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4-Chloroacetanilide

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Identification
Molecular formula
C8H8ClNO
CAS number
539-03-7
IUPAC name
N-(4-chlorophenyl)-N-hydroxy-acetamide
State
State

At room temperature, 4-Chloroacetanilide exists as a solid. Its crystalline structure contributes to its stability and appearance.

Melting point (Celsius)
162.50
Melting point (Kelvin)
435.65
Boiling point (Celsius)
318.90
Boiling point (Kelvin)
592.05
General information
Molecular weight
185.61g/mol
Molar mass
185.6280g/mol
Density
1.3830g/cm3
Appearence

4-Chloroacetanilide appears as a white to off-white crystalline solid. It is slightly soluble in water, displaying typical behavior for an aromatic compound with both polar and non-polar characteristics due to the chloro and acetamide groups present.

Comment on solubility

Solubility of N-(4-chlorophenyl)-N-hydroxy-acetamide

N-(4-chlorophenyl)-N-hydroxy-acetamide, often recognized for its unique structural characteristics, displays interesting solubility properties. Solubility is a crucial factor in determining how a compound behaves in various environments, particularly in biological systems.

Some key aspects of its solubility include:

  • Polarity: The presence of both the chlorophenyl group and the hydroxy group contributes to the overall polarity of the molecule, enhancing its interactions with polar solvents.
  • Solvent Compatibility: This compound is likely to be soluble in polar solvents such as water and alcohols, while showing reduced solubility in non-polar organic solvents.
  • Temperature Dependence: Like many organic compounds, the solubility of N-(4-chlorophenyl)-N-hydroxy-acetamide may increase with temperature, making it essential to consider thermal conditions in practical applications.

In summary, the solubility of N-(4-chlorophenyl)-N-hydroxy-acetamide is influenced by its chemical structure and the nature of the solvent. As it is often the case, understanding these properties can provide valuable insights into its practical applications and behavior in various environments.

Interesting facts

Interesting Facts about N-(4-chlorophenyl)-N-hydroxy-acetamide

N-(4-chlorophenyl)-N-hydroxy-acetamide is a fascinating compound that unveils various intriguing aspects from its structure to its applications. Here are some noteworthy points:

  • Chemical Structure: This compound features a chlorophenyl group, which is renowned for its influence on biological activity. The presence of the 4-chlorine substituent plays a crucial role in enhancing its efficacy.
  • Pharmaceutical Relevance: N-(4-chlorophenyl)-N-hydroxy-acetamide has garnered attention for its potential applications in medicinal chemistry. Compounds containing the hydroxyamide functional group are often studied for their role in drug design, particularly in developing analgesics and anti-inflammatory agents.
  • Mechanism of Action: The compound's hydroxyl group is pivotal in facilitating hydrogen bonding, which can significantly enhance its interaction with biological targets, such as enzymes and receptors.
  • Research Potential: Scientists are continually investigating the biological properties of this compound. Studies have indicated that derivatives of N-(4-chlorophenyl)-N-hydroxy-acetamide can exhibit varying levels of antimicrobial activity, making it a candidate for further exploration.
  • Safety and Toxicology: As with many chemical compounds, understanding the safety profile is essential. Preliminary studies often assess the toxicological aspects to ensure safe handling and application, especially for compounds with pharmaceutical implications.

In summary, N-(4-chlorophenyl)-N-hydroxy-acetamide is not just a simple compound; it's a potential cornerstone for advancements in medicinal chemistry, with its rich chemical characteristics opening avenues for research and development in various fields.

Synonyms
N-(4-Chlorophenyl)-N-hydroxyacetamide
N-Hydroxy-4-chloroacetanilide
Acetamide, N-(4-chlorophenyl)-N-hydroxy-
CCRIS 5131
UNII-1E51G4NMS6
NSC 311947
BRN 2096205
1E51G4NMS6
NSC-311947
DTXSID60164516
N-HYDROXY-P-CHLOROACETANILIDE
N-HYDROXY-4'-CHLOROACETANILIDE
N-HYDROXY-N-P-CHLOROPHENYLACETAMIDE
N-HYDROXY-N-(4-CHLOROPHENYL)ACETAMIDE
N-OH-4ClAA
DTXCID7087007
Acetamide, N-(4-chlorophenyl)-N-hydroxy-(9CI)
cdiayjxlimkajj-uhfffaoysa-n
1503-91-9
N-(p-Chlorophenyl)acetohydroxamic acid
ACETOHYDROXAMIC ACID, N-(p-CHLOROPHENYL)-
NSC311947
SCHEMBL17671229
N-(4-chlorophenyl)-N-hydroxy-acetamide
Acetamide,n-(4-chlorophenyl)-n-hydroxy-
DS-009559
Q27252313