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Paracetamol

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Identification
Molecular formula
C8H9NO2
CAS number
103-90-2
IUPAC name
N-[4-(4-aminophenoxy)phenyl]acetamide
State
State

Paracetamol is found in a solid state at room temperature. It is commonly available as tablets, caplets, or as a powder.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
273.00
General information
Molecular weight
151.16g/mol
Molar mass
151.1630g/mol
Density
1.2637g/cm3
Appearence

Paracetamol appears as a white, crystalline powder that is practically odorless. It is often compacted into tablet form for pharmaceutical use, where it is also white and often shiny due to the presence of various coatings.

Comment on solubility

Solubility of N-[4-(4-aminophenoxy)phenyl]acetamide

N-[4-(4-aminophenoxy)phenyl]acetamide, often categorized as an aryl acetamide, exhibits intriguing solubility characteristics that can influence its applications in various fields.

  • Solvent Compatibility: This compound shows solubility in polar solvents, suggesting a tendency to interact favorably with compounds that have similar polarity. Common solvents include:
    • Water
    • Ethanol
    • Dimethyl sulfoxide (DMSO)
  • Non-Polar Solvents: In contrast, N-[4-(4-aminophenoxy)phenyl]acetamide is likely to have limited solubility in non-polar solvents. This can be attributed to its molecular structure, which contains significant functional groups that enhance hydrogen bonding and dipole interactions.
  • pH Sensitivity: The solubility may also be pH-dependent. Typically, solubility increases in more basic conditions due to ionization of the amine group, thereby enhancing water solubility.

**Key Takeaways:**

  • Polar solvents are preferred for dissolution
  • Limited solubility in non-polar solvents
  • Potential enhancement in solubility under basic conditions

In summary, understanding the solubility of N-[4-(4-aminophenoxy)phenyl]acetamide is vital for optimizing its usage in various chemical processes and formulations. As with many compounds, its solubility profile underlines the significance of solvent selection in achieving desired chemical behavior and efficacy.

Interesting facts

N-[4-(4-aminophenoxy)phenyl]acetamide: Interesting Facts

N-[4-(4-aminophenoxy)phenyl]acetamide is a fascinating compound that catches the attention of chemists and pharmaceutical researchers alike. This compound, often explored for its potential therapeutic properties, belongs to the class of amides, which play crucial roles in biological systems.

Structure and Characteristics

The structure of N-[4-(4-aminophenoxy)phenyl]acetamide can be intriguing due to the presence of both aromatic and amine functionalities. Some notable features include:

  • Aromatic Rings: The compound contains multiple phenyl groups, which contribute to its stability and reactivity.
  • Amine Functionality: The amine group enhances the solubility of this compound in biological systems, which is critical for its interaction with target molecules.
  • Acetamide Component: The acetyl group can influence the compound's biological activity, making it an important feature in drug design.

Biological Significance

This compound has garnered interest in the field of medicinal chemistry because of its potential applications:

  • Antimicrobial Activity: Preliminary studies suggest that compounds containing amino and acetamide groups may possess antimicrobial properties, making them candidates for further research.
  • Anticancer Research: Due to its structural similarities to known anticancer agents, it is being investigated for possible antitumor effects.
  • Analgesic Properties: Compounds with amine functionalities have been noted for their analgesic characteristics, indicating that this compound could provide pain relief.

Research and Future Directions

As research continues, the versatility of N-[4-(4-aminophenoxy)phenyl]acetamide may open up new avenues in drug development. Scientists are diligently exploring:

  • Multi-target Drug Design: Understanding how this compound interacts with multiple biological targets can lead to the design of more effective therapeutic agents.
  • Modification of Structure: Chemists are analyzing derivative compounds to enhance efficacy and reduce side effects.

Inspiration can be drawn from the field of organic chemistry, as "the best way to predict the future is to invent it," reflecting the diligent pursuit of knowledge surrounding compounds like N-[4-(4-aminophenoxy)phenyl]acetamide. As scientists continue to dissect its properties, the impact of this compound in medicinal applications remains a captivating area of exploration.

Synonyms
2687-41-4
N-[4-(4-aminophenoxy)phenyl]acetamide
N-(4-(4-Aminophenoxy)phenyl)acetamide
N-Acetyl-4,4'-diaminodiphenyl ether
4'-(p-Aminophenoxy)acetanilide
ACETANILIDE, 4'-(p-AMINOPHENOXY)-
Acetamide, N-(4-(4-aminophenoxy)phenyl)-
Acetamide, N-[4-(4-aminophenoxy)phenyl]-
NSC-74270
CCRIS 5689
NSC 74270
BRN 2126959
NSC74270
5NLW9TE5QK
SCHEMBL3547563
DTXSID80181381
BBL020832
MFCD01671299
STK893522
AKOS001476490
N-[4-(4-aminophenoxy)phenyl]-acetamide
BS-16756
4-ACETYLAMINO-4'-AMINODIPHENYL ETHER
CS-0153972
D83442