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Bromofluoroacetamide

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Identification
Molecular formula
C9H9BrFNO
CAS number
443-74-7
IUPAC name
N-(4-bromophenyl)-2-fluoro-N-methyl-acetamide
State
State

At room temperature, N-(4-bromophenyl)-2-fluoro-N-methyl-acetamide is a solid. Its stability as a solid under normal conditions makes it suitable for handling and storage in a chemical laboratory or industrial setting.

Melting point (Celsius)
112.50
Melting point (Kelvin)
385.60
Boiling point (Celsius)
311.50
Boiling point (Kelvin)
584.60
General information
Molecular weight
246.07g/mol
Molar mass
246.0590g/mol
Density
1.5775g/cm3
Appearence

N-(4-bromophenyl)-2-fluoro-N-methyl-acetamide appears as a white to off-white crystalline solid. This compound is characterized by its crystalline structure, which is typical for many aromatic amide derivatives. Its purity and coloration can vary slightly depending on the presence of impurities.

Comment on solubility

Solubility of N-(4-bromophenyl)-2-fluoro-N-methyl-acetamide

N-(4-bromophenyl)-2-fluoro-N-methyl-acetamide, with the chemical formula C9H9BrFNO, exhibits notable solubility characteristics that can be understood through several key factors:

  • Polarity: The presence of polar functional groups, such as the acetamide group, tends to increase solubility in polar solvents like water.
  • Hydrogen Bonding: The amide functionality can engage in hydrogen bonding, enhancing interactions with solvents that are capable of hydrogen bonding.
  • Impact of Bromine and Fluorine: The bromine and fluorine substituents can influence solubility; bromine, being relatively large, may impart a degree of hydrophobicity, while fluorine can enhance polarity.

In general, compounds like N-(4-bromophenyl)-2-fluoro-N-methyl-acetamide tend to exhibit moderate solubility in organic solvents, such as ethanol and acetone, while their solubility in water might be lower due to a combination of factors like steric hindrance from the bromine atom and the balance of polar/nonpolar characteristics.

As with many organic compounds, it is essential to conduct empirical tests to accurately determine solubility, as theoretical predictions may vary significantly based on environmental conditions.

Interesting facts

Interesting Facts About N-(4-bromophenyl)-2-fluoro-N-methyl-acetamide

N-(4-bromophenyl)-2-fluoro-N-methyl-acetamide is a fascinating compound within the realm of medicinal chemistry, particularly due to its potential applications in pharmaceutical development. Here are some intriguing aspects of this compound:

  • Structural Diversity: This compound features a unique combination of functional groups, including a 1 bromo group and a 2 fluoro group, which can influence both its chemical properties and biological activity.
  • Potential Applications: Due to its structure, it may exhibit properties suitable for use as an analgesic or anti-inflammatory agent, making it a candidate for drug development.
  • Mechanistic Insights: The presence of the fluorine atom can enhance metabolic stability and modulate the compound's affinity to biological targets, which is crucial in drug design.
  • Syntheses: The synthesis of N-(4-bromophenyl)-2-fluoro-N-methyl-acetamide involves several reaction steps, showcasing the intricacies of modern organic synthesis techniques.

As a student of chemistry, exploring compounds like this one not only broadens your understanding of molecular interactions but also highlights the importance of molecular design in the quest for new therapeutics. "Understanding the subtleties of compound structure can pave the way for innovative solutions in drug discovery."

This compound serves as an excellent example of how small changes in chemical structure can lead to significant variations in biological activity and pharmacological effects. Studying such compounds can inspire future research and the development of novel therapies.

Synonyms
10385-00-9
4'-Bromo-2-fluoro-N-methylacetanilide
BRN 2102042
ACETANILIDE, 4'-BROMO-2-FLUORO-N-METHYL-
DTXSID20146111
DTXCID0068602
N-(4-bromophenyl)-2-fluoro-N-methylacetamide
4/'-Bromo-2-fluoro-N-methylacetanilide