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Phenacetin

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Identification
Molecular formula
C10H13NO2
CAS number
62-44-2
IUPAC name
N-(4-ethoxyphenyl)-N-methyl-acetamide
State
State
At room temperature, Phenacetin is a solid and is often found in the form of powder or crystals.
Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
375.00
Boiling point (Kelvin)
648.15
General information
Molecular weight
179.22g/mol
Molar mass
179.2150g/mol
Density
1.0994g/cm3
Appearence
Phenacetin appears as a white, crystalline solid with a shiny or pearly luster. It is odorless and tasteless, which makes it ideal for pharmaceutical formulations.
Comment on solubility

Solubility of N-(4-ethoxyphenyl)-N-methyl-acetamide

N-(4-ethoxyphenyl)-N-methyl-acetamide, known for its intriguing chemical behavior, exhibits varying solubility characteristics that are influenced by several factors. Understanding its solubility can be quite fascinating, as it's not a straightforward aspect. Here are some critical points to consider:

  • Polarity: This compound contains both hydrophobic (the ethoxy and phenyl groups) and hydrophilic (the amide group) components. As a result, it often demonstrates moderate solubility in polar solvents such as water and alcohols, while being more soluble in non-polar solvents like hexane.
  • Solvent Interaction: The solubility often depends on the solvent used. In polar solvents, hydrogen bonding with the amide group enhances solubility, while in non-polar solvents, the hydrophobic regions respond favorably to similar environments.
  • Temperature Effect: Increased temperature typically leads to enhanced solubility for most compounds, including N-(4-ethoxyphenyl)-N-methyl-acetamide. Warm solutions can dissolve higher concentrations due to increased kinetic energy.
  • pH Influence: The solubility may also vary with changes in pH, particularly for compounds containing amide groups due to potential protonation or deprotonation in different pH environments.

Overall, the solubility of N-(4-ethoxyphenyl)-N-methyl-acetamide can be described as selective, showing a propensity for polar and moderately polar solvents. Understanding these characteristics aids in application and handling in various chemical environments.

Interesting facts

Interesting Facts about N-(4-ethoxyphenyl)-N-methyl-acetamide

N-(4-ethoxyphenyl)-N-methyl-acetamide is a fascinating compound that belongs to the class of amides, which are characterized by the presence of a carbonyl group linked to a nitrogen atom. This compound has several attributes worth noting:

  • Role in Pharmaceuticals: N-(4-ethoxyphenyl)-N-methyl-acetamide is often studied for its potential applications in medicinal chemistry. Its structural features may contribute to a broad spectrum of biological activity, making it a candidate for drug development and pharmacological research.
  • Structure-Activity Relationship: The unique arrangement of its ethoxy and methyl groups can significantly influence its interaction with biological targets. Understanding these relationships is crucial for optimizing efficacy and reducing potential side effects in pharmaceutical applications.
  • Synthetic Versatility: This compound can be synthesized through various methods, showcasing the versatility of organic synthesis techniques. These methods often serve as a practical exploration of reaction mechanisms and the principles of organic chemistry.
  • Integration in Chemical Education: N-(4-ethoxyphenyl)-N-methyl-acetamide serves as a great example in teaching students about functional groups, reactivity patterns, and the significance of molecular architecture in determining compound properties.

In the words of noted chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This compound exemplifies the diverse pathways and potentials that emerge when exploring the world of organic chemistry.

Overall, N-(4-ethoxyphenyl)-N-methyl-acetamide illustrates not only the complexity of chemical structures but also their relevance to real-world applications, particularly in the ongoing quest for new therapeutic agents.

Synonyms
N-Methylphenacetin
Methylphenacetin
N-(4-Ethoxyphenyl)-N-methylacetamide
BRN 2721491
Acetamide, N-(4-ethoxyphenyl)-N-methyl-
p-ACETOPHENETIDIDE, N-METHYL-
Phenacetin methyl derivative
DTXSID60223258
0-13-00-00466 (Beilstein Handbook Reference)
DTXCID60145749
llykxhaeyfjrqz-uhfffaoysa-n
7298-73-9
4'-ethoxy-N-methylacetanilide
SCHEMBL3832407
N-(4-Ethoxyphenyl)-N-methylacetamide #
NS00011453