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N-(4-fluorobutyl)acetamide

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Identification
Molecular formula
C6H12FNO
CAS number
627035-61-8
IUPAC name
N-(4-fluorobutyl)acetamide
State
State

At room temperature, N-(4-fluorobutyl)acetamide is predominantly a liquid. Its state can be influenced by the specific environmental conditions it is subjected to, including temperature and pressure adjustments.

Melting point (Celsius)
-55.00
Melting point (Kelvin)
218.15
Boiling point (Celsius)
235.00
Boiling point (Kelvin)
508.15
General information
Molecular weight
147.18g/mol
Molar mass
147.1750g/mol
Density
1.0530g/cm3
Appearence

N-(4-fluorobutyl)acetamide is typically a colorless to light yellow liquid. It might appear as a clear fluid with viscosity similar to other amides derived from primary amines. The appearance can vary depending on purity and handling conditions.

Comment on solubility

Solubility of N-(4-fluorobutyl)acetamide

N-(4-fluorobutyl)acetamide, with the chemical formula C6H12FNO, exhibits unique solubility characteristics that are influenced by its molecular structure. Understanding the solubility behavior of this compound is essential for applications in various chemical contexts.

Key Solubility Insights:

  • Polarity: The presence of the polar acetamide functional group enhances solubility in polar solvents, such as water.
  • Alkyl Chain Influence: The hydrophobic nature of the butyl group may reduce overall solubility in highly polar solvents.
  • Fluorine Effect: The fluorine atom increases electronegativity, potentially contributing to intermolecular interactions with water molecules.

In general, N-(4-fluorobutyl)acetamide is expected to be:

  • Soluble in polar organic solvents such as dimethyl sulfoxide (DMSO) and ethanol.
  • Less soluble in nonpolar solvents, which aligns with the behavior typically observed in amides.

This compound's solubility profile can be summarized as a balance between its polar acetamide group and the nonpolar characteristics introduced by the butyl group. Therefore, applications that leverage its solubility should carefully consider the solvent environment to optimize interactions.

Interesting facts

Interesting Facts about N-(4-fluorobutyl)acetamide

N-(4-fluorobutyl)acetamide is a fascinating compound that showcases various intriguing aspects of chemistry. As a derivative of acetamide, it contains both nitrogen and fluorine, which play pivotal roles in its chemical behavior.

Key Highlights:

  • Fluorine Substitution: The introduction of fluorine into organic compounds can drastically change their physical and chemical properties. In this case, the fluorine atom contributes to the compound's unique reactivity and potential applications.
  • Amide Bond: The presence of the amide functional group (–CONH2) is significant in biological systems. Amides are known for their stability and play a critical role in protein structure and function.
  • Potential Applications: Due to its specific structural features, N-(4-fluorobutyl)acetamide may be explored for use in pharmaceuticals, agrochemicals, and other specialized chemical applications.
  • Investigative Interest: Compounds like N-(4-fluorobutyl)acetamide are often subjects of study in medicinal chemistry, especially for their potential biological activities. Researchers may investigate the compound for neuroactive and analgesic properties.

As with many fluorinated compounds, understanding N-(4-fluorobutyl)acetamide involves exploring its electronic structure, interactions with biological systems, and its broader environmental impact. The study of such compounds not only adds depth to our knowledge of chemistry but also sparks innovative ideas in drug design and materials science.

In the words of a famous chemist, "Chemistry is the science of opportunity," and compounds like N-(4-fluorobutyl)acetamide highlight the boundless possibilities that chemical research offers for future discoveries and applications.

Synonyms
N-4-Fluorobutylacetamide
ACETAMIDE, N-(4-FLUOROBUTYL)-
373-08-0
BRN 1749680
DTXSID30190741
4-04-00-00610 (Beilstein Handbook Reference)
DTXCID70113232
AKOS006354338