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Acetaminophen

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Identification
Molecular formula
C8H9NO2
CAS number
103-90-2
IUPAC name
N-[4-(4-acetamidophenyl)phenyl]acetamide
State
State

At room temperature, Acetaminophen is in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
327.00
Boiling point (Kelvin)
600.15
General information
Molecular weight
151.16g/mol
Molar mass
151.1630g/mol
Density
1.2630g/cm3
Appearence

Acetaminophen typically appears as a white, crystalline solid powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of N-[4-(4-acetamidophenyl)phenyl]acetamide

N-[4-(4-acetamidophenyl)phenyl]acetamide, often known for its intriguing structure, exhibits *moderate solubility* in various solvents. The solubility characteristics can be significantly influenced by the solvent's properties and the compound's functional groups. Here are some points to consider:

  • Aqueous solubility: Generally, compounds with amide functional groups can show variable solubility in water. The presence of acetamide moieties may enhance solubility, although the overall structure could lead to poor solubility.
  • Organic solvents: N-[4-(4-acetamidophenyl)phenyl]acetamide is likely to exhibit better solubility in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and acetonitrile due to its relatively hydrophobic characteristics.
  • Temperature effects: Solubility can also be affected by temperature; typically, increasing the temperature may improve the solubility in organic solvents.
  • Polarity considerations: Utilizing solvents with similar polarities may promote solubility, which can be particularly helpful when performing experiments or formulations.

In conclusion, understanding the solubility of N-[4-(4-acetamidophenyl)phenyl]acetamide is crucial for its practical applications. Experimentation is often key in defining its behavior in different media.

Interesting facts

Interesting Facts about N-[4-(4-acetamidophenyl)phenyl]acetamide

N-[4-(4-acetamidophenyl)phenyl]acetamide, commonly known for its role in drug development, is an intriguing compound that boasts a variety of applications in medicinal chemistry.

Key Properties and Applications

  • Pharmaceutical Relevance: This compound is often investigated in the context of its anti-inflammatory and analgesic properties, making it a candidate for pain relief medications.
  • Synthetic Pathways: The synthesis of N-[4-(4-acetamidophenyl)phenyl]acetamide involves reactions that are crucial for understanding amide formation and aromatic substitutions.
  • Structure-Activity Relationship (SAR): Scientists study how modifications to the acetamide and phenyl groups influence the biological activity, helping to optimize efficacy and reduce side effects.

Unique Characteristics

  • Versatile Functional Groups: The presence of both amide and acetamide functionalities allows for extensive interactions in biological systems, enhancing its pharmacological profile.
  • Potential for Derivatives: Researchers are interested in creating derivatives of this compound, as slight changes to its structure can yield significantly different biological activities.
  • Role in Research: This compound serves as a model for studying drug design and development, contributing to the foundational knowledge in medicinal chemistry.

In summary, N-[4-(4-acetamidophenyl)phenyl]acetamide is more than just a simple compound; it represents a rich area of study in the field of pharmaceuticals. Its properties and potential applications in therapeutic development continue to inspire researchers around the world. As one scientist aptly stated, "The journey of understanding a compound unfolds layers of complexity that can ultimately lead to life-changing discoveries."

Synonyms
N,N'-Diacetylbenzidine
N,N-Diacetylbenzidine
4,4'-DIACETYLBENZIDINE
CCRIS 197
Biphenyl, 4,4'-diacetamido-
HSDB 5078
Acetamide, N,N'-[1,1'-biphenyl]-4,4'-diylbis-
EINECS 210-338-2
UNII-2EE5599GQS
BRN 2217711
Acetamide, N,N'-(1,1'-biphenyl)-4,4'-diylbis-
AI3-08917
NSC-4717
N,N'-(1,1'-Biphenyl)-4,4'-diylbisacetamide
NSC-12409
DIACETYLBENZIDINE, N,N-
DTXSID9036854
4-13-00-00373 (Beilstein Handbook Reference)
4,4'-Diacetylamino-1,1'-biphenyl
N,N'-DIACETYLBENZIDINE [IARC]
4,4'-DIACETYLBENZIDINE [HSDB]
N,N'-[1,1'-biphenyl]-4,4'-diylbisacetamide
N,N'-DIACETYLBENZIDINE (IARC)
N,N'Diacetylbenzidine
N,N'Diacetyl benzidine
4,4'Diacetamidobiphenyl
4',4'''Biacetanilide
Benzidine, N,N'diacetyl
4,4'Diacetylaminobiphenyl
Biphenyl, 4,4'diacetamido
DTXCID7016854
N,N'4,4'Biphenylylenebisacetamide
Acetamide, N,N'4,4'biphenylylenebis
N,N'(1,1'Biphenyl)4,4'diylbisacetamide
Acetamide, N,N'(1,1'biphenyl)4,4'diylbis
czvhcfkuxgrabc-uhfffaoysa-n
613-35-4
Diacetylbenzidine
N,N'-Diacetyl benzidine
4,4'-Diacetamidobiphenyl
4',4'''-Biacetanilide
4,4'-Diacetylaminobiphenyl
Benzidine, N,N'-diacetyl-
N-[4-(4-acetamidophenyl)phenyl]acetamide
N,N'-4,4'-Biphenylylenebisacetamide
Acetamide, N,N'-4,4'-biphenylylenebis-
NSC 4717
NSC 12409
N,N'-(1,1'-Biphenyl)-4,4'-diylbis-acetamide
2EE5599GQS
N-(4'-Acetylamino-biphenyl-4-yl)-acetamide
CHEBI:82308
N,N'-(1,1'-Biphenyl)-4,4'-diylbis-acetamide 4',4'''-biacetanilide
Benzidine,N'-diacetyl-
WLN: 1VMR DR DMV1
N,4'-Biphenylylenebisacetamide
Acetamide,N'-4,4'-biphenylylenebis-
N,1'-Biphenyl)-4,4'-diylbis-acetamide
Acetamide,N'-[1,1'-biphenyl]-4,4'-diylbis-
N,N'-[1,1'-Biphenyl]-4,4'-diylbis-acetamide
Maybridge4_003199
Oprea1_734946
Oprea1_870996
CBDivE_014211
MLS000682798
SCHEMBL3818831
CHEMBL1567221
NSC4717
HMS1530B09
HMS2587G07
NSC12409
MFCD00048194
N,N'-biphenyl-4,4'-diyldiacetamide
STK122403
AKOS000495581
NCGC00176103-01
SMR000312155
DB-053844
CS-0362407
NS00034647
C19217
N,N'-([1,1'-biphenyl]-4,4'-diyl)diacetamide
N-{4'-acetamido-[1,1'-biphenyl]-4-yl}acetamide
SR-01000596885
N-[4'-(acetylamino)-1,1'-biphenyl-4-yl]acetamide
SR-01000596885-1
Q26840865
N-[4'-(Acetylamino)[1,1'-biphenyl]-4-yl]acetamide #