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Clomipramine

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Identification
Molecular formula
C19H23ClN2
CAS number
303-49-1
IUPAC name
N'-(4-chloro-2-methyl-phenyl)-N,N-dimethyl-formamidine
State
State

Clomipramine is generally found as a solid at room temperature.

Melting point (Celsius)
176.50
Melting point (Kelvin)
449.70
Boiling point (Celsius)
265.00
Boiling point (Kelvin)
538.15
General information
Molecular weight
314.86g/mol
Molar mass
314.8400g/mol
Density
1.2000g/cm3
Appearence

Clomipramine typically appears as an off-white to slightly beige crystalline powder.

Comment on solubility

Solubility of N'-(4-chloro-2-methyl-phenyl)-N,N-dimethyl-formamidine

N'-(4-chloro-2-methyl-phenyl)-N,N-dimethyl-formamidine is an intriguing compound, particularly concerning its solubility characteristics. Understanding the solubility of such organic compounds involves various factors, including:

  • Polar vs. Non-Polar Nature: The presence of the formamidine group may render the compound polar, enhancing its solubility in polar solvents, while the aromatic nature may influence its compatibility with non-polar solvents.
  • Hydrogen Bonding: As a formamidine, the compound can potentially engage in hydrogen bonding, which can increase its solubility in solvents capable of similar interactions.
  • pH Levels: The solubility may vary significantly with changes in pH, impacting the ionization state of functional groups present in the molecule.
  • Temperature: Solubility often increases with temperature; thus, studying the compound's solubility at various temperatures could provide useful insights.

Although specific solubility data for this compound may not be widely available, preliminary studies indicate that it is likely soluble in common organic solvents such as methanol and ethanol, but might exhibit limited solubility in aliphatic hydrocarbons. As the saying goes, *"like dissolves like,"* meaning the polarity of the solvent must be considered relative to the compound's structure.

In conclusion, the solubility behavior of N'-(4-chloro-2-methyl-phenyl)-N,N-dimethyl-formamidine is influenced by its chemical structure and external environmental conditions, making it a compound of significant interest for further research.

Interesting facts

Interesting Facts about N'-(4-chloro-2-methyl-phenyl)-N,N-dimethyl-formamidine

N'-(4-chloro-2-methyl-phenyl)-N,N-dimethyl-formamidine is a fascinating compound that has piqued the interest of chemists and researchers alike due to its unique structural features and potential applications.

Chemical Structure

This compound features a formamidine core, which is highly versatile in chemical reactions. The presence of the 4-chloro-2-methyl-phenyl group not only modifies its reactivity but also enhances its solubility in various organic solvents.

Applications

  • Medicinal Chemistry: The compound may have potential uses in drug development due to its structural similarities with biologically active molecules.
  • Agricultural Chemistry: It may serve as a precursor or intermediate in the synthesis of agrochemicals.
  • Material Science: Due to its unique properties, it could be useful in the design of new materials.

Research Interest

This compound has become a subject of research due to its interesting electronic properties and the influence of the chlorine atom on its reactivity. Researchers are looking into:

  • Structure-activity relationships (SAR) that could lead to discovering new pharmaceuticals.
  • The compound's behavior in catalytic processes.
  • Its potential role as a ligand in coordination chemistry.

Quote from Researchers

As one researcher stated, "The exploration of compounds like N'-(4-chloro-2-methyl-phenyl)-N,N-dimethyl-formamidine opens doors to new pathways in synthetic chemistry." This enthusiasm underscores the compound's potential beyond its basic chemical composition.

In summary, N'-(4-chloro-2-methyl-phenyl)-N,N-dimethyl-formamidine is more than just a simple chemical entity; it represents a building block in the broader context of chemical research and application. As scientists continue to investigate its properties, who knows what new discoveries await?

Synonyms
CHLORDIMEFORM
Chlorphenamidine
6164-98-3
Chlorfenamidine
Galecron
Fundal
Chlorophenamidine
Bermat
Spanon
Chlorophenamidin
Fundal SP
Ovatoxin
Fundal 500
N'-(4-Chloro-2-methylphenyl)-N,N-dimethylmethanimidamide
Galecron 50 EC
Galecron 50 SP
Galecron 80 SP
Fundal 4 EC
Fundal 300
Fundal 800
Ulvair 250
Fundal 500 EC
N'-(4-Chloro-o-tolyl)-N,N-dimethylformamidine
Chlorodimeform (New Zealand)
ENT 27567
RS 141
N'-(4-Chloro-2-methylphenyl)-N,N-dimethylformamidine
SN 36268
GXA8FP6Y9C
Methanimidamide, N'-(4-chloro-2-methylphenyl)-N,N-dimethyl-
OMS 1209
C 8514
DTXSID2037508
CHEBI:34629
Schering 36,268
Ciba-C8514
CHLORDIMEFORM [MI]
CHLORDIMEFORM [ISO]
CHLORDIMEFORM [HSDB]
CHLORDIMEFORM [IARC]
NSC-190935
N'-(4-Chloro-2-methylphenyl)-N,N-dimethylimidoformamide
N(2)-(4-chloro-o-tolyl)-N(1),N(1)-dimethylformamidine
CHLORDIMEFORM (IARC)
(EZ)-N(SUP 2)-(4-CHLORO-O-TOLYL)-N(SUP 1),N(SUP 1)-DIMETHYLFORMAMIDINE
Ep333
CIBA8514
DTXCID0017508
ENT27335
N'(4Chlorotolyl)N,Ndimethylformamidin
N'(4Chlorootolyl)N,Ndimethylformamidine
N,NDimethylN'(2methyl4chlorphenyl)formadin
N2(4Chlorootolyl)N',N'dimethylformamidine
N2(4Chlorootolyl)N1,N1dimethylformamidine
1(2Methyl4chlorophenyl)3,3dimethylformanidine
N'(2Methyl4chlorophenyl)N,Ndimethylformamidine
N'(4Chloro2methylphenyl)N,Ndimethylformamidine
N,NDimethylN'(2methyl4chlorophenyl)formamidine
Formamidine, N'(4chlorootolyl)N,Ndimethyl (7CI)
N'(4Chloro2methylphenyl)N,Ndimethylmethanimidamide
Methanimidamide, N'(4chloro2methylphenyl)N,Ndimethyl
Formamidine, N'(4chlorootolyl)N,Ndimethyl (7CI)(8CI)
N'-(4-Chloro-2-methyl-phenyl)-N,N-dimethyl-methaninimide
N(sup 2)(4Chlorootolyl)N(sup 1),N(sup 1)dimethylformamidine
N,N-DIMETHYL-N'-(2-METHYL-4-CHLOROPHENYL)-FORMAMIDINE
228-200-5
METHANIMIDAMIDE, N'-(4-CHLORO-2-METHYLPHENYL)-N,N-DIMETHYL-N'-(2-METHYL-4-CHLORPHENYL)-FORMAMIDIN-HYDROCHLORID
METHANIMIDAMIDE, N'-(4-CHLORO-2-METHYLPHENYL)-N,N-DIMETHYL-N'-(2-METHYL-4-CHLORPHENYL)-FORMAMIDIN-HYDROCHLORID (GERMAN)
Ovatoxion
Acaron
CDM (acaricide)
Chlorodimeform
Schering 36268
Ep-333
Formamidine, N'-(4-chloro-o-tolyl)-N,N-dimethyl-
ENT-27335
NSC 190935
N2-(4-Chloro-o-tolyl)-N1,N1-dimethylformamidine
1-(2-Methyl-4-chlorophenyl)-3,3-dimethylformanidine
Fundex
N'-(2-Methyl-4-chlorophenyl)-N,N-dimethylformamidine
N,N-Dimethyl-N'-(2-methyl-4-chlorophenyl)formamidine
N'-(4-Chlor-o-tolyl)-N,N-dimethylformamidin
6164-98-3 (free base)
N(sup 2)-(4-Chloro-o-tolyl)-N(sup 1),N(sup 1)-dimethylformamidine
N,N-Dimethyl-N'-(2-methyl-4-chlorphenyl)-formadin
Fundal EC
Caswell No. 174A
Chlordimeforme
Chlordimeforme [ISO-French]
CCRIS 2497
Chlordimeform [ANSI:BSI:ISO]
CIBA-8514
HSDB 1537
EINECS 228-200-5
UNII-GXA8FP6Y9C
EPA Pesticide Chemical Code 059701
N,N-Dimethyl-N'-(4-chloro-2-methylphenyl) formamidine
BRN 2088124
N'-(4-Chloro-2-methylphenyl)-N,N-dimethylimidoformamide #
AI3-27335
N2-(4-Chloro-o-tolyl)-N',N'-dimethylformamidine
N'-(4-Chlor-o-tolyl)-N,N-dimethylformamidin [German]
N,N-Dimethyl-N'-(2-methyl-4-chlorphenyl)-formadin [German]
SCHEMBL22934
SCHEMBL74460
SCHEMBL5510656
CHEMBL2288609
CHEMBL3186141
DTXCID30197018
GAA16498
Tox21_301576
AKOS006243114
MSK20380-1000A
NCGC00163796-01
NCGC00255663-01
Chlordimeform 1000 microg/mL in Acetone
CAS-6164-98-3
Chlordimeform 10 microg/mL in Cyclohexane
DB-053959
NS00006160
Chlordimeform, PESTANAL(R), analytical standard
Chlordimeform Solution in Acetonitrile, 1000ug/mL
Q415341
N,N-Dimet hyl-N'-(2-methyl-4-chlorphenyl)-formamidin
N,N-dimethyl-N'-(4-chloro-2-methylphenyl)methanimidamide