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Brompheniramine

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Identification
Molecular formula
C16H19BrClNO
CAS number
86-22-6
IUPAC name
N-[(4-bromophenyl)methyl]-N-(2-chloroethyl)-2-(2-isopropyl-5-methyl-phenoxy)ethanamine
State
State

Brompheniramine is found in a solid state at room temperature.

Melting point (Celsius)
117.00
Melting point (Kelvin)
390.15
Boiling point (Celsius)
397.10
Boiling point (Kelvin)
670.25
General information
Molecular weight
435.35g/mol
Molar mass
435.3540g/mol
Density
1.3000g/cm3
Appearence

Brompheniramine is typically a white to off-white crystalline powder.

Comment on solubility

Solubility of N-[(4-bromophenyl)methyl]-N-(2-chloroethyl)-2-(2-isopropyl-5-methyl-phenoxy)ethanamine

The solubility of the compound N-[(4-bromophenyl)methyl]-N-(2-chloroethyl)-2-(2-isopropyl-5-methyl-phenoxy)ethanamine can be influenced by a variety of factors, including its molecular structure and the presence of functional groups. Here are some key points to consider:

  • Solvent Type: Solubility is often determined by the interaction of the compound with various solvents. For this compound, polar solvents like water tend to show lower solubility due to its hydrophobic characteristics, whereas it may be more soluble in non-polar organic solvents like ethanol or chloroform.
  • Functional Groups: The presence of the aromatic ring and alkyl groups in this compound suggests potential hydrophobic interactions, affecting solubility. Compounds with similar structures often exhibit enhanced solubility in organic solvents due to their non-polar nature.
  • Molecular Interactions: The branching of the isopropyl and the chlorinated ethyl groups can lead to steric hindrance, thereby impacting the effectiveness of solvation in polar environments, further reducing solubility in such cases.
  • Temperature Effects: In general, the solubility of organic compounds can increase with temperature. Therefore, heating may enhance the solubility of this compound in selected organic solvents.

In summary, while the solubility of N-[(4-bromophenyl)methyl]-N-(2-chloroethyl)-2-(2-isopropyl-5-methyl-phenoxy)ethanamine may not be significant in water, it could exhibit considerable solubility in non-polar solvents. Understanding the solubility profile is crucial for applications in organic synthesis and formulation development.

Interesting facts

Interesting Facts about N-[(4-bromophenyl)methyl]-N-(2-chloroethyl)-2-(2-isopropyl-5-methyl-phenoxy)ethanamine

This compound is a fascinating example of a synthesized amine that showcases the intricate relationship between molecular structure and biological activity. Here are some intriguing insights:

  • Complex Structure: The compound features a multi-substituted aromatic system, which is significant in medicinal chemistry. The presence of a bromophenyl group and a chloroethyl moiety suggests potential applications in pharmaceuticals and agrochemicals.
  • Biological Activity: Compounds with similar structures have been studied for their efficacy as antidepressants, antipsychotics, and anti-inflammatory agents. Its unique substitution on the phenoxy ring may also influence its pharmacological properties.
  • Synthetic Pathways: The synthesis of such complex molecules often involves several steps of organic synthesis, demonstrating the skill required in modern chemistry labs to manipulate and assemble intricate molecular frameworks.
  • Structure-Activity Relationship (SAR): Understanding how different substituents affect the biological activity of the compound is crucial. This compound can serve as a template for designing analogs with improved efficacy or reduced side effects.
  • Environmental Considerations: The presence of halides (bromine and chlorine) in its structure warrants careful consideration regarding environmental impact and toxicity. The study of such compounds often includes their stability and degradation pathways in various environments.

In summary, N-[(4-bromophenyl)methyl]-N-(2-chloroethyl)-2-(2-isopropyl-5-methyl-phenoxy)ethanamine illustrates the deep interplay between structure, synthesis, and function in chemistry. Its diverse applications and the ongoing research into its properties reflect the vast potential of organic compounds in advancing health and technology.