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N-(4-bromophenyl)-2-chloroacetamide

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Identification
Molecular formula
C8H7BrClNO
CAS number
1845-90-5
IUPAC name
N-(4-bromophenyl)-2-chloro-acetamide
State
State

At room temperature, N-(4-bromophenyl)-2-chloroacetamide is in a solid state. It is usually stable under standard conditions and can be stored in a cool, dry place.

Melting point (Celsius)
181.00
Melting point (Kelvin)
454.15
Boiling point (Celsius)
314.00
Boiling point (Kelvin)
587.15
General information
Molecular weight
248.50g/mol
Molar mass
248.4970g/mol
Density
1.6015g/cm3
Appearence

N-(4-bromophenyl)-2-chloroacetamide appears as a white to off-white crystalline solid. The compound is generally free-flowing and can form distinct crystals under specific conditions.

Comment on solubility

Solubility Overview of N-(4-bromophenyl)-2-chloro-acetamide

N-(4-bromophenyl)-2-chloro-acetamide, owing to its unique structure, exhibits specific solubility characteristics that can be intriguing for its applications in various fields. This compound generally demonstrates a tendency toward moderate solubility in organic solvents.

  • Solubility in Water: Typically, N-(4-bromophenyl)-2-chloro-acetamide is poorly soluble in water due to its hydrophobic aromatic groups.
  • Solubility in Organic Solvents: It tends to dissolve better in polar organic solvents, such as:
    • Dimethyl sulfoxide (DMSO)
    • Dimethylformamide (DMF)
    • Acetonitrile
  • Factors Influencing Solubility: The solubility can be influenced by several factors:
    • Temperature: Increased temperatures may enhance solubility.
    • pH levels: Variations in pH can affect the protonation state of the compound, altering its solubility.
    • Presence of other solutes: Co-solute interactions might facilitate or hinder solubility.

In summary, N-(4-bromophenyl)-2-chloro-acetamide exhibits limited water solubility but is more amenable to dissolution in various organic solvents, making it versatile for use in different chemical environments.

Interesting facts

Interesting Facts about N-(4-bromophenyl)-2-chloro-acetamide

N-(4-bromophenyl)-2-chloro-acetamide is a fascinating compound that highlights the intricate relationship between chemical structure and biological activity. This compound is a member of the class of amides, which are characterized by the presence of a carbonyl group (C=O) linked to a nitrogen atom (N). The unique structural components of this molecule lead to several interesting characteristics:

  • Pharmacological Relevance: Compounds with similar structures have been studied for their potential as pharmaceuticals, specifically in the treatment of various diseases due to their ability to interact with biological pathways.
  • Substituent Effects: The bromine and chlorine substituents play a crucial role in the compound's reactivity and interactions. Bromine, being larger and more polarizable, can influence the molecular behavior significantly.
  • Inhibition Studies: Studies have suggested that amide compounds can act as inhibitors in enzymatic processes, making them subjects of interest in enzymology research.
  • Analogous Structures: The presence of the phenyl group and halogens in the structure allows scientists to explore derivatives and analogs, paving the way for the development of new compounds with enhanced properties.

In the realm of synthetic chemistry, the synthesis of N-(4-bromophenyl)-2-chloro-acetamide provides a robust example of how strategic modifications to a precursor compound can yield diverse chemical entities.

Quotes from Research

As noted in recent studies, “the design and modification of amides can lead to significant improvements in bioactivity.” This sentiment captures the essence of why compounds like N-(4-bromophenyl)-2-chloro-acetamide are vital in chemical research.

Through its various applications and the wealth of research it inspires, N-(4-bromophenyl)-2-chloro-acetamide stands as a testament to the complexity and utility of chemical compounds in modern science.

Synonyms
N-(4-Bromophenyl)-2-chloroacetamide
2564-02-5
Acetamide, N-(4-bromophenyl)-2-chloro-
ACETANILIDE, 4'-BROMO-2-CHLORO-
4'-Bromo-2-chloroacetanilide
MFCD00018903
NSC-220248
Acetamide,N-(4-bromophenyl)-2-chloro-
NSC220248
NSC 220248
BRN 0639451
N-(4-Bromo-phenyl)-2-chloro-acetamide
WLN: G1VMR DE
CBChromo1_000033
CBDivE_001875
2-Chloro-4'-bromoacetanilide
SCHEMBL1948373
N-(Chloroacetyl)-4-bromoaniline
DTXSID70180323
N-(4-Bromophenyl)chloroacetamide
S44D458BY3
ALBB-002249
2-Chloro-N-(p-bromophenyl)acetamide
STK117938
2-Chloro-N-(4-bromophenyl)acetamide
AKOS000263818
N-(4-bromophenyl)-2-chloro-acetamide
AS-8251
N-(4-Bromophenyl)-alpha-chloroacetamide
DB-004783
CS-0064109
EN300-17262
W11889
3-12-00-01437 (Beilstein Handbook Reference)
Z56899212
F1285-0976
InChI=1/C8H7BrClNO/c9-6-1-3-7(4-2-6)11-8(12)5-10/h1-4H,5H2,(H,11,12