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N-(4-chloro-2-methylphenyl)formamide

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Identification
Molecular formula
C8H8ClNO
CAS number
54245-45-7
IUPAC name
N-(4-chloro-2-methyl-phenyl)formamide
State
State

At room temperature, N-(4-chloro-2-methylphenyl)formamide is a solid. It maintains its stability under standard conditions of temperature and pressure.

Melting point (Celsius)
127.00
Melting point (Kelvin)
400.15
Boiling point (Celsius)
369.80
Boiling point (Kelvin)
642.95
General information
Molecular weight
185.63g/mol
Molar mass
185.6330g/mol
Density
1.2683g/cm3
Appearence

N-(4-chloro-2-methylphenyl)formamide appears as a crystalline solid. It is characterized by its specific structure which includes a formamide group attached to a chlorinated and methylated phenyl ring. The compound's crystalline nature can vary in color depending on purity, typically appearing as white to pale yellow crystals.

Comment on solubility

Solubility of N-(4-chloro-2-methyl-phenyl)formamide

N-(4-chloro-2-methyl-phenyl)formamide, with the chemical formula C9H10ClN1O1, exhibits specific solubility characteristics that are worthy of discussion.

Key Solubility Insights

This compound is generally considered to be soluble in:

  • Polar solvents: Like water and alcohols, due to its amide functional group which offers hydrogen bonding capabilities.
  • Organic solvents: Such as dimethyl sulfoxide (DMSO) and acetone, which can stabilize the molecule through dipole interactions.

However, its solubility can be influenced by several factors, including:

  • Temperature: An increase in temperature often enhances solubility.
  • pH Levels: The ionization state of the compound can change in different pH environments, affecting solubility.
  • Concentration: The saturation point in solution can limit further dissolution.

In summary, while N-(4-chloro-2-methyl-phenyl)formamide displays reasonable solubility in a variety of solvents, it's essential to consider the context of use and the specific conditions when evaluating its solubility profile. As a rule of thumb, "like dissolves like," meaning that its interactions with solvents will significantly define its solubility behavior.

Interesting facts

Interesting Facts about N-(4-Chloro-2-methyl-phenyl)formamide

N-(4-chloro-2-methyl-phenyl)formamide is a fascinating compound with a range of applications in the field of chemistry and pharmaceuticals. Below are some intriguing aspects of this compound:

  • Pharmaceutical Relevance: This compound has potential implications in medicinal chemistry. Compounds similar to N-(4-chloro-2-methyl-phenyl)formamide may exhibit bioactive properties, making them candidates for drug development.
  • Versatile Functional Group: The formamide functional group is notable for its ability to participate in various chemical reactions. This versatility can lead to new synthetic pathways in organic chemistry.
  • Influence on Solubility: The presence of the chlorine atom in the aromatic ring influences the compound's solubility and reactivity, presenting opportunities for chemists to manipulate these properties for specific applications.
  • Structural Insights: The specific arrangement of chlorines and methyl groups can provide insight into steric effects, which are essential for understanding molecular interactions and reactivity.
  • Research Applications: Aromatic formamides, including this compound, can be employed in research to study reaction mechanisms and the impact of substituents on chemical behavior.

As a compound that bridges the gap between organic synthesis and medicinal applications, N-(4-chloro-2-methyl-phenyl)formamide exemplifies the complexity and beauty of chemical science. “The exploration of compounds like this one allows us to unravel the mysteries of molecular interactions and their practical implications.”

The investigation of such compounds enhances our understanding of both fundamental chemistry and application in drug design, further showcasing the importance of chemical research in everyday life.

Synonyms
21787-81-5
N-(4-chloro-2-methylphenyl)formamide
4'-Chloro-2-formotoluidide
RefChem:506046
FORMAMIDE, N-(4-CHLORO-2-METHYLPHENYL)-
N-Formyl-4-chloro-o-toluidine
Formamide,N-(4-chloro-2-methylphenyl)-
4'-Chloro-o-formotoluidine
BRN 2639413
o-Formotoluidide, 4'-chloro-
4-Chloro-N-formyl-o-toluidine
4'-Chloro-2'-methylformanilide
4'-chloro-o-formotoluidide
2-formylamino-5-chlorotoluene
SCHEMBL7529690
SCHEMBL7529692
DTXSID2073431
N-Formyl-4-Chloro-2-Toluidine
SCHEMBL11412614
4-chloro-2-methylphenylformamide
JOGQXVYBVVOYGI-UHFFFAOYSA-N
AKOS014313152
3-12-00-01914 (Beilstein Handbook Reference)