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Fluorouracil

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Identification
Molecular formula
C4H3FN2O2
CAS number
51-21-8
IUPAC name
N-[4-[bis(2-chloroethyl)amino]phenyl]-2-fluoro-acetamide
State
State

Fluorouracil is typically found as a solid at room temperature.

Melting point (Celsius)
282.30
Melting point (Kelvin)
555.40
Boiling point (Celsius)
231.80
Boiling point (Kelvin)
505.00
General information
Molecular weight
130.08g/mol
Molar mass
130.0770g/mol
Density
1.6830g/cm3
Appearence

Fluorouracil appears as a white to nearly white crystalline powder.

Comment on solubility

Solubility of N-[4-[bis(2-chloroethyl)amino]phenyl]-2-fluoro-acetamide

N-[4-[bis(2-chloroethyl)amino]phenyl]-2-fluoro-acetamide presents a unique profile when it comes to solubility. Understanding the solubility characteristics of this compound is crucial, particularly in applications related to pharmaceuticals and chemical processes.

Generally, the solubility of chemical compounds can be influenced by several factors, including:

  • Polarity: The presence of polar functional groups in a compound can enhance its solubility in polar solvents, while non-polar regions may increase solubility in non-polar solvents.
  • Temperature: As temperature increases, the solubility of many solids typically increases, allowing for greater dissolution in solvents.
  • pH Levels: The ionization state of a compound can vary with pH, affecting its solubility in aqueous environments.

For N-[4-[bis(2-chloroethyl)amino]phenyl]-2-fluoro-acetamide:

  • It is expected to have moderate solubility in water due to the polar nature introduced by the acetamide group.
  • However, its solubility may be reduced by the presence of chlorinated alkyl groups, which typically exhibit lower solubility in polar solvents.
  • In organic solvents, it may demonstrate enhanced solubility, making it more compatible with various chemical reactions.

In conclusion, while N-[4-[bis(2-chloroethyl)amino]phenyl]-2-fluoro-acetamide demonstrates some potential for solubility in water, the balance of its structure suggests that solubility may vary widely depending on the solvent system used.

Interesting facts

Interesting Facts about N-[4-[bis(2-chloroethyl)amino]phenyl]-2-fluoro-acetamide

N-[4-[bis(2-chloroethyl)amino]phenyl]-2-fluoro-acetamide is a significant compound in the realm of medicinal chemistry, particularly known for its *antitumor properties.* Below are some intriguing details about this compound:

  • Pharmaceutical Relevance: This compound is related to alkylating agents, which are used in the treatment of various cancers. Its ability to interact with DNA makes it a candidate for research in cancer therapies.
  • Mechanism of Action: It operates by modifying DNA structure, leading to cell death. This characteristic is crucial for its effectiveness in targeting rapidly dividing cancer cells.
  • Structure Analysis: The presence of both chlorine and fluorine atoms in the molecular structure introduces unique electronic properties, enabling it to bind effectively to biological targets.
  • Side Effects: As with many anticancer agents, there can be *considerable side effects* due to its mechanism of action, necessitating ongoing research to improve selectivity and reduce toxicity.
  • Research Frontiers: Studies are continuously aimed at enhancing the compound's efficacy and minimizing adverse effects, with a focus on *novel delivery systems* that can target tumors more precisely.

This compound illustrates the intricate balance between *therapeutic benefits* and *potential risks,* making it a compelling subject for both science students and seasoned researchers alike. As medicinal chemistry evolves, compounds like N-[4-[bis(2-chloroethyl)amino]phenyl]-2-fluoro-acetamide stand at the forefront of cancer treatment innovations.

Synonyms
1492-93-9
N-[4-[bis(2-chloroethyl)amino]phenyl]-2-fluoroacetamide
p-Fluoroacetylaminophenyl derivative of nitrogen mustard
ACETANILIDE, 4'-(BIS(2-CHLOROETHYL)AMINO)-2-FLUORO-
4'-(Bis(2-chloroethyl)amino)-2-fluoroacetanidide
4'-(Bis(2-chloroethyl)amino)-2-fluoroacetanilide
4'-[BIS(2-CHLOROETHYL)AMINO]-2-FLUOROACETANILIDE
4/'-[Bis(2-chloroethyl)amino]-2-fluoroacetanilide
Acetanilide, 4'-[bis(2-chloroethyl)amino]-2-fluoro-
Acetamide, N-(4-(bis(2-chloroethyl)amino)phenyl)-2-fluoro-
Acetamide, N-[4-[bis(2-chloroethyl)amino]phenyl]-2-fluoro-
4'-[Bis(2-chloroethyl)amino]-2-fluoroacetanidide
NSC 240362
BRN 2815229
Fluoroacetyl-N-(p-aminophenyl)-nitrogen mustard
N-(p-(alpha-Fluoroacetylamino)phenyl)-2,2'-dichlorodiethylamine
WLN: G2N2GR DMV1F
4-13-00-00138 (Beilstein Handbook Reference)
SCHEMBL3498956
DTXSID20164198
NSC240362
NSC-240362