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N-(4-Fluorophenyl)benzamide

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Identification
Molecular formula
C14H12FNO
CAS number
456-70-0
IUPAC name
N-[4-(4-fluorophenyl)phenyl]acetamide
State
State

At room temperature, N-(4-Fluorophenyl)benzamide exists in a solid state. It is typically stable under normal ambient and temperature conditions but should be handled with care to avoid exposure to high temperatures or reactive conditions.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
348.00
Boiling point (Kelvin)
621.15
General information
Molecular weight
229.25g/mol
Molar mass
229.2480g/mol
Density
1.2670g/cm3
Appearence

N-(4-Fluorophenyl)benzamide typically appears as a crystalline solid. Its color can range from white to off-white, depending on the purity of the sample.

Comment on solubility

Solubility of N-[4-(4-fluorophenyl)phenyl]acetamide

N-[4-(4-fluorophenyl)phenyl]acetamide, a compound with the formula C15H14FNO, exhibits specific solubility characteristics that are crucial for its applications in various fields.

Solubility Overview: This compound is generally more soluble in organic solvents compared to water, owing to its hydrophobic aromatic structure. The solubility is often influenced by several factors:

  • Polarity: The presence of a fluorine atom enhances the electron-withdrawing nature of the molecule, which can affect its interaction with solvents.
  • Temperature: Increased temperatures typically enhance solubility, allowing the compound to dissolve more readily in suitable organic media.
  • Solvent Choice: It shows significant solubility in solvents like dichloromethane, ethanol, and dimethyl sulfoxide (DMSO).

In general, while ionic compounds tend to be soluble in polar solvents, this particular compound's non-polar characteristics suggest a limited solubility in water. Therefore, it is often best to employ organic solvents to achieve effective dissolution.

To summarize, understanding the solubility profile of N-[4-(4-fluorophenyl)phenyl]acetamide is vital for its practical applications, especially in formulations where solvent compatibility is key.

Interesting facts

Interesting Facts about N-[4-(4-fluorophenyl)phenyl]acetamide

N-[4-(4-fluorophenyl)phenyl]acetamide is an intriguing chemical compound that plays a significant role in medicinal chemistry and pharmaceutical development. Here are some fascinating aspects of this compound:

  • Pharmaceutical Potential: This compound has been studied for its potential use as an analgesic and anti-inflammatory agent. Its structure suggests that it may interact with specific biological pathways, offering therapeutic applications.
  • Structure Insights: The presence of a fluorine atom is particularly noteworthy. Fluorine substitution can enhance the metabolic stability of the compound, potentially leading to improved pharmacokinetics.
  • Research Applications: Researchers often explore such compounds to understand structure–activity relationships (SAR). By modifying either the acetamide or the phenyl rings, scientists can investigate how these changes affect biological activity.
  • Intermolecular Forces: The molecular design allows for various types of intermolecular interactions, including hydrogen bonds and π-π stacking, which can influence the compound’s efficacy as a drug.
  • Analytical Techniques: Advanced analytical methods, such as NMR and mass spectrometry, are commonly employed to characterize and confirm the structure of N-[4-(4-fluorophenyl)phenyl]acetamide, providing valuable insights into its properties.

Overall, N-[4-(4-fluorophenyl)phenyl]acetamide represents a compelling area of study, reflecting the intricate interplay between chemical structure and biological activity. As scientists continue to explore this compound, its unique characteristics could pave the way for novel therapeutic strategies.

Synonyms
398-32-3
4'-(p-Fluorophenyl)acetanilide
4'-(4-fluorophenyl)acetanilide
N-[4-(4-fluorophenyl)phenyl]acetamide
N-4-(4'-Fluorobiphenyl)acetamide
4'-Fluoro-4-biphenylacetamide
N-(4'-Fluoro-4-biphenylyl)acetamide
N-4-(4'-Fluoro)biphenylacetamide
4'-Fluoro-4-acetylaminobiphenyl
Acetamide, N-(4'-fluoro-4-biphenylyl)-
ACETANILIDE, 4'-(p-FLUOROPHENYL)-
EINECS 206-912-7
NSC 73090
BRN 2806508
S59S53MB7A
Acetamide, N-(4'-fluoro(1,1'-biphenyl)-4-yl)-
N-(4'-Fluoro(1,1'-biphenyl)-4-yl)acetamide
NSC-73090
4-acetylamino-4'-fluorobiphenyl
DTXSID2020632
N-(4'-fluoro[1,1'-biphenyl]-4-yl)acetamide
CHEBI:189411
4-12-00-03268 (Beilstein Handbook Reference)
N-(4'-fluoro-4-biphenyl)acetamide
4-ACETAMIDO-4'-FLUOROBIPHENYL
N-(4'-fluoro[biphenyl]-4-yl)acetamide
FLUOROBIPHENYL)ACETAMIDE, N-4-(4'-
N-{4'-FLUORO-[1,1'-BIPHENYL]-4-YL}ACETAMIDE
N-(4-(4-fluorophenyl)phenyl)acetamide
N-(4'-fluoro(biphenyl)-4-yl)acetamide
N-(4'-fluoro-(1,1'-biphenyl)-4-yl)acetamide
FBPA
N-(4'-fluorobiphenyl-4-yl)acetamide
WLN: FR DR DMV1
NCIOpen2_003838
UNII-S59S53MB7A
DTXCID80632
SCHEMBL24878628
JORMZLCKCZMVJM-UHFFFAOYSA-N
4'-Fluoro-4-(acetylamino)biphenyl
ALBB-036855
NSC73090
AKOS024306971
DB-049488
NS00042722
Q63088211
Acetamide, N-(4'-fluoro(1,1'-biphenyl)-4-yl)-(9CI)