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Fluconazole

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Identification
Molecular formula
C13H12ClFN2O
CAS number
86386-73-4
IUPAC name
N-(4-chlorophenyl)-2-fluoro-N-(2-hydroxyethyl)acetamide
State
State

At room temperature, fluconazole is in a solid state. It is stable under normal conditions and is usually administered in the form of tablets, capsules, or oral suspension.

Melting point (Celsius)
138.00
Melting point (Kelvin)
411.15
Boiling point (Celsius)
386.00
Boiling point (Kelvin)
659.15
General information
Molecular weight
306.29g/mol
Molar mass
306.2850g/mol
Density
1.3620g/cm3
Appearence

Fluconazole appears as a white to off-white crystalline powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of N-(4-chlorophenyl)-2-fluoro-N-(2-hydroxyethyl)acetamide

The solubility of N-(4-chlorophenyl)-2-fluoro-N-(2-hydroxyethyl)acetamide can be an intriguing aspect of its chemical behavior. Understanding its solubility properties is essential in various applications, including pharmacology and environmental science. Here are several key points regarding its solubility:

  • Polarity: This compound contains both hydrophobic (the 4-chlorophenyl group) and hydrophilic (the 2-hydroxyethyl group) functional groups, which can influence its interaction with solvents.
  • Solvent Compatibility: N-(4-chlorophenyl)-2-fluoro-N-(2-hydroxyethyl)acetamide is likely to show better solubility in polar solvents like water or alcohol, due to the presence of the –OH group.
  • Temperature Dependence: The solubility may increase with temperature, as is common for many organic compounds, due to enhanced molecular movement.
  • pH Influence: The solubility could also be affected by the pH of the solvent, particularly due to the functional groups capable of protonation or deprotonation.

In summary, the solubility of N-(4-chlorophenyl)-2-fluoro-N-(2-hydroxyethyl)acetamide is influenced by its unique molecular structure, with both polar and non-polar characteristics. Understanding these factors can help optimize its use in various applications.

Interesting facts

Interesting Facts about N-(4-chlorophenyl)-2-fluoro-N-(2-hydroxyethyl)acetamide

N-(4-chlorophenyl)-2-fluoro-N-(2-hydroxyethyl)acetamide is a fascinating organic compound with significant implications in the pharmaceutical and chemical research fields. Here are some key points that make this compound noteworthy:

  • Pharmaceutical Relevance: This compound exhibits properties that can potentially influence the development of drugs targeting various medical conditions due to its unique structure.
  • Substituent Effects: The presence of both the chloro and fluoro groups in its structure allows researchers to study the impact of these halogens on the compound's biological activity.
  • Hydroxyethyl Group: The hydroxyethyl moiety contributes to the compound's solubility and reactivity, making it a point of interest for further chemical modifications.
  • Structure Activity Relationship (SAR): Scientists can investigate how variations in the structure of this compound affect its activity, providing valuable insights into drug design.
  • Potential for Innovation: The complex nature of this compound opens doors for innovative synthetic pathways and applications in medicinal chemistry.

As chemists delve deeper into the properties and potential applications of N-(4-chlorophenyl)-2-fluoro-N-(2-hydroxyethyl)acetamide, they may uncover novel therapeutic agents or materials that can significantly advance the field of chemical science.

Synonyms
10016-08-7
BRN 2124305
4'-Chloro-2-fluoro-N-(2-hydroxyethyl)acetanilide
ACETANILIDE, 4'-CHLORO-2-FLUORO-N-(2-HYDROXYETHYL)-
DTXSID70142986
DTXCID1065477
N-(4-chlorophenyl)-2-fluoro-N-(2-hydroxyethyl)acetamide
4/'-Chloro-2-fluoro-N-(2-hydroxyethyl)acetanilide
ACETANILIDE,4-CHLORO-2-FLUORO-N-(2-HYDROXYETHYL)-