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N-[4-(4-aminophenyl)sulfonylphenyl]acetamide

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Identification
Molecular formula
C14H14N2O3S
CAS number
101-63-3
IUPAC name
N-[4-(4-aminophenyl)sulfonylphenyl]acetamide
State
State

At room temperature, N-[4-(4-aminophenyl)sulfonylphenyl]acetamide is a solid.

Melting point (Celsius)
275.00
Melting point (Kelvin)
548.15
Boiling point (Celsius)
496.00
Boiling point (Kelvin)
769.15
General information
Molecular weight
278.32g/mol
Molar mass
278.3220g/mol
Density
1.4123g/cm3
Appearence

The compound appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of N-[4-(4-aminophenyl)sulfonylphenyl]acetamide

N-[4-(4-aminophenyl)sulfonylphenyl]acetamide, often referred to as a sulfonamide derivative, exhibits intriguing solubility characteristics that are essential for its applications in various chemical and pharmaceutical sectors. The solubility of this compound can be influenced by several factors:

  • Polarity: Given the presence of both sulfonamide and amine groups, the compound tends to be polar, contributing to its solubility in polar solvents.
  • Hydrogen Bonding: The ability of the molecule to form hydrogen bonds enhances its solubility in water. This is particularly important for biological applications.
  • Temperature Effects: Like many organic compounds, solubility can increase with temperature. This is beneficial when trying to dissolve the compound in a laboratory setting.

As a general rule, compounds that contain functional groups capable of hydrogen bonding tend to have higher solubility in polar solvents such as water. According to common observations:

  • Compounds with strong hydrogen bond donors and acceptors are usually more soluble.
  • Solubility is often enhanced when dissolution occurs with solvent interactions that are energetically favorable.

In conclusion, while N-[4-(4-aminophenyl)sulfonylphenyl]acetamide demonstrates good solubility in aqueous solutions due to its polar characteristics and ability to engage in hydrogen bonding, specific solubility metrics will depend on experimental conditions. This property is essential, especially when considering drug design and delivery systems, as the solubility directly influences bioavailability and therapeutic efficacy.

Interesting facts

Interesting Facts about N-[4-(4-Aminophenyl)sulfonylphenyl]acetamide

N-[4-(4-aminophenyl)sulfonylphenyl]acetamide, commonly referred to as a sulfonamide derivative, is a fascinating compound that has gained attention in the field of medicinal chemistry.

Key Highlights:

  • Pharmacological Importance: This compound exhibits significant potential as an anti-inflammatory and analgesic agent, making it a candidate for various therapeutic applications.
  • Structural Features: The presence of both the sulfonyl group and the amine group contributes to its unique reactivity and biological activity, allowing for versatile interactions within biological systems.
  • Targeted Drug Design: Chemists exploit the compound's structure to develop targeted therapies, enhancing its efficacy while minimizing side effects.
  • Synthesis Techniques: It can be synthesized through multi-step organic reactions, showcasing the complexity and creativity involved in drug development.
  • Environmental Impact: As with many sulfonamide derivatives, understanding its behavior in the environment is crucial, especially regarding its potential to enter waterways and affect ecosystem health.

As we dive deeper into the world of this compound, we uncover not only its potential benefits as a therapeutic agent but also the challenges and ethical considerations associated with its use.

In summary, N-[4-(4-aminophenyl)sulfonylphenyl]acetamide stands as an exciting example of how chemistry continues to evolve in response to human health needs. The ongoing research into its properties and applications serves as a potent reminder of the critical role that chemical compounds play in our lives.

Synonyms
Monoacetyldapsone
565-20-8
N-Acetyldapsone
MADDS
Acetyldapsone
4'-Sulfanilylacetanilide
N-Acetyl-4,4'-diaminodiphenylsulfone
monoacetyl dapsone
N-(4-((4-Aminophenyl)sulfonyl)phenyl)acetamide
NSC 27184
CCRIS 5693
A4YKS8ULCN
monoacetyl-dapsone
ACETANILIDE, 4'-SULFANILYL-
N-Acetyl-4,4-diaminodiphenylsulfone
BRN 2746651
Acetamide, N-(4-((4-aminophenyl)sulfonyl)phenyl)-
NSC-27184
CHEBI:139473
DTXSID70205040
N-{4-[(4-aminophenyl)sulfonyl]phenyl}acetamide
3-13-00-01286 (Beilstein Handbook Reference)
Acetamide, N-[4-[(4-aminophenyl)sulfonyl]phenyl]-
N-acetyl-4,4'-diaminodiphenyl sulfone
N-[4-[(4-aminophenyl)sulfonyl]phenyl]acetamide
N-[4-(4-aminobenzene-1-sulfonyl)phenyl]acetamide
N-(4-[(4-Aminophenyl)sulfonyl]phenyl)acetamide
N-(4-(4-aminobenzene-1-sulfonyl)phenyl)acetamide
monoacetyl-diaminodiphenylsulfone
4-acetamido-phenyl-4'-aminophenyl sulfone
DTXCID70127531
Acetamide, N-(4-((4-aminophenyl)sulfonyl)phenyl)-(9CI)
621-642-3
N-Acetyl Dapsone
N-MONOACETYL-4,4'-DIAMINODIPHENYL SULFONE
N-[4-(4-aminophenyl)sulfonylphenyl]acetamide
N-Acetyldapsone;MADDS
4-(Acetamido)-4'-aminobiphenyl sulphone
MLS000090052
MFCD00672496
SMR000024670
UNII-A4YKS8ULCN
starbld0016694
Opera_ID_318
CHEMBL1246
MONO-N-ACETYL DAPSONE
p-Sulfanilylacetanilide Acetamide
SCHEMBL10920445
WDOCBIHNYYQINH-UHFFFAOYSA-N
HMS2230L14
HMS3371F07
HY-G0016
NSC27184
AKOS003272954
4-Acetylamino-4'-aminodiphenyl sulfone
AB06775
FA17014
NCGC00044286-02
N-[4-[(4-aminophenyl)sulfonyl]phenyl]-
TS-08842
DB-052929
Mono-N-acetyl-4-4 -sulfonylbisbenzeneamine
CS-0012514
NS00098468
N-[4-(4-aminobenzenesulfonyl)phenyl]acetamide
H43025
N-Acetyldapsone 100 microg/mL in Acetonitrile
Q27273637
N-[4-[(4-Aminophenyl)sulfonyl]phenyl]-acetamide;4-Acetamido-4'-aminodiphenyl sulphone;MADDS