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Capsaicin

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Identification
Molecular formula
C18H27NO3
CAS number
404-86-4
IUPAC name
N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide
State
State

At room temperature, capsaicin is typically in a crystalline or sporadically waxy solid form.

Melting point (Celsius)
62.00
Melting point (Kelvin)
335.15
Boiling point (Celsius)
210.00
Boiling point (Kelvin)
483.15
General information
Molecular weight
305.41g/mol
Molar mass
305.4070g/mol
Density
1.1200g/cm3
Appearence

Capsaicin is a hydrophobic, colorless, crystalline or waxy compound. It is the active component in chili peppers.

Comment on solubility

Solubility of N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide

N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide, with the chemical formula C18H27NO3, is a compound that exhibits interesting solubility characteristics which are essential for its applications. Understanding its solubility can help predict its behavior in various environments.

Factors Influencing Solubility

The solubility of this compound can be affected by several factors:

  • Polarity: The presence of both hydrophilic (such as the hydroxyl group) and lipophilic (the long carbon chain) parts can lead to variable solubility in polar and non-polar solvents.
  • Temperature: Generally, increasing the temperature can enhance solubility, particularly in organic solvents.
  • pH Levels: The compound may exhibit changes in solubility under different pH conditions due to ionization of functional groups.

General Solubility Outlook

Considering its structure, one might anticipate that:

  • In **polar solvents** (like water), solubility may be limited due to the hydrophobic nature of the nonanamide chain.
  • In **organic solvents** (such as ethanol or DMSO), the compound is expected to show better solubility due to its non-polar characteristics.
  • The presence of methoxy and hydroxyl groups can provide some degree of interaction with polar solvents, potentially enhancing solubility to a degree.

In conclusion, while N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide displays complex solubility behavior, its solubility largely depends on the solvent type and environmental conditions. Understanding these aspects can facilitate better utilization in chemical formulations and applications.

Interesting facts

Interesting Facts about N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide

N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide, often regarded for its complex structure and intriguing properties, is a compound that embodies the intersection of organic chemistry and medicinal research. Here are some notable facts:

  • Structural Complexity: This compound contains both an aromatic ring and a long hydrocarbon chain, which contributes to its diverse chemical and physical properties.
  • Potential Biological Activity: Many phenolic compounds, including derivatives like this one, have been studied for their potential antioxidant and anti-inflammatory properties, making them interesting subjects in pharmacology.
  • Applications in Research: Compounds with a similar structure may be researched for their ability to interact with biological systems, influencing pathways and potentially leading to new therapeutic agents.
  • Synthesis Challenges: The synthesis of compounds like N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide often involves multiple steps requiring careful control of reaction conditions, making it a rewarding project for chemistry students.
  • Current Trends: As the search for more effective and less toxic pharmaceuticals continues, compounds like this will likely attract attention for their unique functionalities.

As a chemical scientist or student, studying this compound opens doors to numerous discussions regarding molecular interactions and their implications in drug development. Keep an eye on developments in this area, as the integration of such compounds in therapeutic applications could lead to significant advancements in health sciences.

Synonyms
NONIVAMIDE
2444-46-4
N-Vanillylnonanamide
Pseudocapsaicin
N-Vanillylnonamide
Pelargonic acid vanillylamide
N-(4-Hydroxy-3-methoxybenzyl)nonanamide
N-Vanillylpelargonamide
Nonanoic acid vanillylamide
N-Nonanoyl vanillylamide
Vanillyl pelargonic amide
Pelargonyl vanillylamide
Hydroxymethoxybenzyl pelargonamide
Vanillyl-N-nonylamide
Nonylic acid vanillylamide
Vanillyl n-nonoylamide
Nonivamida
Nonanamide, N-vanillyl-
Nonanoyl vanillylamide
Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-
FEMA No. 2787
Nonivamide [INN]
Nonivamidum
Nonylvanylamide
Hansaplast
desmethyldihydrocapsaicin
NSC 172795
Nonanoyl 4-hydroxy-3-methoxybenzylamide
N-Vanillylnonanoamide
N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide
PAVA
Vanillyl n-Nonylamide
Nonylic acid vanillyamide
Nonivamidum [INN-Latin]
vanillylnonanamide
Nonivamida [INN-Spanish]
EINECS 219-484-1
NSC-172795
UNII-S846B891OR
BRN 2144300
N-vanillyl nonanamide
CHEBI:46936
S846B891OR
AH-23491X
N-((4-Hydroxy-3-methoxyphenyl)methyl)nonanamide
N-((Hydroxy-3-methoxyphenyl)methyl)4-nonanamide
CHEMBL75124
DTXSID1034769
Nonivamide (INN)
Nonanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-
NCGC00016089-05
Nonivamidum (INN-Latin)
Nonivamida (INN-Spanish)
NONIVAMIDE (MART.)
NONIVAMIDE [MART.]
DTXCID9014769
vanillylnonamide
Capsaicin synthetic
CAS-2444-46-4
8-Nordihydrocapsaicin
N-vanillyl-nonanamide
Nonanoylvanillyl Amide
Capsaicin (Synthetic)
N-((4-Hydroxy-3-methoxyphenyl)methyl)-Nonanamide
N-[(4-Hydroxy-3-methoxyphenyl)methyl]-Nonanamide
N-Nonylvanylamide
Nonivamide; Pseudocapsaicin; PAVA; Pelargonic acid vallinylamide; Vanillyl N-nonylamide
PAVA spray
Hansaplast (TN)
Nonylic vanillamide
Synthetic capsaicin
Nonoyl vanillylamide
MFCD00017286
PSVA
Nonivamide (Standard)
Spectrum_000311
Pelargonoyl vanillylamide
SpecPlus_000799
N-Pelargonylvanillylamide
Spectrum2_001091
Spectrum4_000916
Spectrum5_001853
Lopac-V-9130
N-Vanillylnonanamide, 8CI
NONIVAMIDE [WHO-DD]
Lopac0_001218
SCHEMBL81939
KBioGR_001412
KBioSS_000791
MLS002153373
DivK1c_006895
SPECTRUM2300192
SPBio_001162
N-Pelargonic Acid Vanillylamide
FEMA 2787
KBio1_001839
KBio2_000791
KBio2_003359
KBio2_005927
HH 50
HMS2234E23
HMS3374K02
HMS3885C14
Pharmakon1600-01506172
ALBB-025790
Tox21_110302
Tox21_301218
BDBM50044767
CCG-39764
HY-17568R
NSC172795
NSC760391
s3935
AKOS001719931
N-Vanillylnonanamide, >=97%, powder
Tox21_110302_1
AC-4807
DB11324
FC71174
NSC-760391
N-Vanillylnonanamide, analytical standard
NCGC00016089-01
NCGC00016089-02
NCGC00016089-03
NCGC00016089-04
NCGC00016089-06
NCGC00094463-01
NCGC00094463-02
NCGC00094463-03
NCGC00094463-04
NCGC00255553-01
AS-13519
HY-17568
SMR001230764
N-(4-Hydroxy-3-methoxybenzyl)nonanamide #
NONIVAMIDE (CONSTITUENT OF CAPSICUM)
EU-0101218
M0900
Nonanamide, N-(4-hydroxy-3-methoxybenzyl)-
NS00002166
4-Hydroxy-3-methoxy-N-(1-oxononyl)-Benzamide
D08282
V 9130
V-3000
AB00053157_06
EN300-1692889
N-NONANOYL-4-HYDROXY-3-METHOXYBENZYL-AMIDE
NONIVAMIDE (CONSTITUENT OF CAPSICUM) [DSC]
Q420228
SR-01000076196
SR-01000076196-1
BRD-K05907307-001-07-1
N-[(4-Hydroxy-3-methoxyphenyl)methyl]nonanamide, 9CI
Z373586944
N-NONANOYL-4-HYDROXY-3-METHOXYBENZYL-AMIDE [FHFI]
Nonivamide, European Pharmacopoeia (EP) Reference Standard
N-Vanillylnonanamide; N-(4-Hydroxy-3-methoxybenzyl)nonanamide
Pelargonic acid vanillylamide;N-Vanillylpelargonamide;Capsaicin (synthetic)
Capsaicin synth.; N-Vanillylpelargonamide; Nonylvanylamide; Pelargonic acid vanillylamide
219-484-1