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4-Ethoxyphenyl trifluoroacetamide

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Identification
Molecular formula
C10H10F3NO2
CAS number
1735-23-1
IUPAC name
N-(4-ethoxyphenyl)-2,2,2-trifluoro-acetamide
State
State

4-Ethoxyphenyl trifluoroacetamide is typically found in a solid state at room temperature. It exhibits stability and is generally non-volatile under standard laboratory conditions.

Melting point (Celsius)
102.00
Melting point (Kelvin)
375.15
Boiling point (Celsius)
271.00
Boiling point (Kelvin)
544.15
General information
Molecular weight
233.21g/mol
Molar mass
233.2060g/mol
Density
1.2510g/cm3
Appearence

4-Ethoxyphenyl trifluoroacetamide appears as a white crystalline solid. It can typically be found in a powdered form when not in solution. The crystalline nature can sometimes cause it to appear shiny under light.

Comment on solubility

Solubility of N-(4-ethoxyphenyl)-2,2,2-trifluoro-acetamide

N-(4-ethoxyphenyl)-2,2,2-trifluoro-acetamide exhibits a unique solubility profile that is important for its applications in various chemical contexts. The presence of the trifluoro group may enhance the polarity of the molecule, influencing its interaction with solvents.

  • Solvent Interaction: The compound tends to be more soluble in polar solvents such as dimethyl sulfoxide (DMSO) and methanol.
  • Insoluble in Water: However, it is generally insoluble in water due to the hydrophobic characteristics of the ethoxyphenyl moiety.
  • Performance in Organic Solvents: It shows effective solubility in organic solvents, which is advantageous for its application in organic synthesis.

When discussing solubility, it is often said, "Like dissolves like," emphasizing that polar compounds will dissolve well in polar solvents while nonpolar compounds favor nonpolar solvents. Understanding this concept can be crucial when selecting appropriate solvents for experiments involving N-(4-ethoxyphenyl)-2,2,2-trifluoro-acetamide.

In conclusion, the solubility of this compound is dictated by its molecular structure and the surrounding environment, making it essential to consider these aspects during practical applications.

Interesting facts

Interesting Facts about N-(4-ethoxyphenyl)-2,2,2-trifluoro-acetamide

N-(4-ethoxyphenyl)-2,2,2-trifluoro-acetamide, often referred to as a highly versatile compound, has intriguing applications and characteristics that make it a subject of interest in both organic chemistry and pharmaceuticals. Below are some engaging facts about this unique compound:

  • Chemical Structure: This compound features a trifluoroacetamide moiety, which contributes significantly to its reactivity. The presence of multiple fluorine atoms in the structure often enhances stability and affects various properties such as lipophilicity.
  • Biological Activity: Compounds containing amide functional groups, like N-(4-ethoxyphenyl)-2,2,2-trifluoro-acetamide, are known for their biological significance. They often exhibit a range of pharmacological properties, making them candidates for drug development.
  • Application in Drug Design: Molecules with fluorinated components can lead to compounds with improved metabolic stability. Their unique electronic properties can be pivotal in drug design, allowing for the fine-tuning of interactions with biological targets.
  • Use in Synthetic Chemistry: This compound can be utilized as an important intermediate in the synthesis of other complex organic molecules, showcasing its versatility in synthetic organic chemistry.
  • Sustainability Aspects: The incorporation of fluorine in compounds is often researched due to its potential in creating more efficient and environmentally friendly products through improved efficacy and reduced quantities needed.

In summary, N-(4-ethoxyphenyl)-2,2,2-trifluoro-acetamide represents a fascinating area of study within organic chemistry, linking the fields of synthesis and biological activity. As chemists continue to explore its properties and applications, we can anticipate advancements in both material science and medicinal chemistry.

Synonyms
N-(4-ethoxyphenyl)-2,2,2-trifluoroacetamide
457-53-4
Acetamide, N-(4-ethoxyphenyl)-2,2,2-trifluoro-
BRN 2976383
2,2,2-Trifluoro-p-acetophenetidide
p-ACETOPHENETIDIDE, 2,2,2-TRIFLUORO-
N-trifluoroacetyl-p-phenetidine
DTXSID20963426
SPQLXRCPBSSJCE-UHFFFAOYSA-N
STK412309
AKOS000511628
4-13-00-01093 (Beilstein Handbook Reference)
AcetaMide, 2,2,2-trifluoro-N-(4-ethoxyphenyl)-