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Chlorphenamine

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Identification
Molecular formula
C16H19ClN2
CAS number
132-22-9
IUPAC name
N'-[(4-chlorophenyl)-phenyl-methyl]-N'-methyl-N-propyl-ethane-1,2-diamine
State
State

At room temperature, chlorphenamine is in a solid state and is typically encountered as a crystalline solid in pharmaceutical formulations.

Melting point (Celsius)
130.00
Melting point (Kelvin)
403.15
Boiling point (Celsius)
433.10
Boiling point (Kelvin)
706.25
General information
Molecular weight
274.79g/mol
Molar mass
274.8130g/mol
Density
1.1995g/cm3
Appearence

Chlorphenamine appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of N'-[(4-chlorophenyl)-phenyl-methyl]-N'-methyl-N-propyl-ethane-1,2-diamine

The solubility of N'-[(4-chlorophenyl)-phenyl-methyl]-N'-methyl-N-propyl-ethane-1,2-diamine in various solvents can be quite intriguing due to its complex structure. Solubility is influenced by several factors, and here are the key points to consider:

  • Polarity: The presence of multiple aromatic rings suggests a relatively non-polar character, which may lead to higher solubility in organic solvents.
  • Hydrogen Bonding: The amine groups (-NH2) can engage in hydrogen bonding with polar solvents, potentially increasing solubility in water to some extent.
  • Temperature Effects: As with many organic compounds, solubility can increase with temperature. Therefore, it might dissolve better in warm solvents.
  • Solvent Compatibility: Alcohols or moderately polar solvents may be favorable for its solubility, compared to highly polar solvents like water.

In conclusion, while this compound is likely to be more soluble in non-polar organic solvents, it shows potential for moderate solubility in polar solvents due to its amine functional groups. This dual characteristic makes it a fascinating case for solubility studies.

Interesting facts

Interesting Facts about N'-[(4-chlorophenyl)-phenyl-methyl]-N'-methyl-N-propyl-ethane-1,2-diamine

This compound is a fascinating example of a synthetic amine that has garnered interest in various fields, particularly in medicinal chemistry. Here are some remarkable points about this compound:

  • Structure and Function: The compound features a complex molecular structure with multiple functional groups. Its configuration encompasses a phenyl ring and a chlorobenzene moiety, making it a versatile candidate for studying structure-activity relationships in drug discovery.
  • Potential Biological Activity: Compounds with similar structural traits have been explored for their potential as antidepressants and antipsychotics. This opens avenues for the investigation into how slight changes in molecular design can impact therapeutic efficacy.
  • Synthesis Techniques: The synthetic pathways leading to the creation of this compound involve intricate multi-step reactions. Chemists often exploit various techniques, including amine coupling and reductions, to achieve the desired product, contributing to the broader discourse on synthetic methodologies.
  • Medicinal Chemistry Insights: Studying this compound may provide insights into how alterations in the ethylamine chain and the positioning of substituents influence its biological outcomes. Research in this domain has the potential to unravel new mechanisms of action pertaining to pharmacology.
  • Safety and Handling: As with many chemical compounds, it is vital to understand the safety profiles. The presence of chlorine introduces variables in reactivity and toxicity that need stringent assessment for safe handling in laboratory settings.

Overall, the exploration of N'-[(4-chlorophenyl)-phenyl-methyl]-N'-methyl-N-propyl-ethane-1,2-diamine is an engaging journey through the realms of chemistry and pharmacology, offering potential breakthroughs in the quest for effective pharmaceuticals.