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Paracetamol (Acetaminophen)

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Identification
Molecular formula
C8H9NO2
CAS number
103-90-2
IUPAC name
N-(4-hydroxyphenyl)-2-methyl-prop-2-enamide
State
State

At room temperature, Paracetamol is in a solid state. It is usually available in the form of tablets or capsules for medicinal use, and also as powder or crystalline form when not pressed into these forms.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
151.16g/mol
Molar mass
151.1640g/mol
Density
1.2930g/cm3
Appearence

Paracetamol, also known as Acetaminophen, typically appears as a white, odorless crystalline powder. It is commonly pressed into tablets for medicinal use. The pure compound is also tasteless.

Comment on solubility

Solubility of N-(4-hydroxyphenyl)-2-methyl-prop-2-enamide

The solubility of N-(4-hydroxyphenyl)-2-methyl-prop-2-enamide can be influenced by several factors, owing to its unique structure. This organic compound, featuring both an amide group and aromatic hydroxyl functionality, exhibits interesting behavior in different solvents.


Factors Affecting Solubility

  • Polarity: The presence of the hydroxyl group enhances polarity, potentially increasing solubility in polar solvents such as water.
  • Hydrogen Bonding: Ability to engage in hydrogen bonding can increase interactions with solvent molecules, improving solubility.
  • Chain Length: The methyls in the compound can introduce hydrophobic characteristics, potentially impacting solubility in non-polar environments.

In practice, one might observe greater solubility in alcohols and dimethyl sulfoxide (DMSO) compared to alkane solvents, which may limit solubility. Understanding these factors is crucial for practical applications, where solubility can significantly affect the compound's reactivity and performance in various chemical processes.

Interesting facts

Interesting Facts about N-(4-hydroxyphenyl)-2-methyl-prop-2-enamide

N-(4-hydroxyphenyl)-2-methyl-prop-2-enamide, also known as a derivatives of acrylamide, is an intriguing compound due to its diverse applications and potential health implications. Here are some fascinating aspects that make this compound noteworthy:

  • Biological Relevance: This compound contains a phenolic group that is often linked to various biological activities. Research has shown that compounds with hydroxyl groups can exhibit significant antioxidant properties, which may help in combating oxidative stress in living organisms.
  • Industrial Uses: N-(4-hydroxyphenyl)-2-methyl-prop-2-enamide is utilized in the synthesis of polymers and can be incorporated as a monomer in material science, contributing to the development of new materials with enhanced properties.
  • Pharmaceutical Potential: The compound's structure suggests that it may possess advantageous reactions in medicinal chemistry. Investigations into its pharmacological effects may lead to novel therapeutic agents, particularly in the area of anti-cancer drugs due to the presence of the unsaturated amide group.
  • Environmental Considerations: Like many chemical compounds, the environmental persistence and biodegradability of N-(4-hydroxyphenyl)-2-methyl-prop-2-enamide warrant ongoing assessment. Understanding how such compounds behave in ecosystems helps in evaluating their impact.
  • Safety Concerns: Certain acrylamide derivatives have raised safety questions regarding their neurotoxic effects. Thus, studying N-(4-hydroxyphenyl)-2-methyl-prop-2-enamide is vital as it can provide insights into its toxicity profiles and safe usage guidelines.

In summary, N-(4-hydroxyphenyl)-2-methyl-prop-2-enamide is more than just a chemical compound; it embodies a rich tapestry of research potential that spans from industrial applications to essential insights in health and environmental science.

Synonyms
N-(4-Hydroxyphenyl)methacrylamide
2-Propenamide, N-(4-hydroxyphenyl)-2-methyl-
2-Propenamide, N-(4-hydroxyphenyl)-2-methyl-(9CI)
680-099-0
RefChem:478839
19243-95-9
N-(4-hydroxyphenyl)-2-methylprop-2-enamide
MFCD00080530
4'-Hydroxy-2-methylacrylanilide
BRN 1943716
ACRYLANILIDE, 4'-HYDROXY-2-METHYL-
N-(4-Hydroxyphenyl)-2-methyl-2-propenamide
2-Propenamide,N-(4-hydroxyphenyl)-2-methyl-
p-hydroxymethacrylanilide
4-methacryloylaminophenol
4'-hydroxymethacrylanilide
N-(4-hydroxyphenyl)-2-methyl-prop-2-enamide
SCHEMBL124216
N-p-Hydroxyphenyl Methacrylamide
DTXSID40172836
AKOS006344463
(4-Hydroxyphenyl)methacrylamide, >=98%
AS-66205
SY054331
H1164
D91010