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L-745,870

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Identification
Molecular formula
C21H22ClN3O3
CAS number
153253-65-5
IUPAC name
N-[4-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide
State
State

At room temperature, L-745,870 is a solid. It is stable under normal conditions and does not tend to volatilize. The compound is typically handled in solid form in laboratory settings.

Melting point (Celsius)
246.00
Melting point (Kelvin)
519.15
Boiling point (Celsius)
620.00
Boiling point (Kelvin)
893.15
General information
Molecular weight
468.87g/mol
Molar mass
468.9510g/mol
Density
1.3870g/cm3
Appearence

L-745,870 is typically a solid crystalline substance. It appears as a white to off-white powder and may vary in texture from fine to slightly granular, depending on the crystallization process used.

Comment on solubility

Solubility of N-[4-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide

The solubility of N-[4-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide can be influenced by various factors. Understanding its solubility profile is crucial for both research and application in medicinal chemistry.

Factors Affecting Solubility

  • Polarity: The overall polarity of the molecule plays a significant role. The presence of polar functional groups can enhance solubility in polar solvents.
  • Hydrogen Bonding: Potential hydrogen bond donors and acceptors can significantly improve solubility in water.
  • Molecular Size: Larger molecules may have reduced solubility due to steric hindrance.
  • pH of the Solution: Adjusting the pH can help increase solubility for acid-base compounds.

It is often observed that compounds with more complex structures tend to exhibit diverse solubility characteristics. For instance:

  • Aqueous Solubility: This compound may have limited solubility in water due to its bulky aromatic groups.
  • Organic Solvents: It is likely to show better solubility in organic solvents like DMSO, ethanol, or methanol, which can accommodate larger, more lipophilic molecules.

In summary, while specific solubility data may be limited, factors such as polarity, hydrogen bonding potential, and solvent choice will significantly dictate the solubility of N-[4-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide. As with many chemical compounds, tailored solubility studies are recommended to optimize conditions for desired applications.

Interesting facts

Interesting Facts about N-[4-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide

This intriguing compound belongs to a class of molecules known for their diverse biological activities, particularly in medicinal chemistry. Here's what makes it stand out:

  • Pharmaceutical Relevance: This compound is often studied for its potential as a therapeutic agent. Research indicates that derivatives of benzamide can exhibit significant antitumor, anti-inflammatory, and analgesic properties.
  • Structure-Activity Relationship (SAR): The presence of the morpholino group is particularly noteworthy as it can enhance the lipophilicity and metabolic stability of the compound, potentially improving its bioavailability and therapeutic effectiveness.
  • Chlorine Substitution: The 4-chloro substituent on the phenyl ring plays a critical role in modulating the compound's electronic properties, which can, in turn, influence receptor binding affinities and the overall pharmacodynamic profile.
  • Mechanism of Action: Many compounds like this one are designed to interact with specific biological targets, such as enzymes or receptors. Understanding its mechanism of action could pave the way for novel treatment strategies in various diseases.

As chemists continue to explore the landscape of synthetic medicinal chemistry, compounds such as N-[4-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide remind us of the intricate connections between structure, function, and therapeutic potential:

"The beauty of chemistry lies not just in its complexity but in its ability to unlock the mysteries of nature and improve human health."

As research progresses, scientists remain optimistic that compounds like this will lead to breakthroughs in treatments across multiple fields of medicine.