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N-(4-iodophenyl)acetamide

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Identification
Molecular formula
C8H8INO
CAS number
67682-45-7
IUPAC name
N-(4-iodophenyl)acetamide
State
State
The compound is typically found in a solid state at room temperature, often crystallizing in a white powder form. It is stable under standard conditions but should be stored in a cool, dry place to prevent degradation.
Melting point (Celsius)
196.00
Melting point (Kelvin)
469.15
Boiling point (Celsius)
355.00
Boiling point (Kelvin)
628.15
General information
Molecular weight
247.05g/mol
Molar mass
247.0530g/mol
Density
2.0382g/cm3
Appearence

N-(4-iodophenyl)acetamide appears as a white to off-white crystalline solid. Its solid nature at room temperature often results in a fine powder form, which can clump together into larger granules or remain as smaller particles depending on handling and storage conditions.

Comment on solubility

Solubility of N-(4-iodophenyl)acetamide

N-(4-iodophenyl)acetamide, with the chemical formula C9H10INO, presents interesting characteristics in terms of its solubility. This compound is a derivative of acetamide featuring an iodine substituent, which influences its interactions with solvents.

When discussing the solubility of N-(4-iodophenyl)acetamide, consider the following points:

  • Polarity: The presence of the iodine atom contributes to the compound's overall polarity, which can impact its solubility in various solvents.
  • Solvent Compatibility: This compound is likely to be soluble in polar organic solvents such as methanol and dimethyl sulfoxide (DMSO), while exhibiting limited solubility in nonpolar solvents like hexane.
  • Temperature Influence: Solubility may increase with temperature, making it essential to consider thermal effects during dissolution.
  • Hydrogen Bonding: The amide functional group can engage in hydrogen bonding, which may enhance solubility in polar solvents.

In conclusion, while N-(4-iodophenyl)acetamide has specific solubility traits related to its structure, empirical testing is the best way to determine its solubility in various solvents. As always, addressing solubility is crucial for applications in synthesis and formulation.

Interesting facts

Interesting Facts About N-(4-Iodophenyl)acetamide

N-(4-iodophenyl)acetamide is a fascinating compound that plays a significant role in both academic research and practical applications, especially in the fields of medicinal chemistry and organic synthesis. Here are some key points to consider:

  • Structure and Functional Groups: This compound features an acetamide functional group, which is a derivative of acetic acid. The presence of the iodine atom on the phenyl ring significantly alters its chemical reactivity and biological activity.
  • Biological Activity: Compounds like N-(4-iodophenyl)acetamide are often explored for their potential pharmaceutical properties. They can exhibit various biological activities, including anti-inflammatory and antimicrobial effects, which makes them of interest in drug development.
  • Importance in Organic Synthesis: N-(4-iodophenyl)acetamide can be utilized as an intermediate in the synthesis of other complex molecules. The iodine substituent serves as a site for nucleophilic substitution reactions, enabling further chemical transformations.
  • Applications in Material Science: Beyond its medicinal properties, this compound may also find utility in material science, particularly in the development of new materials with specific electronic or optical properties.
  • Research Potential: Ongoing research into compounds with similar structures often reveals new insights into reaction mechanisms and molecular interactions, which can lead to the discovery of novel therapeutic agents.

In summary, N-(4-iodophenyl)acetamide serves as a prime example of how modifications to simple organic structures can yield diverse and impactful chemical properties. As the field of chemistry continues to evolve, the importance of such compounds in both research and industry cannot be understated.

Synonyms
N-(4-Iodophenyl)acetamide
622-50-4
4-Iodoacetanilide
4'-Iodoacetanilide
p-Iodoacetanilide
Acetamide, N-(4-iodophenyl)-
ACETANILIDE, 4'-IODO-
NSC 2161
BRN 2085726
AI3-23888
DTXSID7060752
4-12-00-01546 (Beilstein Handbook Reference)
para-iodoacetanilide
DTXCID5043267
612-973-4
MFCD00016352
4'-Iodo-acetanilide
Maybridge1_006480
para-acetamino-iodo-benzene
WLN: IR DMV1
N-(4-iodophenyl) acetamide
N-(4-iodophenyl)-acetamide
4-(N-acetylamino)iodobenzene
N-(4-iodo-phenyl)-acetamide
SCHEMBL669782
HMS559O12
Acetamide, N-(4-iodophenyl-)-
NSC2161
NSC-2161
CCG-56184
AKOS002813447
CS-W004143
FI70546
AC-22934
SY051203
I0846
NS00034979
10.14272/SIULLDWIXYYVCU-UHFFFAOYSA-N
EN300-384681
F21272
1Y-0922
AH-034/05420003
doi:10.14272/SIULLDWIXYYVCU-UHFFFAOYSA-N
SR-01000645158-1
Z30316374