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N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide

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Identification
Molecular formula
C17H15BrN4O
CAS number
193344-82-2
IUPAC name
N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide
State
State

At room temperature, N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide typically exists as a solid substance.

Melting point (Celsius)
216.00
Melting point (Kelvin)
489.15
Boiling point (Celsius)
393.40
Boiling point (Kelvin)
666.55
General information
Molecular weight
373.23g/mol
Molar mass
373.2330g/mol
Density
1.4780g/cm3
Appearence

N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide appears as a crystalline solid. The color can range from off-white to beige, depending on the purity of the compound.

Comment on solubility

Solubility of N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide

N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide, with the chemical formula C17H15BrN4O, exhibits unique solubility characteristics, which are influenced by its complex molecular structure.

Key Solubility Insights:

  • Polarity: The presence of a bromine atom and multiple nitrogen atoms suggests that this compound may display different degrees of polarity, potentially affecting its solubility in various solvents.
  • Aqueous Solubility: Generally, compounds with similar structures may have limited solubility in water due to hydrophobic interactions, indicating that N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide might also exhibit low solubility in aqueous solutions.
  • Organic Solvents: It is likely that this compound could be more soluble in organic solvents such as dimethyl sulfoxide (DMSO), ethanol, or acetone, which can stabilize its structure.
  • Temperature Impact: Temperature can play a crucial role in enhancing the solubility of N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide in various solvents, where higher temperatures might promote better dissolution.

As indicated by the compound's structure, it is necessary to conduct experimental solubility tests to establish precise solubility data. Understanding its solubility behavior is essential for applications in pharmaceuticals, as it affects bioavailability and therapeutic effectiveness.

Interesting facts

Interesting Facts about N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide

N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide is a fascinating compound that belongs to a class of molecules known for their diverse biological activities. Here are some compelling facts about this compound:

  • Biological Significance: This compound is often explored for its potential as a therapeutic agent. Its structure allows for interactions that may inhibit certain enzymes or receptors, making it a candidate for drug development.
  • Structural Complexity: The quinazoline moiety provides a unique heterocyclic framework that contributes to the compound's biological properties. The presence of a bromine atom enhances its reactivity and can influence pharmacokinetic properties.
  • Research Applications: Compounds like this one are often included in studies aimed at understanding cancer and other diseases. Researchers are particularly interested in its role in modulating cellular mechanisms.
  • Synthetic Chemistry: The synthesis of this compound involves sophisticated techniques of organic chemistry, showcasing the intricate methodologies employed to produce such complex molecules.
  • Structure-Activity Relationship (SAR): Investigating the SAR of this compound can yield important insights into how modifications of the structure may enhance or alter its activity, guiding further optimization.

This compound exemplifies the intersection of chemistry and biology, highlighting how molecular structures can lead to advances in medical science. As research continues, the intricate dance of chemistry will hopefully unveil more secrets of its potential applications. As one researcher put it, "The beauty of chemistry lies in its ability to reveal complex interactions with the simplest of elements."

Synonyms
pd 174265
216163-53-0
N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamide
4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline
4-aminoquinazoline, 2a
PD-174265
CHEMBL188762
N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)propionamide
N-(4-((3-bromophenyl)amino)quinazolin-6-yl)propanamide
2hwp
3lok
N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide
BMC163482 Compound 3
GTPL6017
SCHEMBL2944459
BDBM31826
WUPUZEMRHDROEO-UHFFFAOYSA-N
HMS3229I05
HSCI1_000122
AKOS040749152
CCG-206770
SDCCGSBI-0086690.P003
DA-76650
MS-25970
HY-112411
CS-0045499
F81748
N-(4-(3-bromophenylamino)quinazolin-6-yl)propionamide
Q27088278
N-[4-(3-Bromo-phenylamino)-quinazolin-6-yl]propanamide
PD 174265 - CAS 216163-53-0