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N-(4-chlorophenyl)formamide

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Identification
Molecular formula
C7H6ClNO
CAS number
29816-17-9
IUPAC name
N-(4-chlorophenyl)formamide
State
State

At room temperature, N-(4-chlorophenyl)formamide is in a solid state.

Melting point (Celsius)
101.00
Melting point (Kelvin)
374.15
Boiling point (Celsius)
324.00
Boiling point (Kelvin)
597.15
General information
Molecular weight
155.57g/mol
Molar mass
155.5690g/mol
Density
1.3280g/cm3
Appearence

N-(4-chlorophenyl)formamide is a white to off-white solid. It typically appears as a crystalline compound under standard conditions.

Comment on solubility

Solubility of N-(4-chlorophenyl)formamide

N-(4-chlorophenyl)formamide, with its unique structure, presents an intriguing profile when it comes to solubility. Generally, the solubility of this compound can be influenced by several factors:

  • Polarity: The presence of the 4-chlorophenyl group contributes to the compound's overall polarity, affecting its ability to dissolve in various solvents.
  • Solvent Type: N-(4-chlorophenyl)formamide tends to exhibit higher solubility in polar solvents such as water and alcohols compared to non-polar solvents. This is primarily due to the compound's polar functional groups.
  • Temperature Dependency: Solubility is often enhanced at elevated temperatures. Thus, heating the solvent may increase the solubility of N-(4-chlorophenyl)formamide, facilitating better dissolution.
  • Hydrogen Bonding: The presence of the amide functional group allows for potential hydrogen bonding with water molecules, further enhancing its solubility in polar environments.

In summary, while N-(4-chlorophenyl)formamide is expected to be soluble in polar solvents, the extent of this solubility can vary widely based on various conditions, including the solvent used and ambient temperature. The interplay of these factors makes solubility a fascinating aspect of studying this compound.

Interesting facts

Interesting Facts about N-(4-chlorophenyl)formamide

N-(4-chlorophenyl)formamide, often encountered in organic synthesis, is a fascinating compound with a variety of applications and intriguing properties. Here are some interesting highlights:

  • Chemistry and Structure: This compound possesses an amide functional group, which plays a crucial role in its reactivity. The presence of the 4-chlorophenyl group enhances its polarity and can influence its interaction with biological systems.
  • Uses in Synthesis: N-(4-chlorophenyl)formamide is commonly utilized as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its significance in the development of new drugs cannot be overstated, as it contributes to the molecular diversity that is essential for medicinal chemistry.
  • Biological Activity: Compounds similar to N-(4-chlorophenyl)formamide have been studied for their biological activities. Research indicates that derivatives of this compound might exhibit anti-cancer and anti-inflammatory properties, making it a potential candidate for further exploration in drug discovery.
  • Environmental Impact: As with many chemical compounds, understanding the impact of N-(4-chlorophenyl)formamide on the environment is critical. Its behavior in ecological systems has been a subject of investigation, especially regarding its potential toxicity and degradation pathways.
  • Research and Development: Ongoing studies are focusing on the optimization of synthesis routes for N-(4-chlorophenyl)formamide to improve yield and reduce costs. *“Innovation in synthetic methods is key to advancing the field of organic chemistry,”* says many researchers.

In conclusion, N-(4-chlorophenyl)formamide is not just another chemical compound; it represents a bridge between fundamental chemistry and practical applications in pharmaceuticals and environmental science. The continuous exploration of its properties and potential uses will likely yield more insights in the years to come.

Synonyms
N-(4-Chlorophenyl)formamide
2617-79-0
4-Chloroformanilide
P-CHLOROFORMANILIDE
4'-Chloroformanilide
N-(p-Chlorophenyl)formamide
Formic acid p-chlorophenylamide
Formanilide, 4'-chloro-
NSC 26266
p-Chlorfenylamid kyseliny mravenci
BRN 2206008
AI3-18913
p-Chlorfenylamid kyseliny mravenci [Czech]
DTXSID00180795
4-12-00-01177 (Beilstein Handbook Reference)
DTXCID40103286
621-724-9
Formamide, N-(4-chlorophenyl)-
4-Chlorophenylformamide
p-ClC6H4NHCHO
N-(4-Chloro-phenyl)-formamide
MFCD00021020
N-Formyl-p-chloroaniline
1-Chloro-4-formamidobenzene
SCHEMBL183037
CHEMBL3252143
NSC26266
NSC-26266
AKOS012525266
AS-37217
C1945
CS-0172740
AR-360/41301998