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Carvedilol

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Identification
Molecular formula
C24H26Cl2N2O4
CAS number
72956-09-3
IUPAC name
N-[4-[3-[2-(3,4-dichlorophenyl)ethyl-methyl-amino]-2-hydroxy-propoxy]phenyl]methanesulfonamide
State
State

Solid at room temperature.

Melting point (Celsius)
114.00
Melting point (Kelvin)
387.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
406.48g/mol
Molar mass
406.4730g/mol
Density
1.2253g/cm3
Appearence

Carvedilol appears as a white to off-white crystalline powder. It is slightly soluble in water, soluble in alcohol, and very soluble in dimethyl sulfoxide (DMSO) and dimethylformamide (DMF).

Comment on solubility

Solubility of N-[4-[3-[2-(3,4-dichlorophenyl)ethyl-methyl-amino]-2-hydroxy-propoxy]phenyl]methanesulfonamide (C24H26Cl2N2O4)

The solubility of N-[4-[3-[2-(3,4-dichlorophenyl)ethyl-methyl-amino]-2-hydroxy-propoxy]phenyl]methanesulfonamide in various solvents can be influenced by several factors including its chemical structure and functional groups. Here are some key points regarding its solubility:

  • Polarity: The presence of polar functional groups, such as hydroxyl (–OH) and sulfonamide (–SO2NH2), suggests that this compound may exhibit moderate solubility in polar solvents like water.
  • Halogen Atoms: The dichlorophenyl moiety may lead to enhanced solubility in organic solvents due to its hydrophobic character, making it more soluble in nonpolar solvents.
  • pH Dependence: The solubility could be affected by the pH of the solution, with potential ionization of the amine group under acidic or basic conditions, potentially enhancing its aqueous solubility.
  • Strictures: The overall molecular weight and size can also affect solubility; larger molecules tend to have lower solubility due to steric hindrance.

In summary, the overall solubility of this compound is likely to be moderate in water and potentially higher in organic solvents. Understanding its solubility profile is crucial for its applications in pharmaceuticals and related fields.

Interesting facts

Interesting Facts About N-[4-[3-[2-(3,4-Dichlorophenyl)ethyl-methyl-amino]-2-hydroxy-propoxy]phenyl]methanesulfonamide

N-[4-[3-[2-(3,4-dichlorophenyl)ethyl-methyl-amino]-2-hydroxy-propoxy]phenyl]methanesulfonamide, often referred to by its systematic name, is a fascinating chemical compound with diverse applications and properties.

Key Features

  • Drug Development: This compound belongs to a class of molecules that are often studied for their potential use in pharmaceutical applications, demonstrating promise in targeting specific biological pathways.
  • Structural Complexity: The molecular structure showcases several important functional groups, such as sulfonamides and chlorophenyl moieties, contributing to its reactivity and biological interaction.
  • Synthetic Chemistry: Researchers are often intrigued by the synthesis of such complex compounds, as they require multi-step synthetic methods that can provide insights into advanced organic chemistry.
  • Biological Activity: Compounds of similar structure have been linked to various biological activities, including anti-inflammatory and antimicrobial properties, making them subject to extensive pharmacological research.

Applications and Research

This compound serves as a prime example of how chemical modifications can lead to potent drugs. Investigations are often focused on:

  • Understanding the mechanism of action on cellular targets.
  • Studying the relationship between structure and biological activity, a central theme in medicinal chemistry.
  • Developing more efficient synthesis routes and analogs to enhance efficacy while minimizing side effects.

As research continues, this compound is expected to yield more insights into its full potential, demonstrating the interplay between chemistry, biology, and medicine.

In the words of a notable chemist, "The beauty of chemistry lies in its ability to create compounds that can impact life, often in incredibly rewarding ways." This compound embodies that beauty, holding promise for future discoveries.

Synonyms
133229-23-9
Msaph-2ClPhEA-2-propanol
1-(4-Methanesulfonamidophenoxy)-3-(N-methyl-3,4-dichlorophenylethylamino)-2-propanol
RV6721I4H5
UNII-RV6721I4H5
N-(4-(3-((2-(3,4-Dichlorophenyl)ethyl)methylamino)-2-hydroxypropoxy)phenyl)methanesulfonamide
Methanesulfonamide, N-(4-(3-((2-(3,4-dichlorophenyl)ethyl)methylamino)-2-hydroxypropoxy)phenyl)-
N-(4-(3-((3,4-dichlorophenethyl)(methyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
Bio2_000288
N-[4-[3-[2-(3,4-dichlorophenyl)ethyl-methylamino]-2-hydroxypropoxy]phenyl]methanesulfonamide
CBiol_001738
BSPBio_001568
KBioGR_000288
KBioSS_000288
CHEMBL43527
SCHEMBL9655059
CHEBI:91532
KBio2_000288
KBio2_002856
KBio2_005424
KBio3_000575
KBio3_000576
DTXSID10928009
Bio1_000024
Bio1_000513
Bio1_001002
Bio2_000768
HMS1791O10
HMS1989O10
AC-115
IDI1_034038
NCGC00024837-02
NCGC00024837-03
NCGC00024837-04
BRD-A11813248-001-02-8
BRD-A11813248-003-01-6
BRD-A11813248-003-02-4
Q27163366
N-[4-(3-{[2-(3,4-Dichloro-phenyl)-ethyl]-methyl-amino}-2-hydroxy-propoxy)-phenyl]-methanesulfonamide
N-[4-(3-{[2-(3,4-dichlorophenyl)ethyl](methyl)amino}-2-hydroxypropoxy)phenyl]methanesulfonamide