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Brompheniramine

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Identification
Molecular formula
C16H19BrN
CAS number
86-22-6
IUPAC name
N-[(4-bromophenyl)methyl]-1,7,7-trimethyl-norbornan-2-amine
State
State

At room temperature, brompheniramine is typically in a solid state, appearing as a white to off-white crystalline powder. It is stable under normal temperatures and pressures, which makes it suitable for storage and handling in typical pharmaceutical environments.

Melting point (Celsius)
117.00
Melting point (Kelvin)
390.15
Boiling point (Celsius)
522.90
Boiling point (Kelvin)
796.05
General information
Molecular weight
435.31g/mol
Molar mass
435.3110g/mol
Density
1.2350g/cm3
Appearence

Brompheniramine is typically a white to off-white crystalline powder. It is known for its effectiveness as an antihistamine. The appearance might vary slightly depending on the grade of the chemical, but it is generally crystalline or powder form, making it easy to handle and use in pharmaceutical formulations.

Comment on solubility

Solubility of N-[(4-bromophenyl)methyl]-1,7,7-trimethyl-norbornan-2-amine

The solubility of N-[(4-bromophenyl)methyl]-1,7,7-trimethyl-norbornan-2-amine can vary significantly depending on various factors, including the solvent used and the temperature. Understanding the solubility characteristics of this compound is essential for applications in chemical synthesis and formulation processes.

Key Aspects of Solubility:

  • Polarity: The presence of both a bromophenyl group and an amine functional group suggests that this compound could exhibit moderate polarity, which may impact its ability to dissolve in different solvents.
  • Solvent Selection: This compound may be more soluble in polar aprotic solvents such as acetone or DMSO, while showing reduced solubility in nonpolar organic solvents like hexane.
  • Temperature Effect: Generally, increased temperature can enhance the solubility of organic compounds by increasing molecular motion, therefore, it might be advisable to test solubility at varying temperatures.
  • Hydrogen Bonding: The amine group could partake in hydrogen bonding, potentially improving solubility in polar solvents that can participate in hydrogen bonding interactions.

In practical scenarios, conducting solubility tests under controlled conditions is highly recommended to establish reliable data. Furthermore, observing the crystallization behavior during solvent evaporation might provide additional insights into the solubility characteristics of this compound.

Interesting facts

Interesting Facts about N-[(4-bromophenyl)methyl]-1,7,7-trimethyl-norbornan-2-amine

N-[(4-bromophenyl)methyl]-1,7,7-trimethyl-norbornan-2-amine is a fascinating compound belonging to the class of amines, with intriguing structural features that contribute to its chemical behavior and potential applications. Here are some noteworthy points:

  • Unique Structure: The compound incorporates a norbornane backbone, known for its strain and rigidity. This unique framework can impact its reactivity and interactions.
  • Substituent Influence: The presence of the 4-bromophenyl group plays a crucial role in establishing the compound's reactivity and pharmacological profile. Bromine, being a halogen, can enhance lipophilicity and influence molecular interactions.
  • Potential Applications: Compounds of this nature are often explored in medicinal chemistry. They may serve as precursors or templates for drug development, especially within the realm of receptor binding studies due to their ability to mimic bioactive molecules.
  • Chirality: The asymmetric nature of the norbornane skeleton may give rise to stereoisomerism, resulting in distinct biological activities among its enantiomers. Understanding this aspect is vital in drug design.
  • Research Interest: Scientists are intrigued by complexes compounds like this one due to their potential in developing selective therapeutics that can target specific biological pathways.

In conclusion, N-[(4-bromophenyl)methyl]-1,7,7-trimethyl-norbornan-2-amine exemplifies the complexity and beauty of organic chemistry, where intricate structures hold the key to understanding behavior, reactivity, and potential innovations in science.

Synonyms
AKOS006036717