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Chloramphenicol

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Identification
Molecular formula
C8H6ClF3NO
CAS number
2921-88-2
IUPAC name
N-(4-chlorophenyl)-2,2,2-trifluoro-acetamide
State
State

At room temperature, N-(4-chlorophenyl)-2,2,2-trifluoro-acetamide is in a solid state.

Melting point (Celsius)
149.50
Melting point (Kelvin)
422.65
Boiling point (Celsius)
269.50
Boiling point (Kelvin)
542.65
General information
Molecular weight
227.59g/mol
Molar mass
227.5850g/mol
Density
1.5730g/cm3
Appearence

N-(4-chlorophenyl)-2,2,2-trifluoro-acetamide is a white to off-white crystalline powder. It is generally solid at room temperature, with a slight odor.

Comment on solubility

Solubility of N-(4-chlorophenyl)-2,2,2-trifluoro-acetamide

N-(4-chlorophenyl)-2,2,2-trifluoro-acetamide, with its unique structure, exhibits interesting solubility characteristics that are vital for its applications. Understanding its solubility is crucial for predicting its behavior in various solvents. Here are some key points to consider:

  • Polarity: The presence of the trifluoromethyl group and the amide functionality contributes to the compound's overall polarity, enhancing its solubility in polar solvents.
  • Solvent Compatibility: This compound is likely to be soluble in:
    • Polar organic solvents (e.g., DMSO, methanol)
    • Aqueous solutions, to some extent, due to hydrogen bonding capabilities
  • Insolubility: It may show limited solubility in non-polar solvents, owing to its polar functional groups.
  • Temperature Dependence: Solubility can also vary significantly with temperature; usually, an increase in temperature improves solubility.

In summary, the solubility of N-(4-chlorophenyl)-2,2,2-trifluoro-acetamide is influenced by its chemical structure and the interactions with different solvents. As the saying goes, "like dissolves like," and understanding this relationship can help in effectively utilizing this compound in various chemical processes.

Interesting facts

Interesting Facts about N-(4-Chlorophenyl)-2,2,2-trifluoro-acetamide

N-(4-Chlorophenyl)-2,2,2-trifluoro-acetamide is a fascinating compound with a diverse range of applications in both research and industry. Here are some noteworthy aspects:

  • Structural Significance: The presence of a 4-chlorophenyl moiety and trifluoroacetyl group imparts unique chemical properties, making it a subject of interest in various chemical syntheses.
  • Pharmacological Potential: Compounds with similar structures have been studied for their biological activity, particularly as potential pharmaceuticals. Their interactions with biological targets can lead to exciting advancements in drug development.
  • Versatile Reagent: It can serve as an effective reagent in organic synthesis, particularly in the preparation of other complex molecules, thanks to its reactivity and ability to participate in coupling reactions.
  • Environmental Impact: Given the presence of fluorine in the structure, it is essential to consider the compound's environmental persistence. Fluorinated compounds often exhibit unique degradation pathways that can influence ecological studies.

In summary, N-(4-chlorophenyl)-2,2,2-trifluoro-acetamide is not just another compound; it bridges the gap between advanced organic synthesis and biological research. Its intriguing chemical characteristics and potential applications underscore the importance of studying such compounds to unlock new scientific possibilities.

Synonyms
N-(4-chlorophenyl)-2,2,2-trifluoroacetamide
404-25-1
Acetamide, N-(4-chlorophenyl)-2,2,2-trifluoro-
ACETANILIDE, 4'-CHLORO-2,2,2-TRIFLUORO-
NSC 54129
4'-Chloro-2,2,2-trifluoroacetanilide
BRN 2107044
NSC54129
MFCD00519715
SCHEMBL5550330
DTXSID90193399
HMS1787G04
NSC-54129
STL481471
N-(4-chlorophenyl)-trifluoroacetamide
AKOS001033519
11K-343S
CS-0294154
2,2,2-trifluoro-N-(4-chlorophenyl)acetamide
E89475
SR-01000307877
SR-01000307877-1
Z56761384