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N-(4-aminophenyl)sulfonylbenzamide

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Identification
Molecular formula
C13H12N2O3S
CAS number
.CAS not known
IUPAC name
N-(4-aminophenyl)sulfonylbenzamide
State
State

At room temperature, it is in a solid state.

Melting point (Celsius)
227.00
Melting point (Kelvin)
500.15
Boiling point (Celsius)
543.00
Boiling point (Kelvin)
816.15
General information
Molecular weight
278.31g/mol
Molar mass
278.3100g/mol
Density
1.4347g/cm3
Appearence

This compound typically appears as a white to off-white crystalline solid.

Comment on solubility

Solubility of N-(4-aminophenyl)sulfonylbenzamide

The solubility of N-(4-aminophenyl)sulfonylbenzamide (C13H12N2O3S) can be influenced by several factors, leading to interesting characteristics:

  • Polar vs Non-Polar Solvents: N-(4-aminophenyl)sulfonylbenzamide is more likely to be soluble in polar solvents compared to non-polar ones, primarily due to the presence of sulfonamide and amine functional groups.
  • Temperature Dependency: As with many organic compounds, an increase in temperature can enhance the solubility of N-(4-aminophenyl)sulfonylbenzamide, as higher temperatures typically allow more solute to dissolve in a solvent.
  • pH Influence: The solubility may also vary with pH. The ionizable groups in the compound can affect how well it dissolves depending on the acidity or basicity of the solution.
  • Crystallization: N-(4-aminophenyl)sulfonylbenzamide has a tendency to crystallize, which can lead to variations in solubility depending on the crystalline form produced.
  • Applications: Understanding its solubility properties is crucial in fields such as pharmaceuticals, where effective dissolution can impact drug delivery and bioavailability.

Overall, the solubility profile of N-(4-aminophenyl)sulfonylbenzamide underscores the importance of molecular structure in determining how compounds interact with their environment. As noted, its solubility is influenced by a combination of factors, making it essential to consider these attributes in practical applications.

Interesting facts

Exploring N-(4-Aminophenyl)sulfonylbenzamide

N-(4-aminophenyl)sulfonylbenzamide is a fascinating chemical compound that has garnered interest in various fields, particularly in pharmaceuticals. Here are some compelling facts about this compound:

  • Pharmacological Potential: This compound is often studied for its potential therapeutic properties, especially in the treatment of diseases where sulfonamide moieties have shown activity, such as antibacterial and antitubercular effects.
  • Structural Features: The structure of N-(4-aminophenyl)sulfonylbenzamide features a sulfonamide group, which is known for its ability to disrupt bacterial folate synthesis, making it a significant point of interest in drug design.
  • Research Applications: This compound is often used as a scaffold in medicinal chemistry to develop new drugs that can combat various pathogenic organisms or target specific biological pathways.
  • Interdisciplinary Connections: The study of N-(4-aminophenyl)sulfonylbenzamide touches upon multiple scientific disciplines, including organic chemistry, medicinal chemistry, and pharmacology.
  • Importance of Amino Groups: The amino group (-NH2) present in the compound plays a crucial role in its reactivity and biological activity, influencing how it interacts with biological targets.

As a scientist or a chemistry student, one might appreciate how such compounds often serve as building blocks in the synthesis of more complex molecules. The exploration of N-(4-aminophenyl)sulfonylbenzamide not only unveils the intricacies of chemical interactions but also highlights the relationship between structure and function in drug development.

In conclusion, this compound is a prime example of how a simple modification in molecular structure can lead to significant differences in biological activity, making it a valuable compound in the quest for new therapeutic agents.

Synonyms
sulfabenzamide
127-71-9
N-Sulfanilylbenzamide
Sulfabenzide
Sulfabenzoylamide
Sulfabenzid
N-(4-aminophenyl)sulfonylbenzamide
Sulfabenzamida
Benzamide, N-[(4-aminophenyl)sulfonyl]-
N-Benzoylsulfanilamide
Sulfabenzamid
Sulfabenzamidum
N-Sulfamylbenzamide
Sulfamylbenzamide
N-(4-Aminobenzenesulfonyl)benzamide
N-((4-Aminophenyl)sulfonyl)benzamide
N-[(4-Aminophenyl)sulfonyl]benzamide
N-(p-Aminobenzenesulfonyl)benzamide
Benzamide, N-sulfanilyl-
Benzamide, N-((4-aminophenyl)sulfonyl)-
N(sup1)-Benzoylsulfanilamide
Sulfanilamide, N(sup1)-benzoyl-
G58F8OPL4I
NSC 74587
NSC-74587
Triple sulfa (sulfabenzamide)
DTXSID7045287
MFCD00044890
N(1)-benzoylsulfanilamide
SULFABENZAMIDE [MI]
BENZOYL SULFANILAMIDE
SULFABENZAMIDE [INN]
SULFABENZAMIDE [USAN]
SULFABENZAMIDE [VANDF]
MLS000069716
SULFABENZAMIDE [MART.]
SULFABENZAMIDE [USP-RS]
SULFABENZAMIDE [WHO-DD]
DTXCID5025287
CHEBI:94677
N-(4-aminophenylsulfonyl)benzamide
NSC74587
SULFABENZAMIDE [ORANGE BOOK]
SULFABENZAMIDE (TRIPLE SULFA)
SULFABENZAMIDE [USP IMPURITY]
TRYSUL COMPONENT SULFABENZAMIDE
SULTRIN COMPONENT SULFABENZAMIDE
VAGILIA COMPONENT SULFABENZAMIDE
N-(4-aminobenzene-1-sulfonyl)benzamide
NCGC00016385-01
CAS-127-71-9
GYNE-SULF COMPONENT SULFABENZAMIDE
SMR000058257
TRIPLE SULFA (SULFABENZAMIDE) [ORANGE BOOK]
SULFABENZAMIDE (MART.)
SULFABENZAMIDE (USP-RS)
SULFABENZAMIDE (USP IMPURITY)
Sulfabenzamidum [INN-Latin]
Sulfabenzamida [INN-Spanish]
N(sup 1)-Benzoylsulfanilamide
N1-Benzoylsulfanilamide
Sulfanilamide, N(sup 1)-benzoyl-
SR-01000000178
EINECS 204-859-4
UNII-G58F8OPL4I
BRN 2139003
AI3-08024
Prestwick_1019
Sulfabenzamide [USAN:USP:INN:BAN]
Spectrum_000982
Opera_ID_1271
Prestwick0_000711
Prestwick1_000711
Prestwick2_000711
Prestwick3_000711
Spectrum2_001317
Spectrum3_000569
Spectrum4_000341
Spectrum5_001066
Sulfabenzamide (Standard)
Sulfabenzamide (USP/INN)
Sulfanilamide, N1-benzoyl-
CHEMBL1243
SCHEMBL93841
BSPBio_000921
BSPBio_001958
KBioGR_000741
KBioSS_001462
4-14-00-02664 (Beilstein Handbook Reference)
DivK1c_000537
SPECTRUM1500544
SPBio_001413
SPBio_002842
BPBio1_001015
GTPL12632
HMS501K19
HY-B0960R
KBio1_000537
KBio2_001462
KBio2_004030
KBio2_006598
KBio3_001458
N-benzoyl4-aminobenzenesulfonamide
NINDS_000537
HMS1570O03
HMS1921A09
HMS2092I11
HMS2097O03
HMS2234F05
HMS3372C11
HMS3714O03
Pharmakon1600-01500544
4-Amino-N-benzoylbenzenesulfonamide
N-benzoyl-4-aminobenzenesulfonamide
HY-B0960
Tox21_110410
CCG-39255
NSC757322
s4576
STK985629
4-Amino-N-benzoylbenzenesulfonamide #
AKOS000482643
Tox21_110410_1
BS-4997
CS-4442
DB09355
FS27929
N-[(4-aminophenyl)sulfonyl]-benzamide
NSC-757322
IDI1_000537
NCGC00016385-02
NCGC00016385-03
NCGC00016385-04
NCGC00016385-05
NCGC00016385-06
NCGC00016385-08
NCGC00022347-03
NCGC00022347-04
SULFABENZAMIDE COMPONENT OF TRYSUL
AC-24189
SULFABENZAMIDE COMPONENT OF SULTRIN
SULFABENZAMIDE COMPONENT OF VAGILIA
SBI-0051518.P003
DB-041871
AB00052093
NS00008182
S0582
SULFABENZAMIDE COMPONENT OF GYNE-SULF
C72147
D05946
AB00052093_15
EN300-7411279
4-amino-N-(1-phenyl-methanoyl)-benzenesulfonamide
Sulfabenzamide, VETRANAL(TM), analytical standard
Q7636176
SR-01000000178-2
SR-01000000178-3
BRD-K59983611-001-05-2
BRD-K59983611-001-15-1
BRD-K59983611-001-21-9
204-859-4
BS4
N-[(4-Aminophenyl)sulfonyl]-benzamide;N-(Benzoyl)-4-aminobenzenesulfonamide;N1-Benzoylsulfanilamide