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Paracetamol

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Identification
Molecular formula
C8H9NO2
CAS number
103-90-2
IUPAC name
N-(4-hydroxyphenyl)-2-phenyl-butanamide
State
State

At room temperature, paracetamol is in a solid state. The compound typically exists as a white crystalline powder, reflecting its stability and solid structure under standard conditions.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
420.20
Boiling point (Kelvin)
693.35
General information
Molecular weight
151.17g/mol
Molar mass
151.1650g/mol
Density
1.2630g/cm3
Appearence

Paracetamol appears as a colorless to white crystalline solid. It is almost odorless and has a slightly bitter taste. The substance is often found in powder or crystalline form, with crystals mainly appearing needle-like or in the form of scales.

Comment on solubility

Solubility of N-(4-hydroxyphenyl)-2-phenyl-butanamide

N-(4-hydroxyphenyl)-2-phenyl-butanamide presents interesting solubility characteristics due to its unique molecular structure. Understanding its solubility is crucial for applications in pharmaceuticals and other fields. Here are some key points regarding its solubility:

  • Solvent Polarity: This compound is likely to be more soluble in polar solvents due to the presence of the hydroxyl group, which can engage in hydrogen bonding.
  • Hydrogen Bonding: The hydroxyl (-OH) group can significantly enhance solubility in water, as it allows for intermolecular interactions between the compound and water molecules.
  • Aromatic Interactions: The presence of phenyl groups may result in lower solubility in nonpolar solvents due to the compound's tendency to engage in π-π stacking interactions.
  • Temperature Effects: Solubility can also be affected by temperature, with higher temperatures potentially increasing solubility through enhanced molecular motion.
  • pH Dependence: The solubility may change with pH levels, particularly in aqueous solutions, which can alter the ionization state of the compound.

In conclusion, while N-(4-hydroxyphenyl)-2-phenyl-butanamide exhibits varying solubility based on the solvent and environmental conditions, its ability to engage in hydrogen bonding and aromatic interactions plays a pivotal role in determining its solubility profile.

Interesting facts

Interesting Facts about N-(4-hydroxyphenyl)-2-phenyl-butanamide

N-(4-hydroxyphenyl)-2-phenyl-butanamide, often referred to in scientific literature for its unique structure, offers a wealth of intriguing features worth exploring:

  • Pharmacological Potential: This compound has garnered attention for its potential pharmaceutical applications. Research indicates that it may exhibit properties beneficial in anti-inflammatory and analgesic therapies, making it a candidate for further study in drug development.
  • Structural Significance: The structural characteristics of N-(4-hydroxyphenyl)-2-phenyl-butanamide include a hydroxyphenyl group that contributes to its interaction within biological systems, influencing solubility and bioactivity.
  • Applications in Organic Synthesis: As a building block in organic chemistry, this compound can be utilized in various synthesis reactions, highlighting its versatility and importance in creating more complex organic molecules.
  • Chemical Stability: Its stability under a range of conditions makes it an interesting subject for studies focused on the reactivity of amides, providing insights into amide bond behavior in biological and synthetic pathways.
  • Interdisciplinary Connections: The study of this compound connects various fields such as >pharmaceutical chemistry, organic chemistry, and materials science, demonstrating the interconnectedness of chemical research.

Overall, N-(4-hydroxyphenyl)-2-phenyl-butanamide exemplifies how a single compound can be a gateway to exploring broader scientific principles and potential applications. With ongoing research, we may uncover even more exciting aspects of this compound and its role in modern science.

Synonyms
N-(4-hydroxyphenyl)-2-phenylbutanamide
2769-41-7
4'-Hydroxy-2-phenylbutyranilide
BRN 2135208
BUTYRANILIDE, 4'-HYDROXY-2-PHENYL-
p-(N-(alpha-Phenylbutyroyl))aminophenol [French]
p-(N-(alpha-Phenylbutyroyl))aminophenol
4-13-00-01124 (Beilstein Handbook Reference)
DTXSID00950354
AKOS005874542
AN-652/41817625