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Propofol

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Identification
Molecular formula
C12H18O
CAS number
2078-54-8
IUPAC name
N-(4-benzyloxy-2,6-dimethyl-phenyl)-2-(dipropylamino)acetamide
State
State

At room temperature, propofol is in a liquid state. However, when formulated for clinical use, it is presented as an emulsion for intravenous administration.

Melting point (Celsius)
18.00
Melting point (Kelvin)
291.15
Boiling point (Celsius)
256.00
Boiling point (Kelvin)
529.15
General information
Molecular weight
178.27g/mol
Molar mass
178.2710g/mol
Density
1.0234g/cm3
Appearence

Propofol is typically a white, milky emulsion when prepared for medical use, appearing as a sterile, non-pyrogenic oil-in-water emulsion suitable for intravenous injection. In its pure form, it exists as a colorless, slightly yellowish liquid.

Comment on solubility

Solubility of N-(4-benzyloxy-2,6-dimethyl-phenyl)-2-(dipropylamino)acetamide

N-(4-benzyloxy-2,6-dimethyl-phenyl)-2-(dipropylamino)acetamide, with its complex structure, exhibits specific solubility characteristics that are essential for its functionality in various applications. The solubility of this compound can be influenced by several factors:

  • Polarity: The presence of both hydrophobic (benzyloxy and dipropyl) and hydrophilic (acetamide) portions may lead to intermediate solubility in water.
  • Solvent Interaction: This compound may dissolve better in organic solvents such as ethanol or dimethyl sulfoxide (DMSO) than in aqueous solutions due to its larger non-polar components.
  • Temperature Dependence: Generally, an increase in temperature can enhance the solubility of organic compounds, making this an important factor to consider when preparing solutions.
  • pH Influence: The ionization state of the acetamide group can vary with pH, potentially affecting solubility, especially in polar solvents.

In summary, while N-(4-benzyloxy-2,6-dimethyl-phenyl)-2-(dipropylamino)acetamide's solubility can be moderately variable, its behavior in different solvents can help in understanding its practical applications. Thus, it's essential to carry out solubility tests under specific conditions to determine its solvent compatibility effectively.

Interesting facts

Interesting Facts About N-(4-benzyloxy-2,6-dimethyl-phenyl)-2-(dipropylamino)acetamide

This compound belongs to a fascinating class of chemicals known as amide derivatives. Amides are particularly interesting for chemists due to their unique properties and applications in various fields.

Key Features

  • Biological Activity: Compounds like this one often exhibit significant biological activity, making them of value in pharmaceutical research. They can be potential candidates for drug development, particularly in areas targeting neurodegenerative diseases.
  • Synthetic Pathways: The synthesis of this compound may involve complex organic reactions, including amination and acylation processes. Studying these pathways can provide insights into effective methods for creating amides.
  • Functional Groups: The presence of both the dipropylamino group and the benzyloxy group suggests potential interactions with biological receptors, as these functional groups can influence solubility and reactivity.

Applications

This compound's structure hints at interesting applications:

  • Potential use in drug formulation due to its amide structure, which can enhance biological stability.
  • Investigative studies in medicinal chemistry to explore its effects on biological systems.

Educational Significance

For chemistry students, this compound serves as an excellent example of how organic chemistry can translate into real-world applications. Understanding such compounds can enrich their knowledge of:

  • Organic synthesis techniques and strategies.
  • The importance of functional group interactions in chemical reactivity.
  • The process of drug discovery and development.

As a closing note, it’s imperative to remember that the world of chemistry produces compounds that are not only a joy to study but also hold the promise of substantial human benefit. Each compound, including N-(4-benzyloxy-2,6-dimethyl-phenyl)-2-(dipropylamino)acetamide, contributes new knowledge to the vast tapestry of science.

Synonyms
A 1215
17060-69-4
ACETAMIDE, N-(2,6-DIMETHYL-4-(PHENYLMETHOXY)PHENYL)-2-(DIPROPYLAMINO)-
4'-(Benzyloxy)-2-(dipropylamino)-2',6'-acetoxylidide
DTXSID10168903
N-(2,6-Dimethyl-4-(phenylmethoxy)phenyl)-2-(dipropylamino)acetamide
2',6'-Acetoxylidide, 4'-(benzyloxy)-2-(dipropylamino)-
N-[2,6-DIMETHYL-4-(PHENYLMETHOXY)PHENYL]-2-(DIPROPYLAMINO)ACETAMIDE
DTXCID6091394
2',6'-Acetoxylidide, 4'-(benzyloxy)-2-(dipropylamino)-(8CI)