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Meloxicam

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Identification
Molecular formula
C14H13N3O3
CAS number
71125-38-7
IUPAC name
N-[4-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methyleneamino]phenyl]acetamide
State
State

At room temperature, meloxicam is in a solid state. It is often found in powder form and is utilized primarily in oral tablet formulations in medical applications.

Melting point (Celsius)
255.00
Melting point (Kelvin)
528.15
Boiling point (Celsius)
545.10
Boiling point (Kelvin)
818.30
General information
Molecular weight
351.41g/mol
Molar mass
351.4090g/mol
Density
1.4000g/cm3
Appearence

Meloxicam appears as a light yellow crystalline powder, which is practically insoluble in water. Due to its distinctive structure, meloxicam can sometimes appear pale green as well. It is often used in pharmaceutical formulations.

Comment on solubility

Solubility of N-[4-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methyleneamino]phenyl]acetamide

The solubility of N-[4-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methyleneamino]phenyl]acetamide in various solvents is an important characteristic that can influence its applications in chemical processes and pharmaceutical formulations.

This compound exhibits a few notable solubility properties:

  • Polar Solvents: N-[4-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methyleneamino]phenyl]acetamide tends to be soluble in polar solvents like water, which enhances its utility in biological systems.
  • Non-Polar Solvents: The solubility in non-polar solvents may be limited due to the presence of polar functional groups, making it less effective for applications requiring non-polar environments.
  • Temperature Dependence: As with many organic compounds, solubility can vary significantly with temperature; typically, increased temperature may lead to higher solubility in the appropriate solvents.

It's worth noting that understanding the solubility profile of this compound is crucial for its effective use in various applications. As the saying goes, "like dissolves like," meaning that the nature of the solvent plays a pivotal role in the ability of the compound to dissolve. Therefore, various experiments under controlled conditions are recommended to ascertain the exact solubility limits.

Interesting facts

Interesting Facts about N-[4-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methyleneamino]phenyl]acetamide

N-[4-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methyleneamino]phenyl]acetamide is a fascinating compound worth exploring due to its unique structural and functional characteristics. Here are some intriguing points about this compound:

  • Versatility: This compound showcases the versatility of pyrazole-based derivatives, which are known for their wide range of biological activities.
  • Pharmacological Potential: Compounds similar to N-[4-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methyleneamino]phenyl]acetamide often exhibit anti-inflammatory and analgesic properties, making them a subject of interest in medicinal chemistry.
  • Structure-Activity Relationship: The interplay between the acetyl group and the pyrazole ring highlights essential relationships in drug design. Understanding how different substitutions can influence activity opens avenues for further research.
  • Research Significance: Scientific studies often leverage the inherent structural complexity of this compound to synthesize new derivatives, which could lead to the development of novel therapeutic agents.
  • Potential Applications: Beyond pharmaceutical applications, compounds like these can also find utility in agrochemicals and the synthesis of functional materials due to their reactive functional groups.

In summary, N-[4-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methyleneamino]phenyl]acetamide serves as a remarkable example of how intricate structural designs can lead to significant advancements in various fields of chemistry. As stated by researchers, “The quest for new and effective compounds is a perpetual journey in medicinal chemistry.” This molecule certainly contributes to that journey.

Synonyms
24664-51-5
N-(4-(((3-Methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)methyl)amino)phenyl)acetamide
BRN 0834839
4-(p-Acetamidoanilinomethylene)-3-methyl-1-phenyl-2-pyrazolin-5-one
4'-((3-Methyl-5-oxo-1-phenyl-2-pyrazolin-4-ylidene)methylamino)acetanilide
ACETANILIDE, 4'-((3-METHYL-5-OXO-1-PHENYL-2-PYRAZOLIN-4-YLIDENE)METHYLAMINO)-
5-25-14-00509 (Beilstein Handbook Reference)
STK852294
AKOS001094965
AKOS024363991
AKOS030752042
4'-[[(3-Methyl-5-oxo-1-phenyl-2-pyrazolin-4-ylidene)methyl]amino]acetanilide
ST50995694
AB00090957-01
SR-01000215055
SR-01000215055-1
Z57985148
N-(4-{[(3-methyl-5-oxo-1-phenyl-1,2-diazolin-4-ylidene)methyl]amino}phenyl)ace tamide
N-[4-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylideneamino]phenyl]acetamide
N-(4-{[(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)methyl]amino}phenyl)acetamide
N-(4-{[(E)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)methyl]amino}phenyl)acetamide