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Acetaminophen trifluoroacetate

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Identification
Molecular formula
C10H8F3NO2
CAS number
93921-35-4
IUPAC name
N-(4-acetylphenyl)-2,2,2-trifluoro-acetamide
State
State

At room temperature, N-(4-acetylphenyl)-2,2,2-trifluoro-acetamide is a solid. Due to its crystalline nature, it is stable under standard conditions.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
295.30
Boiling point (Kelvin)
568.50
General information
Molecular weight
247.21g/mol
Molar mass
247.2050g/mol
Density
1.3530g/cm3
Appearence

N-(4-acetylphenyl)-2,2,2-trifluoro-acetamide is typically a white crystalline solid. It is often odorless and shares a similar structural appearance to related amides with aromatic rings.

Comment on solubility

Solubility of N-(4-acetylphenyl)-2,2,2-trifluoro-acetamide

N-(4-acetylphenyl)-2,2,2-trifluoro-acetamide presents interesting characteristics concerning its solubility. Generally, the solubility of this compound can be influenced by several factors:

  • Polarity: The presence of the trifluoroacetyl group introduces significant polarity.
  • Hydrogen Bonding: This compound can engage in hydrogen bonding due to the amide functional group, enhancing interactions with polar solvents.
  • Solvent Interactions: Its moderate solubility is often seen in solvents like methanol and acetone.
  • Temperature Effects: Higher temperatures can typically increase solubility as molecular movement allows for better interactions between solute and solvent.

In summary, while N-(4-acetylphenyl)-2,2,2-trifluoro-acetamide is more soluble in polar solvents, its behavior can vary based on the conditions under which it is dissolved. As always, one should consider the specific solvent environment for accurate predictions of solubility.

Interesting facts

Interesting Facts about N-(4-Acetylphenyl)-2,2,2-Trifluoro-acetamide

N-(4-acetylphenyl)-2,2,2-trifluoro-acetamide is a fascinating compound with a variety of intriguing properties and applications. Here are some interesting facts about this compound:

  • Fluorinated Structure: The incorporation of trifluoroacetyl groups not only enhances the lipophilicity of the compound but also markedly alters its reactivity and stability compared to non-fluorinated analogs.
  • Pharmaceutical Applications: Compounds like N-(4-acetylphenyl)-2,2,2-trifluoro-acetamide are significant in the pharmaceutical industry. They may serve as intermediates or active pharmaceutical ingredients (APIs) owing to their potential biological activities.
  • Potential Biological Activities: Research has suggested that certain derivatives of this compound could exhibit anti-inflammatory or analgesic properties, making them a subject of interest for drug discovery.
  • Reactivity: The trifluoroacetyl moiety can participate in various chemical reactions, leading to the formation of other complex molecules. This makes it a useful building block in synthetic organic chemistry.
  • Importance in Material Science: Due to its unique electronic properties, this compound could be leveraged in the development of advanced materials, including polymeric substances with tailored characteristics.

In summary, N-(4-acetylphenyl)-2,2,2-trifluoro-acetamide is not just a compound of interest due to its structure but also for the diverse applications it supports across various fields including pharmaceuticals, materials science, and organic chemistry. Scientists continue to explore the depths of its potential, making it a compound worth significant attention.

Synonyms
N-(4-acetylphenyl)-2,2,2-trifluoroacetamide
24568-13-6
ACETANILIDE, 4'-ACETYL-2,2,2-TRIFLUORO-
DTXSID80179304
RefChem:1091232
DTXCID70101795
Acetamide, N-(4-acetylphenyl)-2,2,2-trifluoro-
4'-Acetyl-2,2,2-trifluoroacetanilide
MFCD00780957
N-(4-Acetyl-phenyl)-2,2,2-trifluoro-acetamide
NSC 103788
BRN 2374913
NSC103788
SCHEMBL7428266
SCHEMBL7428282
IILMTVMHMUEWFW-UHFFFAOYSA-N
ALBB-002858
STK013557
AKOS000485395
NSC-103788
LS-01221
ST005600
CS-0309344
EN300-176793
G32159
N-(4-acetylphenyl)-2,2,2-trifluoro-acetamide
AG-219/36619010
BRD-K67849647-001-01-2
Z56968128