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N-(4-aminophenyl)sulfonyl-N-(3,4-dimethylisoxazol-5-yl)acetamide

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Identification
Molecular formula
C13H15N3O4S
CAS number
180543-02-8
IUPAC name
N-(4-aminophenyl)sulfonyl-N-(3,4-dimethylisoxazol-5-yl)acetamide
State
State

At room temperature, N-(4-aminophenyl)sulfonyl-N-(3,4-dimethylisoxazol-5-yl)acetamide is typically a solid.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
363.15
Boiling point (Kelvin)
636.15
General information
Molecular weight
307.34g/mol
Molar mass
307.3400g/mol
Density
1.3650g/cm3
Appearence

This compound is a solid at room temperature. It appears generally as a crystalline powder which can range in color from off-white to light yellow depending on the degree of purity and potential impurities.

Comment on solubility

Solubility of N-(4-aminophenyl)sulfonyl-N-(3,4-dimethylisoxazol-5-yl)acetamide

The solubility of N-(4-aminophenyl)sulfonyl-N-(3,4-dimethylisoxazol-5-yl)acetamide presents interesting characteristics that are essential for its application in various chemical and pharmaceutical contexts.

Here are some insights regarding its solubility:

  • Polarity: The compound contains both polar and nonpolar functional groups, leading to a complex solubility profile. The sulfonamide group can interact favorably with polar solvents.
  • Solvent Dependency: This compound is generally more soluble in polar solvents such as water and methanol compared to nonpolar solvents, due to its ability to form hydrogen bonds.
  • pH Influence: The solubility is often influenced by pH; acidic environments tend to enhance solubility through protonation of amino groups.

As a rule of thumb, one may find that:

  1. Higher temperature generally increases solubility for solids like this compound.
  2. The presence of co-solvents can significantly affect solubility, often used to optimize conditions for pharmaceutical formulations.

In summary, the solubility properties of N-(4-aminophenyl)sulfonyl-N-(3,4-dimethylisoxazol-5-yl)acetamide are dictated by its molecular structure and external conditions, and understanding these factors is crucial when considering its practical applications.

Interesting facts

Interesting Facts about N-(4-aminophenyl)sulfonyl-N-(3,4-dimethylisoxazol-5-yl)acetamide

N-(4-aminophenyl)sulfonyl-N-(3,4-dimethylisoxazol-5-yl)acetamide, often referred to in the scientific community by its structural components, is a compound that has garnered interest for its potential applications in medicinal chemistry. With its unique structure, this compound is thought to play a significant role in the development of pharmaceuticals, particularly in the area of anti-inflammatory medications.

Key Characteristics

  • Pharmacological Potential: The isoxazole moiety is known for its diverse biological properties, making this compound a candidate for research into new therapeutic agents.
  • Functional Groups: The presence of sulfonamide and amine functional groups enhances its interaction with biological targets, providing insight into its mechanism of action in various biochemical pathways.
  • Applications: Research indicates potential applications in treating conditions such as pain and inflammation, potentially leading to innovative treatment options.

This compound exemplifies the complexity and beauty of organic synthesis, showcasing how different functional groups can be combined to create molecules with significant health benefits. As emphasized by researchers, "The design of such compounds is crucial in the quest for effective and safer therapeutic agents." It is a vivid reminder of how the world of chemistry continuously evolves, paving the way for cures and advancements in healthcare.

Research and Development

Ongoing research into N-(4-aminophenyl)sulfonyl-N-(3,4-dimethylisoxazol-5-yl)acetamide is crucial for:

  • Understanding its mechanism of action.
  • Identifying potential side effects and interactions with other drugs.
  • Exploring its efficacy in clinical settings.

Ultimately, compounds like this one illustrate the intersection of chemistry, biology, and medicine, demonstrating how a single chemical structure can have far-reaching implications for human health.

Synonyms
Sulfisoxazole acetyl
80-74-0
ACETYL SULFISOXAZOLE
Lipo Gantrisin
acetylsulfafurazole
N-((4-Aminophenyl)sulfonyl)-N-(3,4-dimethylisoxazol-5-yl)acetamide
Acetylsulfisoxazole
GANTRISIN PEDIATRIC
Acetyl sulfafurazole
Sulfafurazole acetyl
Sulfisoxazole acetal
Sulfisoxizole acetyl
Acetylgantrisin
UNII-WBT5QH3KED
WBT5QH3KED
N-(3,4-Dimethyl-5-isoxazolyl)-N-sulfanilylacetamide
EINECS 201-305-3
N-(4-aminophenyl)sulfonyl-N-(3,4-dimethyl-1,2-oxazol-5-yl)acetamide
NSC-759138
Sulfisoxazole acetyl (USP)
Sulfisoxazole acetyl [USP]
DTXSID4023620
Acetamide, N-((4-aminophenyl)sulfonyl)-N-(3,4-dimethyl-5-isoxazolyl)-
NSC 759138
ERYZOLE COMPONENT SULFISOXAZOLE ACETYL
Acetylsulfisoxazole (JAN)
PEDIAZOLE COMPONENT SULFISOXAZOLE ACETYL
ILOSONE SULFA COMPONENT SULFISOXAZOLE ACETYL
ACETYLSULFISOXAZOLE [JAN]
ACETYL SULFAFURAZOLE (MART.)
ACETYL SULFAFURAZOLE [MART.]
N-[(4-Aminophenyl)sulfonyl]-N-(3,4-dimethyl-5-isoxazolyl)acetamide
SULFISOXAZOLE ACETYL (USP-RS)
SULFISOXAZOLE ACETYL [USP-RS]
Acetamide, N-[(4-aminophenyl)sulfonyl]-N-(3,4-dimethyl-5-isoxazolyl)-
SULFISOXAZOLE ACETYL (USP MONOGRAPH)
SULFISOXAZOLE ACETYL [USP MONOGRAPH]
N-[(4-aminophenyl)sulfonyl]-N-(3,4-dimethylisoxazol-5-yl)acetamide
sulfisoxazole-acetyl
N-3,4-Dimethylisoxazol-5-yl-N-sulphanilylacetamide
MFCD00072139
Lipo gantrisin (TN)
SCHEMBL41727
DTXCID103620
CHEMBL1200910
ACETYL SULFISOXAZOLE [MI]
N-3,4-DIMETHYLISOXAZOL-5-YL-N-SULFANILYLACETAMIDE
CHEBI:135975
AAA08074
N-(4-aminophenyl)sulfonyl-N-(3,4-dimethylisoxazol-5-yl)acetamide
SULFISOXAZOLE ACETYL [VANDF]
Tox21_113660
SULFAFURAZOLE ACETYL [WHO-DD]
AKOS027427029
DB14033
CAS-80-74-0
NCGC00249884-01
SULFISOXAZOLE ACETYL [ORANGE BOOK]
TS-08127
HY-107923
CS-0030871
NS00011876
A10807
D05956
SULFISOXAZOLE ACETYL COMPONENT OF ERYZOLE
EN300-18539450
SULFISOXAZOLE ACETYL COMPONENT OF PEDIAZOLE
BRD-K84810336-001-01-9
Q27292550
SULFISOXAZOLE ACETYL COMPONENT OF ILOSONE SULFA
Acetamide, N-(3,4-dimethyl-5-isoxazolyl)-N-sulfanilyl-
N-Acetyl-4-amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide #
N-(4-aminobenzenesulfonyl)-N-(3,4-dimethyl-1,2-oxazol-5-yl)acetamide
N-[(4-aminophenyl)sulfonyl]-N-(3,4-dimethyl-5- isoxazolyl)acetamide
201-305-3