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Amiadorone

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Identification
Molecular formula
C14H16I2N2O
CAS number
1951-25-3
IUPAC name
N-[4-[bis(2-iodoethyl)amino]phenyl]acetamide
State
State

At room temperature, the compound is typically in a crystalline solid form.

Melting point (Celsius)
149.80
Melting point (Kelvin)
422.90
Boiling point (Celsius)
582.30
Boiling point (Kelvin)
855.50
General information
Molecular weight
545.15g/mol
Molar mass
545.1530g/mol
Density
2.3485g/cm3
Appearence

The compound generally appears as a white to off-white crystalline powder. It may also occur in a solid form that is stable under normal conditions.

Comment on solubility

Solubility of N-[4-[bis(2-iodoethyl)amino]phenyl]acetamide

N-[4-[bis(2-iodoethyl)amino]phenyl]acetamide is a compound that exhibits unique solubility properties. Understanding its solubility behavior is essential for practical applications in pharmaceutical and chemical research. Here are several key points regarding its solubility:

  • Polar Nature: The presence of the amino group in the structure contributes to a degree of polarity, which can enhance solubility in polar solvents like water.
  • Hydrophobic Interactions: The bis(2-iodoethyl) substituents are hydrophobic, potentially limiting solubility in polar solvents, and suggesting that the compound may be more soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).
  • Temperature Dependence: Solubility may vary significantly with temperature; typically, increased temperatures can lead to enhanced solubility in organic solvents.
  • Influence of pH: The solubility might also be affected by the pH of the solution, as the protonation state of the amino group can influence its solubility characteristics.

In summary, while N-[4-[bis(2-iodoethyl)amino]phenyl]acetamide shows potential for solubility in polar solvents due to its amino group, its overall solubility profile may depend significantly on solvent choice, temperature, and pH conditions. For effective usage, it's crucial to consider these factors when preparing solutions of this compound.

Interesting facts

Interesting Facts about N-[4-[bis(2-iodoethyl)amino]phenyl]acetamide

N-[4-[bis(2-iodoethyl)amino]phenyl]acetamide is a fascinating compound, primarily notable for its potential in medicinal chemistry and therapeutic applications. This compound belongs to a class of molecules known for their ability to interact with biological systems, particularly in cancer research and treatment regimens.

Key Highlights:

  • Mechanism of Action: The compound may exhibit important properties by targeting specific cellular receptors, thereby influencing cellular pathways that are crucial in the development of various diseases.
  • Structure-Activity Relationship (SAR): The unique addition of bis(2-iodoethyl) groups contributes to its potency, leading to a better understanding of how modifications in chemical structure can enhance drug efficacy.
  • Research Potential: Its chemical architecture serves as a promising lead for designing new anticancer agents, particularly due to the iodine atoms which can also play a role in imaging techniques.
  • Biological Insights: Compounds like N-[4-[bis(2-iodoethyl)amino]phenyl]acetamide are often studied for their interactions with DNA and proteins, which can unveil more about cellular mechanisms.
  • Future Directions: Ongoing research focuses on the optimization of this compound to improve its selectivity and reduce possible side effects in therapy.

As researchers delve deeper into the properties and applications of N-[4-[bis(2-iodoethyl)amino]phenyl]acetamide, it is clear that this compound not only exhibits intriguing chemical behavior but also embodies the dynamic intersection of chemistry and biology. As a chemistry student, understanding such compounds can spark a passion for innovative solutions in medicine.

Synonyms
ACETANILIDE, 4'-BIS(2-IODOETHYL)AMINO-
BRN 2811878
2045-11-6
4-(Bis(2-iodoethyl)amino)acetanilide
DTXSID00174396
DTXCID2096887
CHEMBL3246929