes in ionization or interaction with solvent molecules.

In practical applications, this compound may exhibit limited solubility in aqueous environments while being more readily soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO). It is important to take these factors into account when preparing solutions for experimental use.

Interesting facts

Interesting Facts about N-[4-[2-nitro-1-(p-tolylsulfanyl)ethyl]phenyl]acetamide

N-[4-[2-nitro-1-(p-tolylsulfanyl)ethyl]phenyl]acetamide is a complex compound that showcases the fascinating intersection of organic chemistry and medicinal applications. This particular compound belongs to a class of molecules that include functional groups, granting it significant potential in various fields. Here are some noteworthy points about this compound:

  • Versatile Structure: The presence of a nitro group (–NO2) and sulfonyl group creates a versatility that can be exploited in several chemical transformations and biological activities.
  • Pharmaceutical Relevance: Compounds containing sulfur and nitro groups are often investigated for their potential in drug development, particularly due to their unique reactivity and ability to interact with biological targets.
  • Potential for Synthesis: The synthesis of this compound may involve multiple reaction steps, including nucleophilic substitutions and acylations, making it a great project for students looking to enhance their laboratory skills.
  • Reactivity: As a nitro compound, it is likely to undergo reduction reactions, opening avenues for further derivatization and the exploration of related compounds.
  • Structure-Activity Relationship (SAR): Understanding how structural modifications affect biological activity can lead to the development of more effective derivatives, bolstering research in medicinal chemistry.

In summary, N-[4-[2-nitro-1-(p-tolylsulfanyl)ethyl]phenyl]acetamide represents an intriguing subject of study, showcasing the intricate interplay of chemical structure and potential pharmacological properties. Its unique attributes render it a valuable compound for ongoing research and educational pursuits in the field of chemistry.

Synonyms
20404-97-1
BRN 2770031
4'-(2-Nitro-1-(p-tolylthio)ethyl)acetanilide
U-3243
ACETANILIDE, 4'-(2-NITRO-1-(p-TOLYLTHIO)ETHYL)-
Acetamide, N-((1-((4-methylphenyl)thio)-2-nitroethyl)phenyl)-
Acetamide, N-((1-((4-methylphenyl)thio)-2-nitroethyl)phenyl)-(9CI)
RefChem:314841
DTXSID80942570
N-(4-{1-[(4-Methylphenyl)sulfanyl]-2-nitroethyl}phenyl)ethanimidic acid