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Lisinopril

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Identification
Molecular formula
C21H31N3O5
CAS number
76547-98-3
IUPAC name
N-[4-(6-benzyl-3-isopropyl-2,5,8,11-tetraoxo-1,4,7,10-tetrazabicyclo[10.3.0]pentadecan-9-yl)butyl]acetamide
State
State

Lisinopril is typically a solid at room temperature.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.00
Boiling point (Celsius)
301.00
Boiling point (Kelvin)
574.00
General information
Molecular weight
405.50g/mol
Molar mass
405.4950g/mol
Density
1.2300g/cm3
Appearence

Lisinopril appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of N-[4-(6-benzyl-3-isopropyl-2,5,8,11-tetraoxo-1,4,7,10-tetrazabicyclo[10.3.0]pentadecan-9-yl)butyl]acetamide

The solubility of N-[4-(6-benzyl-3-isopropyl-2,5,8,11-tetraoxo-1,4,7,10-tetrazabicyclo[10.3.0]pentadecan-9-yl)butyl]acetamide (C21H31N3O5) in various solvents can be somewhat complex due to its intricate structure and functional groups. Here are some key points regarding its solubility:

  • Polar Solvents: Compounds with polar functional groups generally exhibit better solubility in polar solvents such as water and alcohols.
  • Nonpolar Solvents: The presence of hydrophobic regions indicates potential solubility in nonpolar solvents like hexane or toluene.
  • Temperature Influence: Increased temperature can enhance solubility by disrupting intermolecular forces.
  • pH Dependence: The solubility may also vary with pH due to the presence of amine functionalities that can be protonated.

In experimental settings, the compound's solubility might be explored through various techniques, such as:

  1. Measuring solubility at defined temperature conditions.
  2. Conducting solubility tests in multiple solvents to ascertain a broader solubility profile.
  3. Utilizing techniques like UV-Vis spectroscopy for quantitative analysis.

Thus, understanding the solubility characteristics of this compound is crucial for its practical applications, and researchers should conduct thorough assessments based on the conditions of interest.

Interesting facts

Interesting Facts about N-[4-(6-benzyl-3-isopropyl-2,5,8,11-tetraoxo-1,4,7,10-tetrazabicyclo[10.3.0]pentadecan-9-yl)butyl]acetamide

N-[4-(6-benzyl-3-isopropyl-2,5,8,11-tetraoxo-1,4,7,10-tetrazabicyclo[10.3.0]pentadecan-9-yl)butyl]acetamide, a compound with a remarkably complex structure, piques the interest of chemists for several reasons:

  • Structural Diversity: The compound features an intricate bicyclic structure, which is a hallmark of many biologically active molecules. This structural diversity contributes to its potential for novel interactions in biochemical systems.
  • Pharmacological Potential: Compounds containing a tetrazole moiety, like this one, have garnered attention in medicinal chemistry due to their unique biological activities, often serving as pharmacophores in drug design.
  • Synthetic Challenges: The synthesis of such complex molecules can be labor-intensive and challenging. This leads to significant research in synthetic methodologies that can efficiently construct similar compounds in the laboratory.
  • Applications: Due to its unique features, this compound may find applications in various fields such as pharmaceuticals, materials science, and agricultural chemistry. Understanding its properties could pave the way for innovative developments.

In the words of the famous chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This sentiment rings true in the study of complex molecules like N-[4-(6-benzyl-3-isopropyl-2,5,8,11-tetraoxo-1,4,7,10-tetrazabicyclo[10.3.0]pentadecan-9-yl)butyl]acetamide, reminding us that the exploration of such compounds can lead to groundbreaking discoveries in chemistry and beyond.